Early Diagnosis of Breast Cancer

Early-stage cancer detection could reduce breast cancer death rates significantly in the long-term. The most critical point for best prognosis is to identify early-stage cancer cells. Investigators have studied many breast diagnostic approaches, including mammography, magnetic resonance imaging, ultrasound, computerized tomography, positron emission tomography and biopsy. However, these techniques have some limitations such as being expensive, time consuming and not suitable for young women. Developing a high-sensitive and rapid early-stage breast cancer diagnostic method is urgent. In recent years, investigators have paid their attention in the development of biosensors to detect breast cancer using different biomarkers. Apart from biosensors and biomarkers, microwave imaging techniques have also been intensely studied as a promising diagnostic tool for rapid and cost-effective early-stage breast cancer detection. This paper aims to provide an overview on recent important achievements in breast screening methods (particularly on microwave imaging) and breast biomarkers along with biosensors for rapidly diagnosing breast cancer.

[1]  Jong-Gwan Yook,et al.  A planar split-ring resonator-based microwave biosensor for label-free detection of biomolecules , 2012 .

[2]  J. Benítez,et al.  Whole Exome Sequencing Suggests Much of Non-BRCA1/BRCA2 Familial Breast Cancer Is Due to Moderate and Low Penetrance Susceptibility Alleles , 2013, PloS one.

[3]  N. Misran,et al.  Compact Tapered-Shape Slot Antenna for UWB Applications , 2011, IEEE Antennas and Wireless Propagation Letters.

[4]  S. Metcalfe,et al.  P53 autoantibodies in 1006 patients followed up for breast cancer , 2000, Breast Cancer Research.

[5]  B. Zetter,et al.  Cancer biomarkers: knowing the present and predicting the future. , 2005, Future oncology.

[6]  Amin M. Abbosh,et al.  Microwave System for Head Imaging , 2014, IEEE Transactions on Instrumentation and Measurement.

[7]  A. Orlandi,et al.  Paradox CA 15-3 increase in metastatic breast cancer patients treated with everolimus: a change of paradigm in a case series. , 2016, Biomarkers in medicine.

[8]  Yunpeng Li,et al.  Microwave breast cancer detection via cost-sensitive ensemble classifiers: Phantom and patient investigation , 2017, Biomed. Signal Process. Control..

[9]  Xin Xu,et al.  Breast tumor detection using piezoelectric fingers: first clinical report. , 2013, Journal of the American College of Surgeons.

[10]  M. Duffy,et al.  CA 15-3 and Related Mucins as Circulating Markers in Breast Cancer , 1999, Annals of clinical biochemistry.

[11]  K. K. Adhikari,et al.  A reusable robust radio frequency biosensor using microwave resonator by integrated passive device technology for quantitative detection of glucose level. , 2015, Biosensors & bioelectronics.

[12]  Jong-Gwan Yook,et al.  Recent research trends of radio-frequency biosensors for biomolecular detection. , 2014, Biosensors & bioelectronics.

[13]  Xu Li,et al.  Microwave imaging via space-time beamforming for early detection of breast cancer , 2002, 2002 IEEE International Conference on Acoustics, Speech, and Signal Processing.

[14]  Shireen D. Geimer,et al.  Microwave tomography in the context of complex breast cancer imaging , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[15]  Armin Koch,et al.  Personalized medicine using DNA biomarkers: a review , 2012, Human Genetics.

[16]  Håkan Jonsson,et al.  Author reply , 2012 .

[17]  De-chun Zhang,et al.  Serum microRNA-21 as a potential diagnostic biomarker for breast cancer: a systematic review and meta-analysis , 2016, Clinical and Experimental Medicine.

[18]  J. Yook,et al.  Carbon-nanotube-resonator-based biosensors. , 2008, Small.

[19]  D. Katti,et al.  Combination of single walled carbon nanotubes/graphene oxide with paclitaxel: a reactive oxygen species mediated synergism for treatment of lung cancer. , 2013, Nanoscale.

