US elastography of breast and prostate lesions.

Elastography is a technique that maps relative tissue stiffness. Ultrasonographic (US) elastography (sonoelastography) is a novel modality that is the subject of active research for clinical applications, primarily breast and prostate lesion imaging. Breast and prostate tumors generally have biomechanical properties different from those of normal tissues: Tumors are usually stiffer. This phenomenon is responsible for tissue contrast on elastograms. For the prostate gland and breast, the main image acquisition techniques are vibration sonoelastography and compression sonoelastography. The sonoelastographic appearances of several common breast lesions, including fibroadenomas, simple and complex cysts, ductal carcinomas, malignant lymph nodes, and hematomas, are reviewed. In addition, the US elastographic appearances of the normal prostate gland, prostate carcinomas, and benign prostate hyperplasia are illustrated. Potential pitfalls in the interpretation of elastograms, including false-positive and false-negative images, are illustrated. These imaging findings are derived from ongoing research because sonoelastography is not yet accepted for routine clinical use.

[1]  Kenneth Hoyt,et al.  Real-time shear velocity imaging using sonoelastographic techniques. , 2007, Ultrasound in medicine & biology.

[2]  H. Hricak,et al.  Imaging of prostate cancer. , 2007, Radiologic clinics of North America.

[3]  M. Fink,et al.  Supersonic shear imaging: a new technique for soft tissue elasticity mapping , 2004, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[4]  T. Schlomm,et al.  Evaluation of prostate cancer detection with ultrasound real-time elastography: a comparison with step section pathological analysis after radical prostatectomy. , 2008, European urology.

[5]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[6]  K. Parker,et al.  Sono-Elasticity: Medical Elasticity Images Derived from Ultrasound Signals in Mechanically Vibrated Targets , 1988 .

[7]  Min Jung Kim,et al.  Power Doppler sonography: evaluation of solid breast lesions and correlation with lymph node metastasis. , 2008, Clinical imaging.

[8]  Devang J. Doshi,et al.  Complex cystic breast masses: diagnostic approach and imaging-pathologic correlation. , 2007, Radiographics : a review publication of the Radiological Society of North America, Inc.

[9]  F. S. Vinson,et al.  A pulsed Doppler ultrasonic system for making noninvasive measurements of the mechanical properties of soft tissue. , 1987, Journal of rehabilitation research and development.

[10]  J. Radolf,et al.  Bull’s eye: Unraveling the medical mystery of Lyme disease , 2004 .

[11]  A. Martegani,et al.  Elastosonography in the diagnosis of the nodular breast lesions: preliminary report. , 2005, La Radiologia medica.

[12]  Michael F. Insana,et al.  Viscoelastic Imaging of Breast Tumor Microenvironment With Ultrasound , 2004, Journal of Mammary Gland Biology and Neoplasia.

[13]  M. O’Donnell,et al.  Diagnosing Cysts With Correlation Coefficient Images From 2‐Dimensional Freehand Elastography , 2007, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[14]  J F Greenleaf,et al.  Vibro-acoustography imaging of permanent prostate brachytherapy seeds in an excised human prostate--preliminary results and technical feasibility. , 2009, Ultrasonics.

[15]  G. Bartsch,et al.  Comparison of sonoelastography guided biopsy with systematic biopsy: impact on prostate cancer detection , 2007, European Radiology.

[16]  W. Berg,et al.  Cystic lesions of the breast: sonographic-pathologic correlation. , 2003, Radiology.

[17]  B. Garra,et al.  Elastography of breast lesions: initial clinical results. , 1997, Radiology.

[18]  J. Ophir,et al.  Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues , 1991, Ultrasonic imaging.

[19]  E E Konofagou,et al.  Quo vadis elasticity imaging? , 2004, Ultrasonics.

[20]  Y. Mizutani,et al.  The utility of transrectal real-time elastography in the diagnosis of prostate cancer. , 2008, Ultrasound in medicine & biology.

[21]  K. Parker,et al.  "Sonoelasticity" images derived from ultrasound signals in mechanically vibrated tissues. , 1990, Ultrasound in medicine & biology.

[22]  G. Bartsch,et al.  Sonoelastography of the prostate: comparison with systematic biopsy findings in 492 patients. , 2008, European journal of radiology.

[23]  N. Wasserman Benign prostatic hyperplasia: a review and ultrasound classification. , 2006, Radiologic clinics of North America.

[24]  E. Messing,et al.  Quantitative characterization of viscoelastic properties of human prostate correlated with histology. , 2008, Ultrasound in medicine & biology.