Photodynamic therapy influence on anti-cancer immunity

The system of partial differential equations describing tumor-immune dynamics with angiogenesis taken into account is presented. For spatially homogeneous case, the steady state analysis of the model is carried out. The effects of single photodynamic impact are numerically simulated. In the case of strong immune response we found that the photodynamic therapy (PDT) gives rise to the substantial shrinkage of tumor size which is accompanied by the increase of IL-2 concentration. On the contrary, the photodynamic stimulation of weak immune response is shown to be insufficient to reduce the tumor. These findings indicate the important role of anti-cancer immune response in the long-term tumor control after PDT.

[1]  A. Welch,et al.  A review of the optical properties of biological tissues , 1990 .

[2]  S. Gollnick,et al.  CD8+ T cell-mediated control of distant tumours following local photodynamic therapy is independent of CD4+ T cells and dependent on natural killer cells , 2007, British Journal of Cancer.

[3]  H. Kiss,et al.  The Transfer of Interleukin‐8 Across the Human Placenta Perfused In Vitro , 1996, Obstetrics and gynecology.

[4]  N. G. Mironova,et al.  A mathematical model of the photodynamic fullerene-oxygen action on biological tissues , 2005 .

[5]  A. Krasnovskiî.  SINGLET MOLECULAR OXYGEN AND PRIMARY MECHANISMS OF PHOTODYNAMIC ACTION OF OPTICAL RADIATION , 1990 .

[6]  O. G. Isaeva,et al.  Modelling of anti-tumour immune response: Immunocorrective effect of weak centimetre electromagnetic waves , 2009 .

[7]  R J Jarvis,et al.  A mathematical analysis of a model for tumour angiogenesis , 1995, Journal of mathematical biology.

[8]  P. Hahnfeldt,et al.  Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy. , 1999, Cancer research.

[9]  D. Carbone,et al.  VEGF as a mediator of tumor-associated immunodeficiency , 2001, Immunologic research.

[10]  Q. Peng,et al.  Photodynamic Therapy , 1988, Methods in Molecular Biology.

[11]  D. Kirschner,et al.  A mathematical model of tumor-immune evasion and siRNA treatment , 2003 .

[12]  Jonathan A. Sherratt,et al.  Models of epidermal wound healing , 1990, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[13]  M. Korbelik,et al.  Photodynamic therapy-mediated immune response against subcutaneous mouse tumors. , 1999, Cancer research.

[14]  Mark A J Chaplain,et al.  Mathematical modelling of the spatio-temporal response of cytotoxic T-lymphocytes to a solid tumour. , 2004, Mathematical medicine and biology : a journal of the IMA.

[15]  M A Rupnick,et al.  Chemotaxis of human microvessel endothelial cells in response to acidic fibroblast growth factor. , 1990, Laboratory investigation; a journal of technical methods and pathology.