[20]  T. Goswami,et al.  Optical Biosensors: A Revolution Towards Quantum Nanoscale Electronics Device Fabrication , 2011, Journal of biomedicine & biotechnology.

[21]  A. Stojadinovic,et al.  Future Directions for the Early Detection of Recurrent Breast Cancer , 2014, Journal of Cancer.

[22]  Jianing Li,et al.  The interplay between hospital and surgeon factors and the use of sentinel lymph node biopsy for breast cancer , 2016, Medicine.

[23]  Zhiqiang Gao,et al.  A highly sensitive microRNA biosensor based on ruthenium oxide nanoparticle-initiated polymerization of aniline. , 2010, Chemical communications.

[24]  Pheroze Tamboli,et al.  Limitations of preoperative biopsy in patients with metastatic renal cell carcinoma: comparison to surgical pathology in 405 cases , 2012, BJU international.

[25]  Jacques Beauvais,et al.  Plasmonic Propagations Distances for Interferometric Surface Plasmon Resonance Biosensing , 2022 .

[26]  H. Bhat,et al.  Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer , 2013, BMC Cancer.

[27]  A. Taflove,et al.  Three-dimensional FDTD analysis of an ultrawideband antenna-array element for confocal microwave imaging of nonpalpable breast tumors , 1999, IEEE Antennas and Propagation Society International Symposium. 1999 Digest. Held in conjunction with: USNC/URSI National Radio Science Meeting (Cat. No.99CH37010).

[29]  M. Mansourian,et al.  A Hybrid Computer-aided-diagnosis System for Prediction of Breast Cancer Recurrence (HPBCR) Using Optimized Ensemble Learning , 2016, Computational and structural biotechnology journal.

[30]  D. Herceg,et al.  Anti-p53 antibodies in serum: relationship to tumor biology and prognosis of breast cancer patients , 2010, Medical oncology.

[31]  David Gozal,et al.  Salivary biomarkers in the diagnosis of breast cancer: A review. , 2017, Critical reviews in oncology/hematology.

[32]  O. Yurduseven,et al.  Microwave imaging using indirect holographic techniques , 2014, IEEE Antennas and Propagation Magazine.

[33]  T. Wei,et al.  Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets. , 2014, Biomaterials.

[34]  Jorge S. Reis-Filho,et al.  Circulating tumour cells and cell-free DNA as tools for managing breast cancer , 2013, Nature Reviews Clinical Oncology.

[35]  R. Vermeulen,et al.  Early diagnostic protein biomarkers for breast cancer: how far have we come? , 2012, Breast Cancer Research and Treatment.

[36]  Jeremie Bourqui,et al.  A Prototype System for Measuring Microwave Frequency Reflections from the Breast , 2012, Int. J. Biomed. Imaging.

[37]  J. M. Sill,et al.  Preliminary investigations of tissue sensing adaptive radar for breast tumor detection , 2003, Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439).

[38]  W. Shih,et al.  Development of array piezoelectric fingers towards in vivo breast tumor detection. , 2016, The Review of scientific instruments.

[39]  Jong-Gwan Yook,et al.  A highly sensitive and label free biosensing platform for wireless sensor node system. , 2013, Biosensors & bioelectronics.

[40]  Magda El-Shenawee,et al.  Review of Electromagnetic Techniques for Breast Cancer Detection , 2011, IEEE Reviews in Biomedical Engineering.

[41]  Paul M. Meaney,et al.  A clinical prototype for active microwave imaging of the breast , 2000 .

[42]  Wei Li,et al.  Proteomics-based Identification of Human Acute Leukemia Antigens That Induce Humoral Immune Response* , 2005, Molecular & Cellular Proteomics.

[43]  Zuo-Min Tsai,et al.  Development of a multilayered polymeric DNA biosensor using radio frequency technology with gold and magnetic nanoparticles. , 2012, Biosensors & bioelectronics.

