MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients

Aims:  Mucus expectoration is a common feature of chronic obstructive pulmonary disease (COPD). MUC5AC and MUC5B, the major mucins, are released predominantly from submucosal glands in the central airways. The aim was to investigate gland size and MUC5AC and MUC5B expression in bronchial rings from smokers with COPD compared with control groups.

[1]  R. Wu,et al.  Regulation of airway mucin gene expression. , 2008, Annual review of physiology.

[2]  P. Burgel,et al.  A morphometric study of mucins and small airway plugging in cystic fibrosis , 2006, Thorax.

[3]  D. Jarvis,et al.  Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm. , 2007, American journal of respiratory and critical care medicine.

[4]  S. Lazarus,et al.  Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. , 2006, Chest.

[5]  S. Johnston,et al.  Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations. , 2006, American journal of respiratory and critical care medicine.

[6]  S. Sethi,et al.  Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease. , 2006, American journal of respiratory and critical care medicine.

[7]  I. Adcock,et al.  Alteration of adenosine receptors in patients with chronic obstructive pulmonary disease. , 2006, American journal of respiratory and critical care medicine.

[8]  P. Barnes,et al.  Treatment of airway mucus hypersecretion , 2006, Annals of medicine.

[9]  J. Voynow,et al.  Respiratory tract mucin genes and mucin glycoproteins in health and disease. , 2006, Physiological reviews.

[10]  B. Beghé,et al.  Decreased expression of TGF-β type II receptor in bronchial glands of smokers with COPD , 2005, Thorax.

[11]  J. Hogg,et al.  Convergence of the epidemiology and pathology of COPD , 2005, Thorax.

[12]  Michael Kay,et al.  Thurlbeck's Pathology of the Lung , 2005 .

[13]  N. Packer,et al.  Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. , 2005, The Biochemical journal.

[14]  J. Ward,et al.  Expression of ErbB receptors and mucins in the airways of long term current smokers , 2004, Thorax.

[15]  I. Adcock,et al.  Mucin expression in peripheral airways of patients with chronic obstructive pulmonary disease , 2004, Histopathology.

[16]  P. Paré,et al.  The nature of small-airway obstruction in chronic obstructive pulmonary disease. , 2004, The New England journal of medicine.

[17]  Y. Ho,et al.  Stimulation of Airway Mucin Gene Expression by Interleukin (IL)-17 through IL-6 Paracrine/Autocrine Loop* , 2003, The Journal of Biological Chemistry.

[18]  I. Adcock,et al.  Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD , 2002, European Respiratory Journal.

[19]  N. Alexis,et al.  Induced sputum derives from the central airways: confirmation using a radiolabeled aerosol bolus delivery technique. , 2001, American journal of respiratory and critical care medicine.

[20]  M. Copin,et al.  Normal respiratory mucosa, precursor lesions and lung carcinomas: differential expression of human mucin genes. , 2001, Frontiers in bioscience : a journal and virtual library.

[21]  L. Fabbri,et al.  Cellular and structural bases of chronic obstructive pulmonary disease. , 2001, American journal of respiratory and critical care medicine.

[22]  Michael B. Smith.  Carbohydrates , 2001, Public Health Nutrition.

[23]  R. Pauwels,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. , 2001, American journal of respiratory and critical care medicine.

[24]  D. Postma,et al.  Techniques in human airway inflammation: differences in plastic-embedded and snap-frozen sections for CD3, CD4, and CD8 immunostaining of bronchial biopsy specimens. , 1997, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[25]  J. Davies,et al.  Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells. , 1996, The Biochemical journal.

[26]  J E Cotes,et al.  Lung volumes and forced ventilatory flows , 1993, European Respiratory Journal.

[27]  J E Cotes,et al.  Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. , 1993, The European respiratory journal. Supplement.

[28]  W. Finkbeiner,et al.  Human tracheobronchial submucosal gland cells in culture. , 1990, American journal of respiratory cell and molecular biology.

[29]  D. Geddes.  Chronic airflow obstruction. , 1984, Postgraduate medical journal.

[30]  L. Reid.  Measurement of the Bronchial Mucous Gland Layer: A Diagnostic Yardstick in Chronic Bronchitis * , 1960, Thorax.