Microgravity induces prostaglandin E2 and interleukin-6 production in normal rat osteoblasts: role in bone demineralization.

[1]  H. Akiyama,et al.  An improved quantitative RT-PCR fluorescent method for analysis of gene transcripts in the STS-65 space shuttle experiment. , 1996, Journal of biotechnology.

[2]  L. Lanyon,et al.  Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  M. Polan,et al.  Gonadal steroids modulate interleukin-1 receptor antagonist mRNA expression in cultured human monocytes. , 1995, Biochemical and biophysical research communications.

[4]  L. Raisz,et al.  Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[5]  H. Kawaguchi,et al.  Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae. , 1994, Endocrinology.

[6]  H. Kawaguchi,et al.  Stimulation of prostaglandin e2 production by interleukin‐1α and transforming growth factor α in osteoblastic MC3T3‐E1 cells , 1994 .

[7]  Takato O. Yoshida,et al.  The biased Vγ gene usage in the synovial fluid of patients with rheumatoid arthritis , 1994 .

[8]  H. Kawaguchi,et al.  Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. , 1993, The Journal of biological chemistry.

[9]  Y. Xia,et al.  Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. , 1993, Archives of biochemistry and biophysics.

[10]  R. Pietrzyk,et al.  Alterations in renal stone risk factors after space flight. , 1993, The Journal of urology.

[11]  M. Horowitz.  Cytokines and estrogen in bone: anti-osteoporotic effects. , 1993, Science.

[12]  H. Broxmeyer,et al.  Increased osteoclast development after estrogen loss: mediation by interleukin-6 , 1992 .

[13]  J. Kato,et al.  Expression of estrogen receptor in the rat brain: Detection of its mRNA using reverse transcription-polymerase chain reaction , 1992, The Journal of Steroid Biochemistry and Molecular Biology.

[14]  A. Leblanc,et al.  Can the adult skeleton recover lost bone? , 1991, Experimental Gerontology.

[15]  J. den Hertog,et al.  Nuclear responses to protein kinase C signal transduction are sensitive to gravity changes. , 1991, Experimental cell research.

[16]  S. Yamamoto,et al.  cAMP-dependent induction of fatty acid cyclooxygenase mRNA in mouse osteoblastic cells (MC3T3-E1). , 1991, The Journal of biological chemistry.

[17]  B. Varnum,et al.  TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. , 1991, The Journal of biological chemistry.

[18]  J. Klein-Nulend,et al.  Mechanism of regulation of prostaglandin production by parathyroid hormone, interleukin-1, and cortisol in cultured mouse parietal bones. , 1991, Endocrinology.

[19]  P. Whitson,et al.  Hypergravity signal transduction in HeLa cells with concomitant phosphorylation of proteins immunoprecipitated with anti-microtubule-associated protein antibodies. , 1991, Experimental cell research.

[20]  T. Hirano,et al.  IL-6 is produced by osteoblasts and induces bone resorption. , 1990, Journal of immunology.

[21]  J. den Hertog,et al.  Microgravity decreases c-fos induction and serum response element activity. , 1990, Journal of cell science.

[22]  S. K. Ternovoi,et al.  [Study of the musculoskeletal system of the spine in humans after long-term space flights by the method of computerized tomography]. , 1990, Kosmicheskaia biologiia i aviakosmicheskaia meditsina.

[23]  L. Raisz,et al.  Effects of prostaglandin F2 alpha on bone formation and resorption in cultured neonatal mouse calvariae: role of prostaglandin E2 production. , 1990, Endocrinology.

[24]  D. Mirkin.  Space Physiology and Medicine , 1990 .

[25]  L. Aarden,et al.  Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: a possible role of interleukin-6 in osteoclastogenesis. , 1989, Biochemical and biophysical research communications.

[26]  F. D. Di Padova,et al.  Interleukin‐6 is produced by bone and modulated by parathyroid hormone , 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[27]  N. Kamata,et al.  Reduction of G1 phase duration and enhancement of c-myc gene expression in HeLa cells at hypergravity. , 1989, Journal of cell science.

[28]  M. Centrella,et al.  Interleukin-1 in combination with transforming growth factor-alpha produces enhanced bone resorption in vitro. , 1988, Endocrinology.

[29]  P. Nijweide,et al.  Stimulation of arachidonic acid metabolism in primary cultures of osteoblast-like cells by hormones and drugs. , 1984, Prostaglandins.

[30]  P. Price,et al.  The effect of transcriptional inhibitors on the bone gamma-carboxyglutamic acid protein response to 1,25-dihydroxyvitamin D3 in osteosarcoma cells. , 1984, The Journal of biological chemistry.

[31]  T. Wronski,et al.  Effect of spaceflight on periosteal bone formation in rats. , 1983, The American journal of physiology.

[32]  D B Kimmel,et al.  Effects of spaceflight on trabecular bone in rats. , 1983, The American journal of physiology.

[33]  G. Rodan,et al.  The effect of 1,25(OH)2D3 on alkaline phosphatase in osteoblastic osteosarcoma cells. , 1982, The Journal of biological chemistry.

[34]  M. McDonald.  Calculator program for weighted logit-log radioimmunoassay data reduction. , 1981, Clinical chemistry.

[35]  Kotovskaia Ar,et al.  [Principal results of physiological experiments with mammals aboard biosatellite "Cosmos-936"]. , 1980 .

[36]  R S Johnston,et al.  Prolonged weightlessness and calcium loss in man. , 1979, Acta astronautica.

[37]  E R Morey,et al.  Inhibition of bone formation during space flight. , 1978, Science.

[38]  M. Whittle,et al.  Bone mineral changes: the second manned Skylab mission. , 1976, Aviation, space, and environmental medicine.

[39]  Lawrence G. Raisz,et al.  Complement-Dependent Stimulation of Prostaglandin Synthesis and Bone Resorption , 1974, Science.

[40]  S. Arnaud,et al.  Skeletal responses to spaceflight. , 1991, Advances in space biology and medicine.

[41]  C. Fullmer,et al.  Calcium transport proteins, calcium absorption, and vitamin D. , 1983, Annual review of physiology.

[42]  H. DeLuca,et al.  Metabolism and mechanism of action of vitamin D. , 1976, Annual review of biochemistry.