B cell MALT lymphoma diagnosed by labial minor salivary gland biopsy in patients screened for Sjögren’s syndrome

CASE REPORT Three patients presented to the Sjögren's syndrome (SS) Clinic at the National Institute of Dental and Craniofacial Research for screening. The records of patients with SS with a diagnosis of lymphoma were examined to determine whether the diagnosis was made in any of the cases as a result of labial salivary gland (LSG) biopsies. All patients had typical features of primary SS according to the American-European Consensus Group criteria. B cell mucosa associated lymphoid tissue (MALT) lymphoma was diagnosed based upon the LSG biopsy. CONCLUSION This report underlines the advantages of performing LSG biopsies as a routine part of screening for SS, and shows that it may in some instances lead to early diagnosis of MALT lymphomas in patients who show no signs of pre-existing lymphoma.

[1]  R. Jonsson,et al.  Attenuated Apoptosis of B Cell Activating Factor–Expressing Cells in Primary Sjögren’s Syndrome , 2003, Laboratory Investigation.

[2]  S. De Vita,et al.  Preliminary classification of nonmalignant B cell proliferation in Sjögren's syndrome: perspectives on pathobiology and treatment based on an integrated clinico-pathologic and molecular study approach. , 2001, Blood cells, molecules & diseases.

[3]  D. Isenberg,et al.  Malignant lymphoma in primary Sjögren's syndrome: a multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's Syndrome. , 1999, Arthritis and rheumatism.

[4]  E. Schattner,et al.  Lymphoma B Cells Evade Apoptosis through the TNF Family Members BAFF/BLyS and APRIL1 , 2004, The Journal of Immunology.

[5]  X. Mariette,et al.  The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren’s syndrome , 2003, Annals of the rheumatic diseases.

[6]  H. Moutsopoulos,et al.  Malignant lymphoma in primary Sjogren's syndrome. , 2001, The Israel Medical Association journal : IMAJ.

[7]  O. Guntinas-Lichius,et al.  Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sjögren's syndrome. , 2003, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[8]  R. Jonsson,et al.  Current issues in Sjögren's syndrome. , 2002, Oral diseases.

[9]  J. Ioannidis,et al.  Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren's syndrome. , 2002, Arthritis and rheumatism.

[10]  N. Okada,et al.  Salivary Gland MALT Lymphoma Associated with Helicobacter pylori Infection in a Patient with Sjögren's Syndrome , 2000, The Journal of dermatology.

[11]  N. Harris.  Lymphoid proliferations of the salivary glands. , 1999, American journal of clinical pathology.

[12]  D. Isenberg,et al.  Mucosa-associated lymphoid tissue lymphomas in two patients with rheumatoid arthritis on second-line agents, and secondary Sjögren's syndrome. , 2000, Rheumatology.

[13]  R. Hoover,et al.  Increased risk of lymphoma in sicca syndrome. , 1978, Annals of internal medicine.

[14]  R. Jonsson,et al.  Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group , 2002, Annals of the rheumatic diseases.

[15]  M. Matoba,et al.  Mucosa-associated lymphoid tissue lymphoma in Sjögren's syndrome: initial and follow-up imaging features. , 2002, AJR. American journal of roentgenology.