Obesity inhibits the osteogenic differentiation of human adipose-derived stem cells

[1]  J. Gimble,et al.  Human Adipose Stromal/Stem Cells from Obese Donors Show Reduced Efficacy in Halting Disease Progression in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis , 2016, Stem cells.

[2]  J. Gimble,et al.  Analysis of the Pro- and Anti-Inflammatory Cytokines Secreted by Adult Stem Cells during Differentiation , 2015, Stem cells international.

[3]  B. Lecka-Czernik,et al.  High bone mass in adult mice with diet-induced obesity results from a combination of initial increase in bone mass followed by attenuation in bone formation; implications for high bone mass and decreased bone quality in obesity , 2015, Molecular and Cellular Endocrinology.

[4]  R. Llull,et al.  Adipose tissue and stem/progenitor cells: discovery and development. , 2015, Clinics in plastic surgery.

[5]  R. Borojevic,et al.  Obesity and weight loss could alter the properties of adipose stem cells? , 2015, World journal of stem cells.

[6]  J. Gimble,et al.  Photoactivated miR-148b-nanoparticle conjugates improve closure of critical size mouse calvarial defects. , 2015, Acta biomaterialia.

[7]  V. Tkachuk,et al.  Disturbed angiogenic activity of adipose-derived stromal cells obtained from patients with coronary artery disease and diabetes mellitus type 2 , 2014, Journal of Translational Medicine.

[8]  E. Jo,et al.  Effects of Obesity on Bone Mass and Quality in Ovariectomized Female Zucker Rats , 2014, Journal of obesity.

[9]  J. Rubin,et al.  Adipose-derived stem cells: Implications in tissue regeneration. , 2014, World journal of stem cells.

[10]  Cecilia Romagnoli,et al.  Adipose mesenchymal stem cells in the field of bone tissue engineering. , 2014, World journal of stem cells.

[11]  G. Balian,et al.  A novel strategy of spine defect repair with a degradable bioactive scaffold preloaded with adipose-derived stromal cells. , 2014, The spine journal : official journal of the North American Spine Society.

[12]  Markus Rautiainen,et al.  Adipose Stem Cells Used to Reconstruct 13 Cases With Cranio‐Maxillofacial Hard‐Tissue Defects , 2014, Stem cells translational medicine.

[13]  D. Harris,et al.  Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation , 2014, Journal of Translational Medicine.

[14]  S. Both,et al.  Concise Review: Cell‐Based Strategies in Bone Tissue Engineering and Regenerative Medicine , 2014, Stem cells translational medicine.

[15]  V. Tkachuk,et al.  Tissue-Specific Progenitor and Stem Cells Adipose-Derived Mesenchymal Stromal Cells From Aged Patients With Coronary Artery Disease Keep Mesenchymal Stromal Cell Properties but Exhibit Characteristics of Aging and Have Impaired Angiogenic Potential , 2013 .

[16]  M. Barba,et al.  Adipose-Derived Mesenchymal Cells for Bone Regereneration: State of the Art , 2013, BioMed research international.

[17]  J. Gimble,et al.  Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways , 2013, Breast Cancer Research.

[18]  L. Gottlieb,et al.  Autologous Immediate Cranioplasty with Vascularized Bone in High-Risk Composite Cranial Defects , 2013, Plastic and reconstructive surgery.

[19]  J. Pons-Kühnemann,et al.  Reconstruction of critical-size mandibular defects in immunoincompetent rats with human adipose-derived stromal cells. , 2013, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

[20]  K. Sinha,et al.  Genetic and molecular control of osterix in skeletal formation , 2013, Journal of cellular biochemistry.

[21]  G. Sàndor,et al.  Adipose stem cell tissue-engineered construct used to treat large anterior mandibular defect: a case report and review of the clinical application of good manufacturing practice-level adipose stem cells for bone regeneration. , 2013, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[22]  A. Allori,et al.  Characterization of adipose-derived mesenchymal stem cell combinations for vascularized bone engineering. , 2013, Tissue engineering. Part A.

[23]  P. Zuk.  Adipose-Derived Stem Cells in Tissue Regeneration: A Review , 2013 .

[24]  A. Galinier,et al.  Aging-related Decrease of Human ASC Angiogenic Potential Is Reversed by Hypoxia Preconditioning Through ROS Production. , 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

[25]  J. Gimble,et al.  Obesity‐Associated Dysregulation of Calpastatin and MMP‐15 in Adipose‐Derived Stromal Cells Results in their Enhanced Invasion , 2012, Stem cells.