[44]  Lingling Xie,et al.  Electrochemical biosensor based on reduced graphene oxide and Au nanoparticles entrapped in chitosan/silica sol–gel hybrid membranes for determination of dopamine and uric acid , 2012 .

[45]  Lulu Wang,et al.  Three-Dimensional Far-Field Holographic Microwave Imaging: An Experimental Investigation of Dielectric Object , 2014 .

[46]  S. Andleeb,et al.  Blueprint of quartz crystal microbalance biosensor for early detection of breast cancer through salivary autoantibodies against ATP6AP1. , 2015, Biosensors & bioelectronics.

[47]  D. Dubuc,et al.  Microwave biosensor dedicated to the dielectric spectroscopy of a single alive biological cell in its culture medium , 2013, 2013 IEEE MTT-S International Microwave Symposium Digest (MTT).

[48]  Leslie A. Rusch,et al.  A Wearable Microwave Antenna Array for Time-Domain Breast Tumor Screening , 2016, IEEE Transactions on Medical Imaging.

[49]  Jiye Cai,et al.  A recyclable chitosan-based QCM biosensor for sensitive and selective detection of breast cancer cells in real time. , 2014, The Analyst.

[50]  Eduardo Andrés-León,et al.  Tumor microRNA expression profiling identifies circulating microRNAs for early breast cancer detection. , 2015, Clinical chemistry.

[51]  P. A. Rasheed,et al.  Graphene-DNA electrochemical sensor for the sensitive detection of BRCA1 gene , 2014 .

[52]  Robin Dapp,et al.  Comparing different ultrasound imaging methods for breast cancer detection , 2015, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control.

[53]  Michael J. Powell,et al.  Genetic alteration and mutation profiling of circulating cell-free tumor DNA (cfDNA) for diagnosis and targeted therapy of gastrointestinal stromal tumors , 2016, Chinese journal of cancer.

[54]  Longhua Guo,et al.  Highly Selective and Sensitive Electrochemiluminescence Biosensor for p53 DNA Sequence Based on Nicking Endonuclease Assisted Target Recycling and Hyperbranched Rolling Circle Amplification. , 2016, Analytical chemistry.

[55]  Qing Huo Liu,et al.  Microwave-Induced Thermal Acoustic Tomography for Breast Tumor Based on Compressive Sensing , 2013, IEEE Transactions on Biomedical Engineering.

[56]  M. Tewes,et al.  Microfabricated high-performance microwave impedance biosensors for detection of aptamer-protein interactions , 2005 .

[57]  P. G. C. Selwyna,et al.  Development of electrochemical biosensor for breast cancer detection using gold nanoparticle doped CA 15-3 antibody and antigen interaction , 2013, 2013 International Conference on Signal Processing , Image Processing & Pattern Recognition.

[58]  I. Brandslund,et al.  Serum HER-2: sensitivity, specificity, and predictive values for detecting metastatic recurrence in breast cancer patients , 2013, Journal of Cancer Research and Clinical Oncology.

[59]  Nan Sun,et al.  Palm NMR and 1-Chip NMR , 2011, IEEE Journal of Solid-State Circuits.

[60]  J. Edrich,et al.  Microwaves in breast cancer detection. , 1987, European journal of radiology.

[61]  Enrique Meléndez,et al.  Nanostructured gold dsDNA sensor for early detection of breast cancer by beta protein 1 (BP1). , 2015, Journal of electroanalytical chemistry.

[62]  David E. Misek,et al.  Protein Biomarkers for the Early Detection of Breast Cancer , 2011, International journal of proteomics.

[63]  Keith D Paulsen,et al.  Surface scanning through a cylindrical tank of coupling fluid for clinical microwave breast imaging exams. , 2012, Medical physics.

[64]  Geometric interpretation of Murphy bases and an application , 2011, 1101.2738.

