18. The Mechanisms and Therapeutic Consequences of Amine-Containing Drug Sequestration in Lysosomes
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[1] Dan Fu,et al. Imaging the Intracellular Distribution of Tyrosine Kinase Inhibitors in Living Cells with Quantitative Hyperspectral Stimulated Raman Scattering , 2014, Nature chemistry.
[2] J. Krise,et al. Amine-containing molecules and the induction of an expanded lysosomal volume phenotype: a structure-activity relationship study. , 2014, Journal of pharmaceutical sciences.
[3] G. Koning,et al. Intact Doxil is taken up intracellularly and released doxorubicin sequesters in the lysosome: evaluated by in vitro/in vivo live cell imaging. , 2013, Journal of controlled release : official journal of the Controlled Release Society.
[4] J. Krise,et al. Evaluating the roles of autophagy and lysosomal trafficking defects in intracellular distribution-based drug-drug interactions involving lysosomes. , 2013, Journal of pharmaceutical sciences.
[5] Cheng-Chung Chang,et al. Chemical principles for the design of a novel fluorescent probe with high cancer-targeting selectivity and sensitivity. , 2013, Integrative biology : quantitative biosciences from nano to macro.
[6] M. Forrest,et al. Lysosomotropic Properties of Weakly Basic Anticancer Agents Promote Cancer Cell Selectivity In Vitro , 2012, PloS one.
[7] J. Krise,et al. Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume: implications for an intracellular distribution-based drug interaction. , 2012, Molecular pharmaceutics.
[8] Yvonne Will,et al. A high content screening assay for identifying lysosomotropic compounds. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.
[9] P. Tripal,et al. Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system , 2010, Journal of cellular physiology.
[10] B. Samuelsson,et al. The resorptive apparatus of osteoclasts supports lysosomotropism and increases potency of basic versus non-basic inhibitors of cathepsin K. , 2010, Bone.
[11] M. Forrest,et al. The Role of Lysosomes in Limiting Drug Toxicity in Mice , 2010, Journal of Pharmacology and Experimental Therapeutics.
[12] R. Rajewski,et al. Mechanisms of amine accumulation in, and egress from, lysosomes. , 2009, Bioanalysis.
[13] J. Kornhuber,et al. Quantitative modeling of selective lysosomal targeting for drug design , 2008, European Biophysics Journal.
[14] Xinyuan Zhang,et al. Simulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic monobasic amines , 2008, J. Comput. Aided Mol. Des..
[15] A. Bielawska,et al. Novel analogs of D-e-MAPP and B13. Part 1: synthesis and evaluation as potential anticancer agents. , 2008, Bioorganic & medicinal chemistry.
[16] A. Bielawska,et al. Novel analogs of D-e-MAPP and B13. Part 2: signature effects on bioactive sphingolipids. , 2008, Bioorganic & medicinal chemistry.
[17] L. Duong,et al. Effect of Cathepsin K Inhibitor Basicity on in Vivo Off-Target Activities , 2008, Molecular Pharmacology.
[18] Jeffrey P Krise,et al. Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications. , 2007, Journal of pharmaceutical sciences.
[19] Zhiyang Zhao,et al. Lysosomes Contribute to Anomalous Pharmacokinetic Behavior of Melanocortin-4 Receptor Agonists , 2007, Pharmaceutical Research.
[20] A. Bielawska,et al. Tailoring structure-function and targeting properties of ceramides by site-specific cationization. , 2006, Bioorganic & medicinal chemistry.
[21] M. Percival,et al. The Consequences of Lysosomotropism on the Design of Selective Cathepsin K Inhibitors , 2006, Chembiochem : a European journal of chemical biology.
[22] B. Blagg,et al. A new approach for enhancing differential selectivity of drugs to cancer cells. , 2006, ACS chemical biology.
[23] W. Weglicki,et al. Iron Uptake and Release by Macrophages is Sensitive to Propranolol , 2006, Molecular and Cellular Biochemistry.
[24] Richard W. Horobin,et al. Fluorescent cationic probes for nuclei of living cells: why are they selective? A quantitative structure–activity relations analysis , 2006, Histochemistry and Cell Biology.
[25] J. Krise,et al. A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells. , 2005, Biochemistry.
[26] J. Falgueyret,et al. Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity. , 2005, Journal of medicinal chemistry.
[27] Muralikrishna Duvvuri,et al. A novel assay reveals that weakly basic model compounds concentrate in lysosomes to an extent greater than pH-partitioning theory would predict. , 2005, Molecular pharmaceutics.
[28] Malcolm Rowland,et al. Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat. , 2005, Journal of pharmaceutical sciences.
[29] E. Arriaga,et al. Selective determination of the doxorubicin content of individual acidic organelles in impure subcellular fractions. , 2005, Analytical chemistry.
[30] Yaoquan Liu,et al. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. , 2004, Bioorganic & medicinal chemistry.
[31] S. Kellokumpu,et al. Defective Acidification of Intracellular Organelles Results in Aberrant Secretion of Cathepsin D in Cancer Cells* , 2004, Journal of Biological Chemistry.
[32] Muralikrishna Duvvuri,et al. Weak Base Permeability Characteristics Influence the Intracellular Sequestration Site in the Multidrug-resistant Human Leukemic Cell Line HL-60* , 2004, Journal of Biological Chemistry.
[33] J. Falgueyret,et al. Quantitation of the lysosomotropic character of cationic amphiphilic drugs using the fluorescent basic amine Red DND-99. , 2004, Analytical biochemistry.
