Cytokines, bone remodeling, and estrogen deficiency: a 1998 update.

[1]  John P. Bilezikian,et al.  Principles of Bone Biology , 1996 .

[2]  A. Parfitt.  Osteonal and hemi‐osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone , 1994, Journal of cellular biochemistry.

[3]  Y. Goldman,et al.  Wag the Tail: Structural Dynamics of Actomyosin , 1998, Cell.

[4]  G. Passeri,et al.  Endogenous production of tumor necrosis factor by primary cultures of murine calvarial cells: influence on IL-6 production and osteoclast development. , 1994, Bone and mineral.

[5]  N. Franchimont,et al.  Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells. , 1997, The Journal of clinical investigation.

[6]  Makoto Sato,et al.  Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts , 1997, Cell.

[7]  Seamus J. Martin,et al.  Suppression of TNF-α-Induced Apoptosis by NF-κB , 1996, Science.

[8]  S. C. Lin,et al.  Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. , 1997, The Journal of clinical investigation.

[9]  H. Broxmeyer,et al.  Estrogen loss upregulates hematopoiesis in the mouse: a mediating role of IL-6. , 1995, Experimental hematology.

[10]  H. Broxmeyer,et al.  Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. , 1995, The Journal of clinical investigation.

[11]  K Yano,et al.  Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[12]  H. Steller.  Mechanisms and genes of cellular suicide , 1995, Science.

[13]  D. Baylink,et al.  Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling. , 1989, The Journal of clinical endocrinology and metabolism.

[14]  L. Bonewald,et al.  Role of transforming growth factor-beta in bone remodeling. , 1990, Clinical orthopaedics and related research.

[15]  G. Mundy,et al.  Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro. , 1986, Journal of immunology.

[16]  D. Rao,et al.  Effects of Ethnicity and Age or Menopause on the Remodeling and Turnover of Iliac Bone: Implications for Mechanisms of Bone Loss , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  A. Glasebrook,et al.  Identification of an Estrogen Response Element Activated by Metabolites of 17β-Estradiol and Raloxifene , 1996, Science.

[18]  K. Kasono,et al.  Inhibitory effect of interleukin-4 on osteoclast-like cell formation in mouse bone marrow culture. , 1993, Bone and mineral.

[19]  B. Riggs,et al.  Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women. , 1996, The Journal of clinical endocrinology and metabolism.

[20]  T. Martin,et al.  Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors , 1995, The Journal of experimental medicine.

[21]  T. Martin,et al.  The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures , 1996, The Journal of experimental medicine.

[22]  R. Kimble,et al.  Simultaneous block of interleukin-1 and tumor necrosis factor is required to completely prevent bone loss in the early postovariectomy period. , 1995, Endocrinology.

[23]  A. Parfitt,et al.  Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescence. , 1996, The Journal of clinical investigation.

[24]  A. Wetterwald,et al.  Role of colony‐stimulating factor‐1 in bone metabolism , 1994, Journal of cellular biochemistry.

[25]  M. Obinata,et al.  Establishment and characterization of bone marrow stromal cell lines that support osteoclastogenesis. , 1995, Endocrinology.

[26]  T. Katagiri,et al.  Subcloning of three osteoblastic cell lines with distinct differentiation phenotypes from the mouse osteoblastic cell line KS-4. , 1996, Bone.

[27]  D. Dempster,et al.  Osteoclast demise in the rat: physiological versus degenerative cell death , 1996, Experimental physiology.

[28]  Motonao Nakamura,et al.  Induction of IL‐6 production by bone marrow stromal cells on the adhesion of IL‐6‐dependent hematopoietic cells , 1996, Journal of cellular physiology.

[29]  T. Stokke,et al.  Transforming growth factor-beta potently inhibits the viability- promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells , 1995 .

[30]  B. Boyce,et al.  Apoptosis in bone physiology and disease. , 1997, Molecular pathology : MP.

[31]  T. Chambers,et al.  IL-10 modulates formation of osteoclasts in murine hemopoietic cultures. , 1996, Journal of immunology.

[32]  P. Roberson,et al.  Loss of estrogen upregulates osteoblastogenesis in the murine bone marrow. Evidence for autonomy from factors released during bone resorption. , 1998, The Journal of clinical investigation.

[33]  T. García,et al.  Involvement of CCAAT/enhancer-binding protein and nuclear factor-kappa B binding sites in interleukin-6 promoter inhibition by estrogens. , 1996, Molecular endocrinology.

[34]  B. Riggs,et al.  Estrogen inhibits interleukin‐6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[35]  L. Demers,et al.  Ovariectomy selectively reduces the concentration of transforming growth factor beta in rat bone: implications for estrogen deficiency-associated bone loss. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[36]  R. Rizzoli,et al.  Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency. , 1997, The Journal of clinical investigation.

