Use of In Vitro and In Vivo Data in the Design, Development, and Quality Control of Sustained‐Release Decongestant Dosage Forms

Study Objectives. To investigate the use of in vitro and in vivo data in the development of a sustained‐release, carbomer‐based dosage form (Entex LA tablets); and to compare the in vitro dissolution of pseudoephedrine from a sustained‐release, hydroxypropylcellulose‐based dosage form (Entex PSE tablets) and four branded competitors with different sustained‐release matrixes.