[65]  Mostafa Azimzadeh,et al.  An electrochemical nanobiosensor for plasma miRNA-155, based on graphene oxide and gold nanorod, for early detection of breast cancer. , 2016, Biosensors & bioelectronics.

[66]  A. Preece,et al.  Experimental and clinical results of breast cancer detection using UWB microwave radar , 2008, 2008 IEEE Antennas and Propagation Society International Symposium.

[67]  A. Jemal,et al.  Breast Cancer Statistics , 2013 .

[68]  A. Negassa,et al.  A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk , 2011, Journal of oncology.

[69]  Victor J Pizzitola,et al.  Contrast‐enhanced Digital Mammography: A Single‐Institution Experience of the First 208 Cases , 2017, The breast journal.

[70]  Hiroyuki Konishi,et al.  Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells , 2011, Proceedings of the National Academy of Sciences.

[71]  R. Molina,et al.  Circulating levels of HER-2/neu oncoprotein in breast cancer , 2012, Clinical chemistry and laboratory medicine.

[72]  C. Smart Limitations of the randomized trial for the early detection of cancer , 1997, Cancer.

[73]  Lulu Wang,et al.  Imaging of 3-D Dielectric Objects Using Far-Field Holographic Microwave Imaging Technique , 2014 .

[74]  Amir H. Golnabi,et al.  Clinical microwave breast imaging — 2D results and the evolution to 3D , 2009, 2009 International Conference on Electromagnetics in Advanced Applications.

[75]  S. Barsky,et al.  Fiberoptic ductoscopy for breast cancer patients with nipple discharge , 2001, Surgical Endoscopy.

[76]  Yuzhong Zhang,et al.  Simultaneous fluoroimmunoassay of two tumor markers based on CdTe quantum dots and gold nanocluster coated-silica nanospheres as labels , 2015 .

[77]  Hikmat N. Daghestani,et al.  Theory and Applications of Surface Plasmon Resonance, Resonant Mirror, Resonant Waveguide Grating, and Dual Polarization Interferometry Biosensors , 2010, Sensors.

[78]  S. Sultana,et al.  HER-2 Positive Breast Cancer - a Mini-Review. , 2016, Asian Pacific journal of cancer prevention : APJCP.

[79]  David E. Misek,et al.  Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[80]  Håkan Jonsson,et al.  Effectiveness of population‐based service screening with mammography for women ages 40 to 49 years with a high or low risk of breast cancer: Socioeconomic status, parity, and age at birth of first child , 2015, Cancer.

[81]  L. Bharadwaj,et al.  Translocation and toxicity of docetaxel multi-walled carbon nanotube conjugates in mammalian breast cancer cells. , 2014, Journal of biomedical nanotechnology.

[82]  Mark Coates,et al.  An Early Clinical Study of Time-Domain Microwave Radar for Breast Health Monitoring , 2016, IEEE Transactions on Biomedical Engineering.

[83]  Aicheng Chen,et al.  Nanomaterials Based Electrochemical Sensors for Biomedical Applications , 2013 .

[84]  Sunil Mittal,et al.  Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies. , 2017, Biosensors & bioelectronics.

[85]  Dag Pavic,et al.  Breast MRI, digital mammography and breast tomosynthesis: comparison of three methods for early detection of breast cancer. , 2015, Bosnian journal of basic medical sciences.

[86]  Lulu Wang,et al.  Open-ended waveguide antenna for microwave breast cancer detection , 2013, 2013 IEEE International Workshop on Electromagnetics, Applications and Student Innovation Competition.

[87]  Rosa Scapaticci,et al.  A Compressive Sensing Approach for 3D Breast Cancer Microwave Imaging With Magnetic Nanoparticles as Contrast Agent , 2016, IEEE Transactions on Medical Imaging.

[88]  S. Arya,et al.  Anti-EpCAM modified LC-SPDP monolayer on gold microelectrode based electrochemical biosensor for MCF-7 cells detection. , 2013, Biosensors & bioelectronics.

