Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

[1]  Jérôme Devaux,et al.  Reducing canonical Wingless/Wnt signaling pathway confers protection against mutant Huntingtin toxicity in Drosophila , 2012, Neurobiology of Disease.

[2]  Min Chen,et al.  Comparing Statistical Methods for Constructing Large Scale Gene Networks , 2012, PloS one.

[3]  L. Raymond,et al.  Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function , 2011, Neuroscience.

[4]  R. Morimoto,et al.  A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network , 2011, PLoS genetics.

[5]  Elizabeth M. Tomkinson,et al.  The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS. , 2011, Human molecular genetics.

[6]  D. Geschwind,et al.  Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways , 2011, Science Signaling.

[7]  C. Ross,et al.  Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation , 2011, Molecular biology of the cell.

[8]  S. Horvath,et al.  Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology , 2011, Nature.

[9]  A. Barabasi,et al.  Interactome Networks and Human Disease , 2011, Cell.

[10]  C. J. Schmidt,et al.  Chronic Suppression of Phosphodiesterase 10A Alters Striatal Expression of Genes Responsible for Neurotransmitter Synthesis, Neurotransmission, and Signaling Pathways Implicated in Huntington's Disease , 2011, Journal of Pharmacology and Experimental Therapeutics.

[11]  S. Humbert,et al.  Mutant huntingtin‐impaired degradation of β‐catenin causes neurotoxicity in Huntington's disease , 2010, The EMBO journal.

[12]  R. E. Hughes,et al.  Neurobiology of Huntington's Disease : Applications to Drug Discovery , 2010 .

[13]  Christian Neri,et al.  SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis , 2010, Proceedings of the National Academy of Sciences.

[14]  N. Perrimon,et al.  A Genomewide RNA Interference Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila , 2010, Genetics.

[15]  M. Diamond,et al.  F-Actin Binding Regions on the Androgen Receptor and Huntingtin Increase Aggregation and Alter Aggregate Characteristics , 2010, PloS one.

[16]  P. Cullen,et al.  The retromer complex. , 2010, Advances in enzyme regulation.

[17]  S. Finkbeiner,et al.  IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome , 2009, The Journal of cell biology.

[18]  S. Finkbeiner,et al.  Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice , 2009, Neuron.

[19]  Daniel H. Geschwind,et al.  Neuroscience in the era of functional genomics and systems biology , 2009, Nature.

[20]  Judith Frydman,et al.  The Chaperonin TRIC Blocks a Huntingtin Sequence Element that promotes the Conformational Switch to Aggregation , 2009, Nature Structural &Molecular Biology.

[21]  Jing Fan,et al.  Interaction of Postsynaptic Density Protein-95 with NMDA Receptors Influences Excitotoxicity in the Yeast Artificial Chromosome Mouse Model of Huntington's Disease , 2009, The Journal of Neuroscience.

[22]  M. MacDonald,et al.  Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models , 2009, Neurobiology of Disease.

[23]  John R. Yates,et al.  Shotgun Proteomics in Neuroscience , 2009, Neuron.

[24]  S. Grant,et al.  Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins , 2009, Molecular systems biology.

[25]  B. Chait,et al.  Proteomic Studies of a Single CNS Synapse Type: The Parallel Fiber/Purkinje Cell Synapse , 2009, PLoS biology.

[26]  J. Caviston,et al.  Huntingtin as an essential integrator of intracellular vesicular trafficking. , 2009, Trends in cell biology.

[27]  Y. Chernoff,et al.  Abnormal proteins can form aggresome in yeast: aggresome‐targeting signals and components of the machinery , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  Brad T. Sherman,et al.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.

[29]  D. Morrison,et al.  The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. , 2009, Trends in cell biology.

[30]  Steve Horvath,et al.  WGCNA: an R package for weighted correlation network analysis , 2008, BMC Bioinformatics.

[31]  Leslie Michels Thompson,et al.  Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. , 2008, Human molecular genetics.

[32]  Enrique M. Toledo,et al.  Wnt signaling in neuroprotection and stem cell differentiation , 2008, Progress in Neurobiology.

[33]  S. Horvath,et al.  Functional organization of the transcriptome in human brain , 2008, Nature Neuroscience.

[34]  Jun Dong,et al.  Geometric Interpretation of Gene Coexpression Network Analysis , 2008, PLoS Comput. Biol..

[35]  M. Mann,et al.  SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function , 2008, Cell.

[36]  Carlos Cepeda,et al.  Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice , 2008, The Journal of Neuroscience.

[37]  C. Ross,et al.  Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease , 2008, Neurobiology of Disease.

[38]  W. Welch,et al.  ROCK and PRK‐2 mediate the inhibitory effect of Y‐27632 on polyglutamine aggregation , 2008, FEBS letters.

[39]  Janghoo Lim,et al.  Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1 , 2008, Nature.

[40]  Bin Zhang,et al.  Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R , 2008, Bioinform..

[41]  Richard I. Morimoto,et al.  Adapting Proteostasis for Disease Intervention , 2008, Science.