[37]  R. Turner,et al.  Printed in U.S.A. Copyright © 1997 by The Endocrine Society The Effects of Orbital Spaceflight on Bone Histomorphometry and Messenger Ribonucleic Acid Levels for Bone Matrix Proteins and Skeletal Signaling Peptides in Ovariectomized Growing Rats* , 2022 .

[38]  T. Martin,et al.  Transforming growth factor beta 1 stimulates bone formation and resorption in an in-vivo model in rabbits. , 1995, Bone.

[39]  F. Ross,et al.  Estrogen Deficiency Increases the Ability of Stromal Cells to Support Murine Osteoclastogenesis via an Interleukin-1and Tumor Necrosis Factor-mediated Stimulation of Macrophage Colony-stimulating Factor Production* , 1996, The Journal of Biological Chemistry.

[40]  G. Roodman,et al.  Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. , 1995, The Journal of clinical investigation.

[41]  C. O’Brien,et al.  Isolation and Characterization of the Human gp130 Promoter , 1997, The Journal of Biological Chemistry.

[42]  Y. Koishihara,et al.  Endogenous bone‐resorbing factors in estrogen deficiency: Cooperative effects of IL‐1 and IL‐6 , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  G. Ciliberto,et al.  Interleukin‐6 deficient mice are protected from bone loss caused by estrogen depletion. , 1994, The EMBO journal.

[44]  R. Ziegler,et al.  Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement. , 1995, The Journal of clinical endocrinology and metabolism.

[45]  D. Vanderschueren,et al.  Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency. , 1992, Endocrinology.

[46]  I. Weissman,et al.  Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice , 1997, Cell.

[47]  B Stein,et al.  Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta , 1995, Molecular and cellular biology.

[48]  A. Parfitt,et al.  The effects of androgen deficiency on murine bone remodeling and bone mineral density are mediated via cells of the osteoblastic lineage. , 1997, Endocrinology.

[49]  S. Manolagas,et al.  Osteopontin expression by osteoclast and osteoblast progenitors in the murine bone marrow: demonstration of its requirement for osteoclastogenesis and its increase after ovariectomy. , 1997, Endocrinology.

[50]  A. Glasebrook,et al.  Correction: Raloxifene Response Needs More Than an Element , 1997, Science.

[51]  J. Lotem,et al.  Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes. , 1996, Leukemia.

[52]  M. Kumegawa,et al.  Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts , 1997, The Journal of experimental medicine.

[53]  J. Glowacki,et al.  In vitro secretion of cytokines by human bone marrow: effects of age and estrogen status. , 1998, The Journal of clinical endocrinology and metabolism.

[54]  E. Opas,et al.  The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates. , 1993, The Journal of clinical investigation.

[55]  David,et al.  17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. , 1994, The Journal of clinical investigation.

[56]  G. Karsenty,et al.  Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation , 1997, Cell.

[57]  H. Okamura,et al.  Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. , 1997 .

[58]  E. Jimi,et al.  Interleukin-1 Activates an NF-B-like Factor in Osteoclast-like Cells (*) , 1996, The Journal of Biological Chemistry.

[59]  M. Sato,et al.  Estrogen and raloxifene stimulate transforming growth factor-beta 3 gene expression in rat bone: a potential mechanism for estrogen- or raloxifene-mediated bone maintenance. , 1996, Endocrinology.

[60]  G. Mundy,et al.  Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β , 1996, Nature Medicine.

[61]  T. Martin,et al.  Mechanisms by which cells of the osteoblast lineage control osteoclast formation and activity , 1994, Journal of cellular biochemistry.

[62]  G. Stamatoyannopoulos,et al.  The molecular basis of blood diseases , 1987 .

[63]  G. Mbalaviele,et al.  Short‐term local injections of transforming growth factor‐β1 decrease ovariectomy‐stimulated osteoclastic resorption in vivo in rats , 1995 .

[64]  D. Vanderschueren,et al.  Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. , 1997 .

[65]  C. Dinarello,et al.  Biologic basis for interleukin-1 in disease. , 1996, Blood.

[66]  R. Jilka,et al.  Inhibition of parathormone-stimulated bone resorption by type I interferon. , 1984, Biochemical and biophysical research communications.

[67]  S. Akira,et al.  Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor , 1997, The Journal of Steroid Biochemistry and Molecular Biology.

[68]  R. Derynck,et al.  Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype , 1996, The Journal of cell biology.

[69]  H. Broxmeyer,et al.  Increased osteoclast development after estrogen loss: mediation by interleukin-6 , 1992 .

[70]  R. Turner,et al.  Androgen treatment prevents loss of cancellous bone in the orchidectomized rat , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[71]  T. Hirano,et al.  IL-6 is produced by osteoblasts and induces bone resorption. , 1990, Journal of immunology.

[72]  Chawnshang Chang,et al.  Inhibition of NFκB Activity through Maintenance of IκBα Levels Contributes to Dihydrotestosterone-mediated Repression of the Interleukin-6 Promoter* , 1996, The Journal of Biological Chemistry.