N‐linked glycan truncation causes enhanced clearance of plasma‐derived von Willebrand factor

Essentials von Willebrands factor (VWF) glycosylation plays a key role in modulating in vivo clearance. VWF glycoforms were used to examine the role of specific glycan moieties in regulating clearance. Reduction in sialylation resulted in enhanced VWF clearance through asialoglycoprotein receptor. Progressive VWF N‐linked glycan trimming resulted in increased macrophage‐mediated clearance.

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