Functional and cytometric examination of different human lung epithelial cell types as drug transport barriers

[1]  M. V. Suresh,et al.  Pulmonary administration of a water-soluble curcumin complex reduces severity of acute lung injury. , 2012, American journal of respiratory cell and molecular biology.

[2]  Jiyun Yang,et al.  MicroRNA-126 Inhibits Tumor Cell Growth and Its Expression Level Correlates with Poor Survival in Non-Small Cell Lung Cancer Patients , 2012, PloS one.

[3]  D. Grainger,et al.  A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity. , 2012, Pharmacology & therapeutics.

[4]  Nan Zheng,et al.  A Cell-based Computational Modeling Approach for Developing Site-Directed Molecular Probes , 2012, PLoS Comput. Biol..

[5]  Ian Sayers,et al.  Evaluation of Differentiated Human Bronchial Epithelial Cell Culture Systems for Asthma Research , 2012, Journal of allergy.

[6]  Kelly Bérubé,et al.  Human primary bronchial lung cell constructs: the new respiratory models. , 2010, Toxicology.

[7]  T. Young,et al.  Increased mucociliary differentiation of human respiratory epithelial cells on hyaluronan-derivative membranes. , 2010, Acta biomaterialia.

[8]  Balázs Sarkadi,et al.  The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). , 2008, Drug discovery today.

[9]  D. Kell,et al.  Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? , 2008, Nature Reviews Drug Discovery.

[10]  Donna A Volpe,et al.  Variability in Caco-2 and MDCK cell-based intestinal permeability assays. , 2008, Journal of pharmaceutical sciences.

[11]  Min-Ki Lee,et al.  Air-liquid interface (ALI) culture of human bronchial epithelial cell monolayers as an in vitro model for airway drug transport studies. , 2007, Journal of pharmaceutical sciences.

[12]  L. Chin,et al.  A transformed human epithelial cell line that retains tight junctions post crisis , 1992, In Vitro Cellular & Developmental Biology - Animal.

[13]  J. Schiller,et al.  Establishment and characterization of a SV40 T-antigen immortalized human bronchial epithelial cell line , 1992, In Vitro Cellular & Developmental Biology - Animal.

[14]  Peter R. Byron,et al.  Inhaling medicines: delivering drugs to the body through the lungs , 2007, Nature Reviews Drug Discovery.

[15]  Ben Forbes,et al.  Culture of Calu-3 Cells at the Air Interface Provides a Representative Model of the Airway Epithelial Barrier , 2006, Pharmaceutical Research.

[16]  I. Gonda.  Systemic delivery of drugs to humans via inhalation. , 2006, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[17]  Pranav Shah,et al.  Role of Caco‐2 Cell Monolayers in Prediction of Intestinal Drug Absorption , 2006, Biotechnology progress.

[18]  Ben Forbes,et al.  Human respiratory epithelial cell culture for drug delivery applications. , 2005, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[19]  Y. Sugita‐Konishi,et al.  Effects of tributyltin on barrier functions in human intestinal Caco-2 cells. , 2004, Biochemical and biophysical research communications.

[20]  E. Frixione,et al.  Actin cytoskeleton role in the structural response of epithelial (MDCK) cells to low extracellular Ca2+ , 2004, Journal of Muscle Research & Cell Motility.

[21]  A. Szkotak,et al.  The role of the basolateral outwardly rectifying chloride channel in human airway epithelial anion secretion. , 2003, American journal of respiratory cell and molecular biology.

[22]  H. Junginger,et al.  Drug transport and metabolism characteristics of the human airway epithelial cell line Calu-3. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[23]  J. Widdicombe,et al.  Effects of media on differentiation of cultured human tracheal epithelium , 2003, In Vitro Cellular & Developmental Biology - Animal.

[24]  Keith E. Mostov,et al.  Building epithelial architecture: insights from three-dimensional culture models , 2002, Nature Reviews Molecular Cell Biology.

[25]  H. Junginger,et al.  Transport and local metabolism of budesonide and fluticasone propionate in a human bronchial epithelial cell line (Calu-3). , 2002, Journal of pharmaceutical sciences.

[26]  Christopher S. Chen,et al.  Engineering cellular microenvironments to improve cell-based drug testing. , 2002, Drug discovery today.

[27]  S. Frokjaer,et al.  Optimized conditions for MDCK permeability and turbidimetric solubility studies using compounds representative of BCS classes I-IV. , 2002, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[28]  R. Kinget,et al.  The lung as a route for systemic delivery of therapeutic proteins and peptides , 2001, Respiratory research.

[29]  A. Li,et al.  Screening for human ADME/Tox drug properties in drug discovery. , 2001, Drug discovery today.

[30]  J. Tolan,et al.  MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening. , 1999, Journal of pharmaceutical sciences.

[31]  G. Vunjak‐Novakovic,et al.  Culture of organized cell communities. , 1998, Advanced drug delivery reviews.

[32]  M. Chang,et al.  Growth and differentiation of conducting airway epithelial cells in culture. , 1997, The European respiratory journal.

[33]  J. Yoon,et al.  Quantitation of mucin RNA by PCR reveals induction of both MUC2 and MUC5AC mRNA levels by retinoids. , 1996, The American journal of physiology.

[34]  L. Abdullah,et al.  Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells. , 1996, American journal of respiratory cell and molecular biology.

[35]  J. Widdicombe,et al.  Culture and transformation of human airway epithelial cells. , 1995, The American journal of physiology.

[36]  J. Wine,et al.  Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion. , 1994, The American journal of physiology.

[37]  J. Schiller,et al.  Phenotypic, molecular and genetic-characterization of transformed human bronchial epithelial-cell strains. , 1994, International journal of oncology.

[38]  H. Hauri,et al.  The differentiating intestinal epithelial cell: establishment and maintenance of functions through interactions between cellular structures. , 1992, Annual review of cell biology.