Continuous separation of particles in a PDMS microfluidic channel via travelling surface acoustic waves (TSAW).

We demonstrate a simple and efficient device for the continuous label-free separation of microparticles using travelling surface acoustic waves (TSAW). A focusing interdigitated unidirectional transducer released high frequency (133.3 MHz) TSAW normal to the fluid flow direction to segregate 3 μm particles from 10 μm particles with a separation efficiency of 100%. The TSAW based separator does not necessitate a tight alignment of the PDMS microchannel with the transducer.

[1]  N. Pamme,et al.  Continuous sorting of magnetic cells via on-chip free-flow magnetophoresis. , 2006, Lab on a chip.

[2]  M. Yamada,et al.  Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics. , 2005, Lab on a chip.

[3]  James Friend,et al.  Particle concentration and mixing in microdrops driven by focused surface acoustic waves , 2008 .

[4]  Richard M. White,et al.  DIRECT PIEZOELECTRIC COUPLING TO SURFACE ELASTIC WAVES , 1965 .

[5]  S.R. Fang,et al.  SAW focusing by circular-arc interdigital transducers on YZ-LiNbO/sub 3/ , 1989, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[6]  Achim Wixforth,et al.  Novel surface acoustic wave (SAW)-driven closed PDMS flow chamber , 2011, Microfluidics and Nanofluidics.

[7]  Daniel Ahmed,et al.  Focusing microparticles in a microfluidic channel with standing surface acoustic waves (SSAW). , 2008, Lab on a chip.

[8]  Sehyun Shin,et al.  Size-dependent microparticles separation through standing surface acoustic waves , 2011 .

[9]  D. Di Carlo,et al.  Intrinsic particle-induced lateral transport in microchannels , 2012, Proceedings of the National Academy of Sciences.

[10]  Lin Wang,et al.  Standing surface acoustic wave (SSAW) based multichannel cell sorting. , 2012, Lab on a chip.

[11]  A. Wixforth,et al.  Microfluidics for miniaturized laboratories on a chip. , 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

[12]  J. Kutter,et al.  Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter. , 2003, Lab on a chip.

[13]  James Friend,et al.  Double aperture focusing transducer for controlling microparticle motions in trapezoidal microchannels with surface acoustic waves , 2009 .

[14]  Tony Jun Huang,et al.  Surface acoustic wave (SAW) acoustophoresis: now and beyond. , 2012, Lab on a chip.

[15]  T. Laurell,et al.  Continuous separation of lipid particles from erythrocytes by means of laminar flow and acoustic standing wave forces. , 2005, Lab on a chip.

[16]  Jie Xu,et al.  Oscillating bubbles in teardrop cavities for microflow control , 2013 .

[17]  A. Abate,et al.  Surface acoustic wave (SAW) directed droplet flow in microfluidics for PDMS devices. , 2009, Lab on a chip.

[18]  T. Huang,et al.  Continuous particle separation in a microfluidic channel via standing surface acoustic waves (SSAW). , 2009, Lab on a chip.

[19]  Hyung Jin Sung,et al.  Enhancement by optical force of separation in pinched flow fractionation. , 2011, Lab on a chip.

[20]  Louis Vessot King,et al.  On the Acoustic Radiation Pressure on Spheres , 1934 .

[21]  D A Weitz,et al.  Surface acoustic wave actuated cell sorting (SAWACS). , 2010, Lab on a chip.

[22]  Henrik Bruus,et al.  Acoustofluidics 1: Governing equations in microfluidics. , 2011, Lab on a chip.

[23]  Babetta L. Marrone,et al.  Droplet translocation by focused surface acoustic waves , 2012 .

[24]  Jiang Zhe,et al.  Recent advances in particle and droplet manipulation for lab-on-a-chip devices based on surface acoustic waves. , 2011, Lab on a chip.

[25]  H. Lilja,et al.  Microfluidic, label-free enrichment of prostate cancer cells in blood based on acoustophoresis. , 2012, Analytical chemistry.

[26]  T. Laurell,et al.  Two-hundredfold volume concentration of dilute cell and particle suspensions using chip integrated multistage acoustophoresis. , 2012, Lab on a chip.

[27]  Martin Wiklund,et al.  Acoustofluidics 14: Applications of acoustic streaming in microfluidic devices. , 2012, Lab on a chip.

[28]  I-Kao Chiang,et al.  On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves , 2012, Proceedings of the National Academy of Sciences.

[29]  Thomas Franke,et al.  Sorting of solid and soft objects in vortices driven by surface acoustic waves , 2009, Microtechnologies.

[30]  Sehyun Shin,et al.  Density-dependent separation of encapsulated cells in a microfluidic channel by using a standing surface acoustic wave. , 2012, Biomicrofluidics.

[31]  Ion Stiharu,et al.  Interdigitated comb‐like electrodes for continuous separation of malignant cells from blood using dielectrophoresis , 2011, Electrophoresis.

[32]  Hyung Jin Sung,et al.  Cross-type optical particle separation in a microchannel. , 2008, Analytical chemistry.

[33]  Leslie Y Yeo,et al.  Unique fingering instabilities and soliton-like wave propagation in thin acoustowetting films , 2012, Nature Communications.

[34]  T. Franke,et al.  SAW-controlled drop size for flow focusing. , 2013, Lab on a chip.

[35]  J. Sturm,et al.  Continuous Particle Separation Through Deterministic Lateral Displacement , 2004, Science.

[36]  M. Yamada,et al.  Pinched flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel. , 2004, Analytical chemistry.

[37]  Abraham P. Lee,et al.  Lateral air cavities for microfluidic pumping with the use of acoustic energy , 2011 .

[38]  Sang Youl Yoon,et al.  Optofluidic particle manipulation in a liquid-core/liquid-cladding waveguide. , 2012, Optics express.

[39]  F. Dickert,et al.  Functionalized Polymers as Receptors for Detection of Cells , 2011 .

[40]  James Friend,et al.  Rapid fluid flow and mixing induced in microchannels using surface acoustic waves , 2009 .

[41]  Maulik V. Patel,et al.  Lateral cavity acoustic transducer as an on-chip cell/particle microfluidic switch. , 2012, Lab on a chip.

[42]  Jie Xu,et al.  Microbubble array for on-chip worm processing , 2013 .

[43]  Thomas Laurell,et al.  Acoustofluidics 8: applications of acoustophoresis in continuous flow microsystems. , 2012, Lab on a chip.

[44]  A. Mitchell,et al.  Dielectrophoresis for manipulation of micro/nano particles in microfluidic systems , 2009, Analytical and bioanalytical chemistry.

[45]  Martyn Hill,et al.  Acoustofluidics 17: theory and applications of surface acoustic wave devices for particle manipulation. , 2012, Lab on a chip.

[46]  Jie Xu,et al.  Oscillating bubbles: a versatile tool for lab on a chip applications. , 2012, Lab on a chip.

[47]  I-Kao Chiang,et al.  Three-dimensional continuous particle focusing in a microfluidic channel via standing surface acoustic waves (SSAW). , 2011, Lab on a chip.

[48]  H. Amini,et al.  Label-free cell separation and sorting in microfluidic systems , 2010, Analytical and bioanalytical chemistry.

[49]  A Lenshof,et al.  Acoustofluidics 5: Building microfluidic acoustic resonators. , 2012, Lab on a chip.

[50]  K. Yosioka,et al.  Acoustic radiation pressure on a compressible sphere , 1955 .

[51]  R. J. Kansy,et al.  An Analysis of SAW Interdigital Transducers with Internal Reflections and the Application to the Design of Single-Phase Unidirectional Transducers , 1982 .