Robust border enhancement and detection for measurement of fetal nuchal translucency in ultrasound images

Ultrasonic measurement of nuchal translucency (NT) thickness in the first trimester of pregnancy has recently been proposed as the most useful marker in early screening for fetal chromosomal abnormalities. However, manual tracing of the two echogenic lines in the image, using on-screen calipers, is hampered by weak edges, together with noise and other artifacts, leading to variable results and inefficiency. Our semi-automatic method of fetal NT thickness measurement uses a coherence-enhancing diffusion filter to enhance the border and reduce noise, followed by detection of the NT by minimization of a cost function, that combines intensity, edge strength and continuity, using dynamic programming. This method has been validated by determining the correlation between manual and semi-automatic measurements.

[1]  Jitendra Malik,et al.  Scale-Space and Edge Detection Using Anisotropic Diffusion , 1990, IEEE Trans. Pattern Anal. Mach. Intell..

[2]  K. Nicolaides,et al.  The 11-14 week scan: the diagnosis of fetal abnormalities , 1999 .

[3]  K. Nicolaides,et al.  Cardiac defects in 1st-trimester fetuses with trisomy 18. , 1995, Fetal diagnosis and therapy.

[4]  J. Bernardes,et al.  Semiautomated ultrasonographic measurement of fetal nuchal translucency using a computer software tool. , 1998, Ultrasound in medicine & biology.

[5]  K. Nicolaides,et al.  UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10–14 weeks of gestation , 1998, The Lancet.

[6]  Joachim Weickert,et al.  Coherence-Enhancing Diffusion Filtering , 1999, International Journal of Computer Vision.

[7]  A. Suvichakorn,et al.  Fast edge-preserving noise reduction for ultrasound images , 2000, 2000 IEEE Nuclear Science Symposium. Conference Record (Cat. No.00CH37149).

[8]  Quan Liang,et al.  A dynamic programming procedure for automated ultrasonic measurement of the carotid artery , 1994, Computers in Cardiology 1994.

[9]  Yasser M. Kadah,et al.  Real-time speckle reduction and coherence enhancement in ultrasound imaging via nonlinear anisotropic diffusion , 2002, IEEE Transactions on Biomedical Engineering.

[10]  Fionnuala McAuliffe,et al.  Detection of fetal structural abnormalities with US during early pregnancy. , 2004, Radiographics : a review publication of the Radiological Society of North America, Inc.

[11]  Mubarak Shah,et al.  A Fast algorithm for active contours and curvature estimation , 1992, CVGIP Image Underst..

[12]  Tomas Gustavsson,et al.  A multiscale dynamic programming procedure for boundary detection in ultrasonic artery images , 2000, IEEE Transactions on Medical Imaging.

[13]  Christos P. Loizou,et al.  Snakes based segmentation of the common carotid artery intima media , 2007, Medical & Biological Engineering & Computing.

[14]  Alfred Abuhamad,et al.  Technical aspects of nuchal translucency measurement. , 2005, Seminars in perinatology.

[15]  Hans Burkhardt,et al.  Using snakes to detect the intimal and adventitial layers of the common carotid artery wall in sonographic images , 2002, Comput. Methods Programs Biomed..

[16]  K. Nicolaides,et al.  Outcome of pregnancy in chromosomally normal fetuses with increased nuchal translucency in the first trimester , 2001, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[17]  T Gustavsson,et al.  A new automated computerized analyzing system simplifies readings and reduces the variability in ultrasound measurement of intima-media thickness. , 1997, Stroke.

[18]  M. Bebbington,et al.  Detection of congenital heart disease in the first trimester of pregnancy , 2006 .

[19]  K. Nicolaides,et al.  Early diagnosis of major cardiac defects in chromosomally normal fetuses with increased nuchal translucency , 1999, British journal of obstetrics and gynaecology.