DISEASE IN WILDLIFE OR EXOTIC SPECIES Sphingomyelin Lipidosis ( Niemann e Pick Disease ) in a Juvenile Raccoon ( Procyon lotor )

A wild caught juvenile male raccoon with neurological disease was humanely destroyed due to poor prognosis. Necropsy examination revealed hepatomegaly, splenomegaly and multicentric lymphadenomegaly with diffuse hepatic pallor and pulmonary consolidation with pinpoint pale subpleural foci. Microscopically, there wasmarked pale cytoplasmic swelling of the central and peripheral neurons as well as the glial cells in the brain, accompanied by multiorgan infiltration by abundant foamy macrophages. Ultrastructural investigation revealed accumulation of concentrically arranged lamellar material within lysosomes of the affected neurons, macrophages and endothelial cells. Biochemical enzymatic analysis detected sphingomyelinase deficiency and lysosomal storage disease consistent with sphingomyelin lipidosis (NiemannePick disease [NPD]) was diagnosed. This is the first report of NPD in a raccoon. 2013 Elsevier Ltd. All rights reserved.

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