[42]  D. Geschwind,et al.  A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging , 2008, The Journal of Neuroscience.

[43]  K. Kaneko,et al.  14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein , 2008, Neuroscience Letters.

[44]  P. Verstreken,et al.  Suppression of Neurodegeneration and Increased Neurotransmission Caused by Expanded Full-Length Huntingtin Accumulating in the Cytoplasm , 2008, Neuron.

[45]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[46]  Patrik Brundin,et al.  Loss of SNAP‐25 and rabphilin 3a in sensory‐motor cortex in Huntington’s disease , 2007, Journal of neurochemistry.

[47]  S. Humbert,et al.  Phosphorylation of Huntingtin by Cyclin-Dependent Kinase 5 Is Induced by DNA Damage and Regulates Wild-Type and Mutant Huntingtin Toxicity in Neurons , 2007, The Journal of Neuroscience.

[48]  H. Zoghbi,et al.  Trinucleotide repeat disorders. , 2007, Annual review of neuroscience.

[49]  E. Wanker,et al.  Small Molecule Inducers of Heat-Shock Response Reduce polyQ-Mediated Huntingtin Aggregation , 2007, Neurodegenerative Diseases.

[50]  J. Olson,et al.  Huntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration , 2007, PLoS genetics.

[51]  Andy M. Yip,et al.  Gene network interconnectedness and the generalized topological overlap measure , 2007, BMC Bioinformatics.

[52]  Shihua Li,et al.  Multiple pathways contribute to the pathogenesis of Huntington disease , 2006, Molecular Neurodegeneration.

[53]  J. Frydman,et al.  The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions , 2006, Nature Cell Biology.

[54]  A. Barabasi,et al.  A Protein–Protein Interaction Network for Human Inherited Ataxias and Disorders of Purkinje Cell Degeneration , 2006, Cell.

[55]  M. F. Beal,et al.  Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2′dG , 2006, Neurology.

[56]  B. Harper Huntington Disease , 2005, Journal of the Royal Society of Medicine.

[57]  G. Sobue,et al.  17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration , 2005, Nature Medicine.

[58]  S. Horvath,et al.  Statistical Applications in Genetics and Molecular Biology , 2011 .

[59]  Steve D. M. Brown,et al.  Dynein mutations impair autophagic clearance of aggregate-prone proteins , 2005, Nature Genetics.

[60]  Y. Chernoff,et al.  Modulation of Prion-dependent Polyglutamine Aggregation and Toxicity by Chaperone Proteins in the Yeast Model* , 2005, Journal of Biological Chemistry.

[61]  H. Lehrach,et al.  A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. , 2004, Molecular cell.

[62]  Fabrice P Cordelières,et al.  Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules , 2004, Cell.

[63]  J. Yates,et al.  A model for random sampling and estimation of relative protein abundance in shotgun proteomics. , 2004, Analytical chemistry.

[64]  Alejandro Chavez,et al.  Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[65]  D. Rubinsztein,et al.  Decreased cAMP Response Element-mediated Transcription AN EARLY EVENT IN EXON 1 AND FULL-LENGTH CELL MODELS OF HUNTINGTON S DISEASE THAT CONTRIBUTES TO POLYGLUTAMINE PATHOGENESIS* , 2004 .

[66]  Y. Chernoff,et al.  Aggregation of Expanded Polyglutamine Domain in Yeast Leads to Defects in Endocytosis , 2003, Molecular and Cellular Biology.

[67]  H. Zoghbi,et al.  Interaction of Akt-Phosphorylated Ataxin-1 with 14-3-3 Mediates Neurodegeneration in Spinocerebellar Ataxia Type 1 , 2003, Cell.

[68]  Effat S. Emamian,et al.  Serine 776 of Ataxin-1 Is Critical for Polyglutamine-Induced Disease in SCA1 Transgenic Mice , 2003, Neuron.

[69]  A. Barabasi,et al.  Hierarchical Organization of Modularity in Metabolic Networks , 2002, Science.

[70]  Fabrice P Cordelières,et al.  The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt. , 2002, Developmental cell.

[71]  L. Raymond,et al.  Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease , 2002, Neuron.

[72]  A. Matsukage,et al.  Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration , 2002, Cell Death and Differentiation.

[73]  Hierarchical Organization of Modularity in Metabolic Networks Supporting Online Material , 2002 .

[74]  C. Ross,et al.  Isolation of a 40-kDa Huntingtin-associated Protein* , 2001, The Journal of Biological Chemistry.

[75]  S. Grant,et al.  Proteomic analysis of NMDA receptor–adhesion protein signaling complexes , 2000, Nature Neuroscience.

[76]  N. Severs,et al.  CONNEXIN EXPRESSION IN HUNTINGTON'S DISEASED HUMAN BRAIN , 1998, Cell biology international.

[77]  Manish S. Shah,et al.  A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes , 1993, Cell.

[78]  Joseph B. Martin Huntington's disease , 1984, Neurology.