[34] Muralikrishna Duvvuri,et al. Separate Roles for the Golgi Apparatus and Lysosomes in the Sequestration of Drugs in the Multidrug-resistant Human Leukemic Cell Line HL-60* , 2003, Journal of Biological Chemistry.
[35] A. Vandewalle,et al. Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells. , 2003, The Biochemical journal.
[36] W. Daniel,et al. Intracellular distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping , 2001, British journal of pharmacology.
[37] M. Roberts,et al. Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process. , 2001, The Journal of pharmacology and experimental therapeutics.
[38] K. Yokogawa,et al. Uptake of imipramine in rat liver lysosomes in vitro and its inhibition by basic drugs. , 2000, The Journal of pharmacology and experimental therapeutics.
[39] M. Foley,et al. Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents. , 1998, Pharmacology & therapeutics.
[40] S. Simon,et al. Defective Acidification in Human Breast Tumor Cells and Implications for Chemotherapy , 1998, The Journal of experimental medicine.
[41] W. Daniel,et al. Interactions between promazine and antidepressants at the level of cellular distribution. , 1997, Pharmacology & toxicology.
[42] S. Simon,et al. Defective pH regulation of acidic compartments in human breast cancer cells (MCF-7) is normalized in adriamycin-resistant cells (MCF-7adr). , 1996, Biochemistry.
[43] J. Skehel,et al. Structure of influenza haemagglutinin at the pH of membrane fusion , 1994, Nature.
[44] S. Simon,et al. Cell biological mechanisms of multidrug resistance in tumors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[45] G. Dubowchik,et al. Reversal of doxorubicin resistance and catalytic neutralization of lysosomes by a lipophilic imidazole. , 1994, Biochimica et biophysica acta.
[46] S. Simon,et al. Intracellular pH and the control of multidrug resistance. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[47] J. Lecerf,et al. Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts. , 1992, The Journal of biological chemistry.
[48] Thomas J. Raub,et al. Primaquine blocks transport by inhibiting the formation of functional transport vesicles. Studies in a cell-free assay of protein transport through the Golgi apparatus. , 1991, The Journal of biological chemistry.
[49] Richard W. Horobin,et al. Predicting the behaviour and selectivity of fluorescent probes for lysosomes and related structures by means of structure-activity models , 1991, The Histochemical Journal.
[50] E. Crivellato,et al. Effect of lysosomotropic and membrane active substances on adriamycin uptake and histamine release. , 1990, Anticancer research.
[51] A. Alcamí,et al. The entry of African swine fever virus into Vero cells. , 1989, Virology.
[52] M. Forgac. Structure and function of vacuolar class of ATP-driven proton pumps. , 1989, Physiological reviews.
[53] D. Cutler,et al. The potential role of lysosomes in tissue distribution of weak bases , 1988, Biopharmaceutics & drug disposition.
[54] W. Klohs,et al. The effect of lysosomotropic agents and secretory inhibitors on anthracycline retention and activity in multiple drug-resistant cells. , 1988, Molecular pharmacology.
[55] H L Pearce,et al. Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells. , 1988, Molecular pharmacology.
[56] D. Cutler,et al. Role of lysosomes in hepatic accumulation of chloroquine. , 1988, Journal of pharmaceutical sciences.
[57] G. Cramb,et al. Selective lysosomal uptake and accumulation of the beta-adrenergic antagonist propranolol in cultured and isolated cell systems. , 1986, Biochemical pharmacology.
[58] M. Kobayashi,et al. Lysosomotropic agents reverse multiple drug resistance in human cancer cells. , 1986, Cancer letters.
[59] M. Hollingdale,et al. Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells. , 1985, Molecular and biochemical parasitology.
[60] K. von Figura,et al. Tilorone acts as a lysosomotropic agent in fibroblasts. , 1984, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.
[61] E Griffiths,et al. Cell killing by lysosomotropic detergents , 1983, The Journal of cell biology.
[62] R. Draper,et al. Monensin blocks the transport of diphtheria toxin to the cell cytoplasm , 1982, The Journal of cell biology.
[63] B Poole,et al. Cytoplasmic vacuolation of mouse peritoneal macrophages and the uptake into lysosomes of weakly basic substances , 1981, The Journal of cell biology.
[64] P. Tulkens,et al. Uptake and subcellular localization of daunorubicin and adriamycin in cultured fibroblasts. , 1978, European journal of cancer.
[65] P. Tulkens,et al. Commentary. Lysosomotropic agents. , 1974, Biochemical pharmacology.
[66] L. Mallucci,et al. HISTOCHEMICAL STUDIES OF LYSOSOMES AND LYSOSOMAL ENZYMES IN VIRUS-INFECTED CELL CULTURES , 1965, The Journal of experimental medicine.
[67] A. Allison,et al. UPTAKE OF DYES AND DRUGS BY LIVING CELLS IN CULTURE. , 1964, Life sciences.
[68] Greg J. Loewen,et al. Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells) , 2013 .
[69] E. Hempelmann,et al. Erratum to: From methylene blue to chloroquine: A brief review of the development of an antimalarial therapy , 2012, Parasitology Research.
[70] K. Schultz,et al. The lysosomotropic amines, chloroquine and hydroxychloroquine: a potentially novel therapy for graft-versus-host disease. , 1997, Leukemia & lymphoma.
[71] A. Helenius,et al. Inhibition of Semliki forest virus penetration by lysosomotropic weak bases. , 1982, The Journal of general virology.