Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening.
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Mark Stidham | Mark Hilgers | John Finn | M. Hilgers | J. Finn | Kedar G C | M. Stidham | K. G C
[1] O. Nureki,et al. Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features. , 1999, Journal of molecular biology.
[2] J. Risler,et al. How methionyl-tRNA synthetase creates its amino acid recognition pocket upon L-methionine binding. , 2001, Journal of molecular biology.
[3] Sunghoon Kim,et al. Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors. , 2006, Bioorganic & medicinal chemistry letters.
[4] A. Pope,et al. A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology. , 2000, Analytical biochemistry.
[5] A. K. Forrest,et al. Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. , 2002, Journal of medicinal chemistry.
[6] P. Youngman,et al. Antimicrobials: new solutions badly needed. , 2002, Current opinion in microbiology.
[7] C. Venkatachalam,et al. LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites. , 2003, Journal of molecular graphics & modelling.
[8] John Finn,et al. The identification of quality antibacterial drug discovery targets: a case study with aminoacyl-tRNA synthetases , 2000 .
[9] J. Risler,et al. Crystallographic study at 2.5 A resolution of the interaction of methionyl-tRNA synthetase from Escherichia coli with ATP. , 1990, Journal of molecular biology.
[10] Roberta B Carey,et al. Invasive methicillin-resistant Staphylococcus aureus infections in the United States. , 2007, JAMA.
[11] Osman Güner,et al. Pharmacophore modeling and three dimensional database searching for drug design using catalyst: recent advances. , 2004, Current medicinal chemistry.
[12] P. Gallant,et al. Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors. , 2003, Bioorganic & medicinal chemistry letters.
[13] Robert E. W. Hancock,et al. The end of an era? , 2007, Nature Reviews Drug Discovery.