Correlation of Fine Needle Aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule

Background. Fine needle aspiration cytology is considered the gold standard diagnostic test for the diagnosis of thyroid nodules. Fine needle aspiration cytology is a cost effective procedure that provides specific diagnosis rapidly with minimal complications. Based on the cytology findings, patients can be followed in cases of benign diagnosis and subjected to surgery in cases of malignant diagnosis thereby decreasing the rate of unnecessary surgery. Purpose of the present study was to correlate the fine needle aspiration cytology findings with histopathology of excised specimens. Material and Methods. This was a prospective study conducted on 75 consecutive patients between January 2003 and December 2005. All patients with clinically diagnosed solitary thyroid nodule who were clinically and biochemically euthyroid were included for study. Patients with multinodular goitre and who were hypothyroid or hyperthyroid were excluded from the study. Results. The sensitivity, specificity, accuracy, false positive rate, false negative rate, positive predictive value, and negative predictive value of FNAC for the diagnosis of neoplastic solitary thyroid nodules were 80%, 86.6%, 13.3%, 20%, 80%, and 86.6%, respectively. Commonest malignancy detected was papillary carcinoma in 12 patients. Conclusions. Fine needle aspiration cytology is a simple, easy to perform, cost effective, and easily repeated procedure for the diagnosis of thyroid cancer. It is recommended as the first line investigation for the diagnosis of solitary thyroid nodule.

[1]  A. Fassina,et al.  FNA cytology and frozen section examination in patients with follicular lesions of the thyroid gland. , 2009, Anticancer research.

[2]  A. Proietti,et al.  Role of frozen section associated with intraoperative cytology in comparison to FNA and FS alone in the management of thyroid nodules. , 2007, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[3]  E. Eviatar,et al.  Accuracy and consistency of fine-needle aspiration biopsy in the diagnosis and management of solitary thyroid nodules. , 2005, The Israel Medical Association journal : IMAJ.

[4]  J. Serpell,et al.  Fine‐needle aspiration cytology of thyroid nodules: how useful is it? , 2003, ANZ journal of surgery.

[5]  Kevin Barraclough,et al.  I and i , 2001, BMJ : British Medical Journal.

[6]  H. Bonjer,et al.  Fine needle aspiration cytology of thyroid nodules: how accurate is it and what are the causes of discrepant cases? , 2001, Cytopathology : official journal of the British Society for Clinical Cytology.

[7]  J. Shah,et al.  Role of Fine-Needle Aspiration Biopsy and Frozen Section Analysis in the Surgical Management of Thyroid Tumors , 2001, Annals of Surgical Oncology.

[8]  M. Dottorini,et al.  Usefulness of fine‐needle aspiration in the diagnosis of thyroid carcinoma , 2000, Cancer.

[9]  Eva M. Wojcik,et al.  Fine‐needle aspiration of the thyroid: Rate and causes of cytohistopathologic discordance , 2000, Diagnostic cytopathology.

[10]  Y. Oertel Fine-needle aspiration and the diagnosis of thyroid cancer. , 1996, Endocrinology and metabolism clinics of North America.

[11]  N. Dorairajan,et al.  Solitary nodule of the thyroid and the role of fine needle aspiration cytology in diagnosis. , 1996, Journal of the Indian Medical Association.

[12]  S. Agrawal Diagnostic accuracy and role of fine needle aspiration cytology in management of thyroid nodules , 1995, Journal of surgical oncology.

[13]  H. Gharib,et al.  Fine-Needle Aspiration Biopsy of the Thyroid: An Appraisal , 1993, Annals of Internal Medicine.

[14]  A. Nahum,et al.  Surgical management of the thyroid nodule: Patient selection based on the results of fine‐needle aspiration cytology , 1992, The Laryngoscope.

[15]  S. Ewen,et al.  Management of isolated thyroid swellings: a prospective six year study of fine needle aspiration cytology in diagnosis. , 1990, BMJ.

[16]  N. Matheson,et al.  Fine needle aspiration cytology in isolated thyroid swellings: a prospective two year evaluation. , 1985, British medical journal.

[17]  M. Radetić,et al.  Reliability of Aspiration Biopsy in Thyroid Nodes: Study of 2190 Operated Patients , 1984, Tumori.

[18]  M. Singer,et al.  Role of needle biopsy in thyroid nodules. , 1983, Archives of otolaryngology.

[19]  S. Werner The Thyroid A Fundamental and Clinical Text , 1957 .