Control over vesicle rupture and leakage by membrane packing and by the aggregation state of an attacking surfactant
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Triton X-100 (T) in its monomeric form has been found to induce the leakage of 5(6)-carboxyfluorescein (CF) from tightly packed gel-phase vesicles derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, 25 o C). In contrast, micellar solutions of T were found to promote the catastrophic rupture ofr the membrane. These conclusions are based on an analysis of the fluorescence self-quenching efficiency of recovered vesicular CF after incubation with T, below an its critical micelle concentration