Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities.

[1]  David J. Barry,et al.  APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability. , 2017, Cancer discovery.

[2]  Miguel G. Blanco,et al.  A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis. , 2016, Developmental cell.

[3]  Y. Pommier,et al.  Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies. , 2016, Cancer research.

[4]  Peter J. Campbell,et al.  Chromothripsis and Kataegis Induced by Telomere Crisis , 2015, Cell.

[5]  Y. Liu,et al.  Replication stress activates DNA repair synthesis in mitosis , 2015, Nature.

[6]  Hanlee P. Ji,et al.  Pan-cancer analysis of the extent and consequences of intratumor heterogeneity , 2015, Nature Medicine.

[7]  T. Kruse,et al.  TopBP1 is required at mitosis to reduce transmission of DNA damage to G1 daughter cells , 2015, The Journal of cell biology.

[8]  Sergi Elizalde,et al.  Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution. , 2015, Cell reports.

[9]  P. Ellis,et al.  Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[10]  Matthew Meyerson,et al.  CHROMOTHRIPSIS FROM DNA DAMAGE IN MICRONUCLEI , 2015, Nature.

[11]  Anthony J. Cesare,et al.  Cell Death During Crisis Is Mediated by Mitotic Telomere Deprotection , 2015, Nature.

[12]  Ashley M. Laughney,et al.  Numerical chromosomal instability mediates susceptibility to radiation treatment , 2015, Nature Communications.

[13]  G. Calin,et al.  Targeting the microRNA-regulating DNA damage/repair pathways in cancer , 2014, Expert opinion on biological therapy.

[14]  J. Murnane,et al.  DNA-damage response during mitosis induces whole-chromosome missegregation. , 2014, Cancer discovery.

[15]  M. Berns,et al.  DNA Damage to a Single Chromosome End Delays Anaphase Onset* , 2014, The Journal of Biological Chemistry.

[16]  Linda Wordeman,et al.  Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells , 2014, Nature Cell Biology.

[17]  S. Bakhoum,et al.  Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy , 2014, Cancer.

[18]  G. Adelmant,et al.  Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks. , 2014, Molecular cell.

[19]  V. Giranda,et al.  Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer , 2014, Investigational New Drugs.

[20]  D. Durocher,et al.  Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions , 2014, Science.

[21]  K. Miyagawa,et al.  Targeting DNA damage response in cancer therapy , 2014, Cancer science.

[22]  R. Muschel,et al.  Targeting ATR in DNA damage response and cancer therapeutics. , 2014, Cancer treatment reviews.

[23]  Z. Shang,et al.  DNA-PKcs activates the Chk2–Brca1 pathway during mitosis to ensure chromosomal stability , 2014, Oncogenesis.

[24]  D. Compton,et al.  Cyclin A Regulates Kinetochore-Microtubules to Promote Faithful Chromosome Segregation , 2013, Nature.

[25]  Anthony J. Cesare,et al.  The telomere deprotection response is functionally distinct from the genomic DNA damage response. , 2013, Molecular cell.

[26]  Jiri Bartek,et al.  Replication stress links structural and numerical cancer chromosomal instability , 2013, Nature.

[27]  M. Varma,et al.  Physical and Chemical Mechanisms in Molecular Radiation Biology , 2012, Basic Life Sciences.

[28]  D. Compton,et al.  Kinetochores and disease: keeping microtubule dynamics in check! , 2012, Current opinion in cell biology.

[29]  J. Fitzpatrick,et al.  A Telomere Dependent DNA Damage Checkpoint Induced by Prolonged Mitotic Arrest , 2012, Nature Structural &Molecular Biology.

[30]  Neil J Ganem,et al.  DNA breaks and chromosome pulverization from errors in mitosis , 2012, Nature.

[31]  L. Symington,et al.  Double-strand break end resection and repair pathway choice. , 2011, Annual review of genetics.

[32]  R. Medema,et al.  Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations , 2011, Science.

[33]  Z. Szallasi,et al.  Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer , 2011, Cancer Epidemiology, Biomarkers & Prevention.

