Gentamicin in the neonatal period.

The clinical pharmacology of gentamicin was studied in 42 newborn infants. Gentamicin was found to be effective in vitro against most gram negative organisms encountered in neonatal infections; 1.5 mg/kg/dose every 8 to 12 hours in neonates produced mean peak serum levels of 2.5 to 5.0μg/ml. Serum antibacterial activity persisted for 8 to 12 hours. The serum gentamicin half-life was longer in premature than full-term infants during the first week of life only; beyond this time, the half-lives were similar and approached that reported in adults. No evidence of accumulation was observed after multiple doses. A limited trial of gentamicin in the treatment of severe neonatal infections demonstrated the drug to be effective. Acute toxicity was not observed. Specific recommendations and precautions are outlined for treating selected neonates with gentamicin.

[1]  H. Shirkey.  Therapeutic orphans 1970. , 1970, The Journal of infectious diseases.

[2]  D. Armstrong,et al.  Gentamicin in the treatment of pulmonary infections. , 1969, The Journal of infectious diseases.

[3]  H. D. Riley,et al.  Gentamicin: clinical and laboratory studies in infants and children. , 1969, The Journal of infectious diseases.

[4]  R. Holt,et al.  Gentamicin in infections of the central nervous system. , 1969, The Journal of infectious diseases.

[5]  C. Cox.  Gentamicin, a new aminoglycoside antibiotic: clinical and laboratory studies in urinary tract infection. , 1969, The Journal of infectious diseases.

[6]  C. M. Martin,et al.  Gram-negative rod bacteremia. , 1969, The Journal of infectious diseases.

[7]  J. Wersäll,et al.  Ototoxicity of gentamicin. , 1969, The Journal of infectious diseases.

[8]  P. Wehrle,et al.  Gentamicin in the treatment of meningitis in neonates. , 1969, The Journal of infectious diseases.

[9]  D. Smith.  R factors for aminoglycoside antibiotics. , 1969, The Journal of infectious diseases.

[10]  J. Calnan,et al.  The dose, distribution, and excretion of gentamicin with speical reference to renal failure. , 1969, The Journal of infectious diseases.

[11]  B. Macmillan.  Gentamicin in the management of thermal injuries. , 1969, The Journal of infectious diseases.

[12]  S. G. Axline,et al.  CLINICAL PHARMACOLOGY OF KANAMYCIN IN PREMATURE INFANTS * , 1966, Annals of the New York Academy of Sciences.

[13]  H. Eichenwald.  SOME OBSERVATIONS ON DOSAGE AND TOXICITY OF KANAMYCIN IN PREMATURE AND FULL‐TERM INFANTS * , 1966, Annals of the New York Academy of Sciences.

[14]  M. Finland,et al.  GENTAMICIN: ACTIVITY in Vitro AND OBSERVATIONS IN 26 PATIENTS , 1964, The American journal of the medical sciences.

[15]  E. Steers,et al.  An inocula replicating apparatus for routine testing of bacterial susceptibility to antibiotics. , 1959, Antibiotics & chemotherapy.

[16]  A. J. Schaffer.  Diseases of the Newborn , 1938 .

[17]  B. Calesnick,et al.  PHARMACOLOGY OF GENTAMICIN, A NEW BROAD-SPECTRUM ANTIBIOTIC. , 1963, Antimicrobial agents and chemotherapy.

[18]  W. A. Randall,et al.  Assay methods of antibiotics , 1955 .