[26]  G. Vilahur,et al.  The subcutaneous adipose tissue reservoir of functionally active stem cells is reduced in obese patients , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  Xin Peng,et al.  What Is the Price to Pay for a Free Fibula Flap? A Systematic Review of Donor-Site Morbidity following Free Fibula Flap Surgery , 2012, Plastic and reconstructive surgery.

[28]  Jay J Cao.  Effects of obesity on bone metabolism , 2011, Journal of orthopaedic surgery and research.

[29]  J. Gimble,et al.  Yield and characterization of subcutaneous human adipose-derived stem cells by flow cytometric and adipogenic mRNA analyzes. , 2010, Cytotherapy.

[30]  Ralph Müller,et al.  Guidelines for assessment of bone microstructure in rodents using micro–computed tomography , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  Benjamin M. Wu,et al.  Human Adipose Derived Stromal Cells Heal Critical Size Mouse Calvarial Defects , 2010, PloS one.

[32]  Li Sun,et al.  Diet‐induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice , 2010, Annals of the New York Academy of Sciences.

[33]  Masaaki,et al.  Local transplantation of human multipotent adipose-derived stem cells accelerates fracture healing via enhanced osteogenesis and angiogenesis , 2010, Laboratory Investigation.

[34]  G. Steinberg,et al.  Adipose tissue as an endocrine organ , 2010, Molecular and Cellular Endocrinology.

[35]  R. Yu,et al.  Osteoclastogenesis by bone marrow-derived macrophages is enhanced in obese mice. , 2009, The Journal of nutrition.

[36]  L. Levin,et al.  Management of Postneurosurgical Bone Flap Loss Caused by Infection , 2008, Plastic and reconstructive surgery.

[37]  Rüdiger Weiner,et al.  Angiogenesis in bone fracture healing: a bioregulatory model. , 2008, Journal of theoretical biology.

[38]  Yilin Cao,et al.  Repair of cranial bone defects with adipose derived stem cells and coral scaffold in a canine model. , 2007, Biomaterials.

[39]  Paolo Giannoni,et al.  A tissue engineering approach to bone repair in large animal models and in clinical practice. , 2007, Biomaterials.

[40]  G. Evans,et al.  In vivo osteogenic potential of human adipose-derived stem cells/poly lactide-co-glycolic acid constructs for bone regeneration in a rat critical-sized calvarial defect model. , 2007, Tissue engineering.

[41]  J. Rubin,et al.  The Osteogenic Potential of Adipose-Derived Stem Cells for the Repair of Rabbit Calvarial Defects , 2006, Annals of plastic surgery.

[42]  A. Greenberg,et al.  Obesity and the role of adipose tissue in inflammation and metabolism. , 2006, The American journal of clinical nutrition.

[43]  Ayse B. Celil,et al.  BMP-2 and Insulin-like Growth Factor-I Mediate Osterix (Osx) Expression in Human Mesenchymal Stem Cells via the MAPK and Protein Kinase D Signaling Pathways* , 2005, Journal of Biological Chemistry.

[44]  Marc Hedrick,et al.  Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. , 2005, Tissue engineering.

[45]  R. LaPrade,et al.  Donor-site morbidity after osteochondral autograft transfer procedures. , 2004, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[46]  Christopher H Contag,et al.  Adipose-derived adult stromal cells heal critical-size mouse calvarial defects , 2004, Nature Biotechnology.

[47]  Keith L. March,et al.  Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells , 2004, Circulation.

[48]  Hyo-Sang Park,et al.  BMP-2-induced Osterix expression is mediated by Dlx5 but is independent of Runx2. , 2003, Biochemical and biophysical research communications.

[49]  K. Nakashima,et al.  Transcriptional mechanisms in osteoblast differentiation and bone formation. , 2003, Trends in genetics : TIG.

[50]  G. Sándor.  Tissue engineering of bone: Clinical observations with adipose-derived stem cells, resorbable scaffolds, and growth factors , 2012, Annals of maxillofacial surgery.

[51]  E. Arrigoni,et al.  Human adipose-derived stem cells isolated from young and elderly women: their differentiation potential and scaffold interaction during in vitro osteoblastic differentiation. , 2009, Cytotherapy.

[52]  S. Cartmell,et al.  Genes and proteins involved in the regulation of osteogenesis , 2007 .

[53]  Theodore Miclau,et al.  Assessing angiogenesis during fracture healing. , 2006, The Iowa orthopaedic journal.