[34]  G. Terzoudi,et al.  Chromatin dynamics during cell cycle mediate conversion of DNA damage into chromatid breaks and affect formation of chromosomal aberrations: biological and clinical significance. , 2011, Mutation research.

[35]  Zoltan Szallasi,et al.  Paradoxical relationship between chromosomal instability and survival outcome in cancer. , 2011, Cancer research.

[36]  N. Carter,et al.  Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development , 2011, Cell.

[37]  Adria J. Sherman,et al.  Analysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation , 2010, Nucleic acids research.

[38]  G. Terzoudi,et al.  Functional cell-cycle chromatin conformation changes in the presence of DNA damage result into chromatid breaks: a new insight in the formation of radiation-induced chromosomal aberrations based on the direct observation of interphase chromatin. , 2010, Mutation research.

[39]  S. Jackson,et al.  DNA damage signaling in response to double-strand breaks during mitosis , 2010, The Journal of cell biology.

[40]  Duane A. Compton,et al.  Proliferation of aneuploid human cells is limited by a p53-dependent mechanism , 2010, The Journal of cell biology.

[41]  D. Compton,et al.  Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability , 2009, Current Biology.

[42]  R. Medema,et al.  Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells , 2009, Proceedings of the National Academy of Sciences.

[43]  Geert Verbeke,et al.  Chromosome instability is common in human cleavage-stage embryos , 2009, Nature Medicine.

[44]  P. Russell,et al.  Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair , 2008, Cell.

[45]  Samuel F. Bakhoum,et al.  Genome stability is ensured by temporal control of kinetochore-microtubule dynamics , 2008, Nature Cell Biology.

[46]  Stephen S. Taylor,et al.  Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery , 2008, Nature.

[47]  B. Weaver,et al.  Low Rates of Aneuploidy Promote Tumorigenesis while High Rates of Aneuploidy Cause Cell Death and Tumor Suppression , 2008, Cellular oncology : the official journal of the International Society for Cellular Oncology.

[48]  J. Yates,et al.  Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry , 2008, Science.

[49]  Alexey Khodjakov,et al.  Extra centrosomes and/or chromosomes prolong mitosis in human cells , 2008, Nature Cell Biology.

[50]  Takamitsu A Kato,et al.  Comparison of the induction and disappearance of DNA double strand breaks and gamma-H2AX foci after irradiation of chromosomes in G1-phase or in condensed metaphase cells. , 2008, Mutation research.

[51]  P. Jeggo,et al.  The impact of a negligent G2/M checkpoint on genomic instability and cancer induction , 2007, Nature Reviews Cancer.

[52]  P. Jeggo,et al.  Chromosome breakage after G2 checkpoint release , 2007, The Journal of cell biology.

[53]  鈴木 正敏.  Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation , 2006 .

[54]  Chen-Yang Shen,et al.  TTK/hMps1 Participates in the Regulation of DNA Damage Checkpoint Response by Phosphorylating CHK2 on Threonine 68* , 2005, Journal of Biological Chemistry.

[55]  D. Stern,et al.  Polo-like Kinase 1 and Chk2 Interact and Co-localize to Centrosomes and the Midbody* , 2003, The Journal of Biological Chemistry.

[56]  A. Mikhailov,et al.  DNA Damage during Mitosis in Human Cells Delays the Metaphase/Anaphase Transition via the Spindle-Assembly Checkpoint , 2002, Current Biology.

[57]  T. T. Su,et al.  DNA damage leads to a Cyclin A–dependent delay in metaphase-anaphase transition in the Drosophila gastrula , 2001, Current Biology.

[58]  R. Medema,et al.  Polo-like kinase-1 is a target of the DNA damage checkpoint , 2000, Nature Cell Biology.

[59]  Joel E. Tepper,et al.  Clinical Radiation Oncology , 2000 .

[60]  E. Rogakou,et al.  Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo , 1999, The Journal of cell biology.

[61]  W. K. Sinclair,et al.  X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. , 1966, Radiation research.

[62]  C. Hager,et al.  Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation. , 2007, Cancer research.

[63]  W. K. Sinclair.  Cyclic x-ray responses in mammalian cells in vitro. , 1968, Radiation research.