[89]  Seho Park,et al.  Elevated levels of serum tumor markers CA 15-3 and CEA are prognostic factors for diagnosis of metastatic breast cancers , 2013, Breast Cancer Research and Treatment.

[90]  Ruo Yuan,et al.  Novel immunoassay for carcinoembryonic antigen based on protein A-conjugated immunosensor chip by surface plasmon resonance and cyclic voltammetry , 2006, Bioprocess and biosystems engineering.

[91]  Kun Wang,et al.  A novel electrochemical biosensor based on polyadenine modified aptamer for label-free and ultrasensitive detection of human breast cancer cells. , 2017, Talanta.

[92]  Circulating DNA as biomarker in breast cancer , 2015, Breast Cancer Research.

[93]  Arn Migowski [Early detection of breast cancer and the interpretation of results of survival studies]. , 2015, Ciencia & saude coletiva.

[94]  F. Rosei,et al.  Size Dependence of Temperature-Related Optical Properties of PbS and PbS/CdS Core/Shell Quantum Dots , 2014 .

[95]  Tracy Onega,et al.  Facility Mammography Volume in Relation to Breast Cancer Screening Outcomes , 2016, Journal of medical screening.

[96]  Rihab Nasr,et al.  MicroRNAs as biomarkers for early breast cancer diagnosis, prognosis and therapy prediction , 2017, Pharmacology & therapeutics.

[97]  Giulio Giovannetti,et al.  Finite element method‐based approach for radiofrequency magnetic resonance coil losses estimation , 2016 .

[98]  Bernd Becker,et al.  A survey of the 2006–2009 quartz crystal microbalance biosensor literature , 2011, Journal of molecular recognition : JMR.

[99]  J. Wildberger,et al.  Contrast enhanced mammography: techniques, current results, and potential indications. , 2013, Clinical radiology.

[100]  Isabella Castiglioni,et al.  MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer , 2015, Theranostics.

[101]  C. D'Orsi,et al.  Diagnostic Performance of Digital Versus Film Mammography for Breast-Cancer Screening , 2005, The New England journal of medicine.

[102]  R. Benjamin,et al.  Development and application of a UWB radar system for breast imaging , 2008, 2008 Loughborough Antennas and Propagation Conference.

[103]  L. Philpotts,et al.  Breast ultrasonography: state of the art. , 2013, Radiology.

[104]  H. Nelson,et al.  Screening for Breast Cancer: An Update for the U.S. Preventive Services Task Force , 2009, Annals of Internal Medicine.

[105]  Banshi D. Gupta,et al.  SPR based fibre optic biosensor for phenolic compounds using immobilization of tyrosinase in polyacrylamide gel , 2013 .

[106]  Da Xing,et al.  Ultrashort Microwave-Pumped Real-Time Thermoacoustic Breast Tumor Imaging System , 2016, IEEE Transactions on Medical Imaging.

[107]  Marek E. Bialkowski,et al.  Compact Tapered Slot Antennas for UWB microwave imaging applications , 2010, 18-th INTERNATIONAL CONFERENCE ON MICROWAVES, RADAR AND WIRELESS COMMUNICATIONS.

[108]  Characterization of the Escherichia coli SSB-113 mutant single-stranded DNA-binding protein. Cloning of the gene, DNA and protein sequence analysis, high pressure liquid chromatography peptide mapping, and DNA-binding studies. , 1984, The Journal of biological chemistry.

[109]  Jacqueline Capeau,et al.  Mitochondrial DNA Content, an Inaccurate Biomarker of Mitochondrial Alteration in Human Immunodeficiency Virus-Related Lipodystrophy , 2008, Antimicrobial Agents and Chemotherapy.

[110]  Edward Jones,et al.  A Preprocessing Filter for Multistatic Microwave Breast Imaging for Enhanced Tumour Detection , 2014 .