Bimodal Interventional Instrument Markers for Magnetic Particle Imaging and Magnetic Resonance Imaging—A Proof-of-Concept Study

The purpose of this work was to develop instrument markers that are visible in both magnetic particle imaging (MPI) and magnetic resonance imaging (MRI). The instrument markers were based on two different magnetic nanoparticle types (synthesized in-house KLB and commercial Bayoxide E8706). Coatings containing one of both particle types were fabricated and measured with a magnetic particle spectrometer (MPS) to estimate their MPI performance. Coatings based on both particle types were then applied on a segment of a nonmetallic guidewire. Imaging experiments were conducted using a commercial, preclinical MPI scanner and a preclinical 1 tesla MRI system. MPI image reconstruction was performed based on system matrices measured with dried KLB and Bayoxide E8706 coatings. The bimodal markers were clearly visible in both methods. They caused circular signal voids in MRI and areas of high signal intensity in MPI. Both the signal voids as well as the areas of high signal intensity were larger than the real marker size. Images that were reconstructed with a Bayoxide E8706 system matrix did not show sufficient MPI signal. Instrument markers with bimodal visibility are essential for the perspective of monitoring cardiovascular interventions with MPI/MRI hybrid systems.

[1]  E. Saritas,et al.  Simultaneous temperature and viscosity estimation capability via magnetic nanoparticle relaxation. , 2022, Medical physics.

[2]  T. Bley,et al.  Magnetic particle imaging for artifact-free imaging of intracranial flow diverter stents: A phantom study. , 2021, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[3]  T. Buzug,et al.  Magnetic Particle Imaging: In vitro Signal Analysis and Lumen Quantification of 21 Endovascular Stents , 2021, International journal of nanomedicine.

[4]  G. Greil,et al.  Interventional Cardiovascular Magnetic Resonance Imaging (iCMR) in an Adolescent with Pulmonary Hypertension , 2020, Medicina.

[5]  Jochen Franke,et al.  Hybrid MPI-MRI System for Dual-Modal In Situ Cardiovascular Assessments of Real-Time 3D Blood Flow Quantification—A Pre-Clinical In Vivo Feasibility Investigation , 2020, IEEE Transactions on Medical Imaging.

[6]  G. Adam,et al.  Visualization of spatial and temporal temperature distributions with magnetic particle imaging for liver tumor ablation therapy , 2020, Scientific Reports.

[7]  T. Buzug,et al.  Magnetic Particle Imaging: Artifact-Free Metallic Stent Lumen Imaging in a Phantom Study , 2019, Cardiovascular and interventional radiology.

[8]  V. Muthurangu,et al.  Cardiovascular magnetic resonance-guided right heart catheterization in a conventional CMR environment – predictors of procedure success and duration in pulmonary artery hypertension , 2019, Journal of Cardiovascular Magnetic Resonance.

[9]  T. Buzug,et al.  Magnetic Particle Imaging meets Computed Tomography: first simultaneous imaging , 2019, Scientific Reports.

[10]  T. Bley,et al.  Magnetic Particle Imaging–Guided Stenting , 2019, Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists.

[11]  T. Knopp,et al.  Human-sized magnetic particle imaging for brain applications , 2018, Nature Communications.

[12]  Thorsten M Buzug,et al.  First heating measurements of endovascular stents in magnetic particle imaging , 2018, Physics in medicine and biology.

[13]  C. Kuhl,et al.  White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 1: General Application White Paper: Interventionelle MRT: Status Quo und Entwicklungspotenzial unter ökonomischen Perspektiven, Teil 1: Generelle Anwendungen , 2017, RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren.

[14]  Jörn Borgert,et al.  Magnetic Particle Imaging (MPI): Experimental Quantification of Vascular Stenosis Using Stationary Stenosis Phantoms , 2017, PloS one.

[15]  T Knopp,et al.  Geometry planning and image registration in magnetic particle imaging using bimodal fiducial markers. , 2016, Medical physics.

[16]  Tobias Knopp,et al.  Magnetic Particle / Magnetic Resonance Imaging: In-Vitro MPI-Guided Real Time Catheter Tracking and 4D Angioplasty Using a Road Map and Blood Pool Tracer Approach , 2016, PloS one.

[17]  Jochen Franke,et al.  Magnetic Particle Imaging: A Resovist based Marking Technology for Guide Wires and Catheters for Vascular Interventions. , 2016, IEEE transactions on medical imaging.

[18]  Jochen Franke,et al.  System Characterization of a Highly Integrated Preclinical Hybrid MPI-MRI Scanner , 2016, IEEE Transactions on Medical Imaging.

[19]  Anthony Z. Faranesh,et al.  Segmented nitinol guidewires with stiffness-matched connectors for cardiovascular magnetic resonance catheterization: preserved mechanical performance and freedom from heating , 2015, Journal of Cardiovascular Magnetic Resonance.

[20]  Alexander Weber,et al.  Generic multi-purpose multi-modality phantom kit design , 2015, 2015 5th International Workshop on Magnetic Particle Imaging (IWMPI).

[21]  T Knopp,et al.  Joint reconstruction of non-overlapping magnetic particle imaging focus-field data , 2015, Physics in medicine and biology.

[22]  B Gleich,et al.  First experimental evidence of the feasibility of multi-color magnetic particle imaging , 2015, Physics in medicine and biology.

[23]  Patrick Vogel,et al.  MRI Meets MPI: A Bimodal MPI-MRI Tomograph , 2014, IEEE Transactions on Medical Imaging.

[24]  Gael Bringout,et al.  Safety measurements for heating of instruments for cardiovascular interventions in magnetic particle imaging (MPI) - first experiences. , 2014, Journal of healthcare engineering.

[25]  Jörg Barkhausen,et al.  Comparison of commercial iron oxide-based MRI contrast agents with synthesized high-performance MPI tracers , 2013, Biomedizinische Technik. Biomedical engineering.

[26]  Thorsten M Buzug,et al.  Toward cardiovascular interventions guided by magnetic particle imaging: First instrument characterization , 2013, Magnetic resonance in medicine.

[27]  Bernhard Gleich,et al.  Magnetic Particle imaging : Visualization of Instruments for Cardiovascular Intervention 1 , 2012 .

[28]  M. Knauth,et al.  Comparing different MR angiography strategies of carotid stents in a vascular flow model: toward stent-specific recommendations in MR follow-up , 2010, Neuroradiology.

[29]  B Gleich,et al.  Weighted iterative reconstruction for magnetic particle imaging , 2010, Physics in medicine and biology.

[30]  Thorsten M. Buzug,et al.  Magnetization response spectroscopy of superparamagnetic nanoparticles for magnetic particle imaging , 2009 .

[31]  Hyuk Yu,et al.  MR‐visible coatings for endovascular device visualization , 2006, Journal of magnetic resonance imaging : JMRI.

[32]  Bernhard Gleich,et al.  Tomographic imaging using the nonlinear response of magnetic particles , 2005, Nature.

[33]  T. Kampf,et al.  Magnetic Particle Imaging for Quantification of Vascular Stenoses: A Phantom Study , 2018, IEEE Transactions on Medical Imaging.

[34]  Eugen Hofmann,et al.  Visualization of vascular guidewires using MR tracking , 1998, Journal of magnetic resonance imaging : JMRI.