Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
暂无分享,去创建一个
Mark E. Davis | D. Seligson | J. Zuckerman | C. H. J. Choi | A. Tolcher | C. Alabi | Y. Yen | J. Heidel | A. Ribas
[1] D. Mason,et al. Transferrin receptors in human tissues: their distribution and possible clinical relevance. , 1983, Journal of clinical pathology.
[2] J. Wright,et al. Elevated expression of M1 and M2 components and drug-induced posttranscriptional modulation of ribonucleotide reductase in a hydroxyurea-resistant mouse cell line. , 1987, Biochemistry.
[3] A. Fire,et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.
[4] T. Tuschl,et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.
[5] David L. Lewis,et al. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice , 2002, Nature Genetics.
[6] Judy Lieberman,et al. RNA interference targeting Fas protects mice from fulminant hepatitis , 2003, Nature Medicine.
[7] M. Schartl,et al. Comparative studies on the ultrastructure of malignant melanoma in fish and human by freeze-etching and transmission electron microscopy , 2004, Journal of Cancer Research and Clinical Oncology.
[8] Matthias John,et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs , 2004, Nature.
[9] Nuno M F S A Cerqueira,et al. Overview of ribonucleotide reductase inhibitors: an appealing target in anti-tumour therapy. , 2005, Current medicinal chemistry.
[10] Mark E. Davis,et al. Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging , 2006, Nucleic acids research.
[11] M. Manoharan,et al. RNAi therapeutics: a potential new class of pharmaceutical drugs , 2006, Nature chemical biology.
[12] Y. Yen,et al. Analysis of ribonucleotide reductase M2 mRNA levels in patient samples after GTI-2040 antisense drug treatment. , 2006, Oncology reports.
[13] A. Elmaagacli,et al. Therapeutic application of small interfering RNA directed against bcr-abl transcripts to a patient with imatinib-resistant chronic myeloid leukaemia , 2007, Clinical and Experimental Medicine.
[14] Mark E. Davis,et al. Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA , 2007, Proceedings of the National Academy of Sciences.
[15] Wolfgang A. Weber,et al. Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging , 2007, Proceedings of the National Academy of Sciences.
[16] Mark E. Davis,et al. Potent siRNA Inhibitors of Ribonucleotide Reductase Subunit RRM2 Reduce Cell Proliferation In vitro and In vivo , 2007, Clinical Cancer Research.
[17] Justine R. Smith,et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 , 2008, Nature.
[18] S. Elbashir,et al. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). , 2008, Antiviral research.
[19] Mark E. Davis,et al. Impact of tumor‐specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA‐containing nanoparticles , 2008, Biotechnology and bioengineering.
[20] Mark E. Davis. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. , 2009, Molecular pharmaceutics.
[21] Mark E. Davis,et al. Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements , 2009, Proceedings of the National Academy of Sciences.
[22] Svetlana Shulga Morskaya,et al. RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy , 2009, Antimicrobial Agents and Chemotherapy.
[23] John J. Rossi,et al. The promises and pitfalls of RNA-interference-based therapeutics , 2009, Nature.
[24] R. Hickerson,et al. First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder. , 2010, Molecular therapy : the journal of the American Society of Gene Therapy.