Intracellular pathways following uptake of bevacizumab in RPE cells.

[1]  J. Roider,et al.  Effects of aflibercept on primary RPE cells: toxicity, wound healing, uptake and phagocytosis , 2014, British Journal of Ophthalmology.

[2]  S. Fuchs,et al.  Fucoidan Reduces Secretion and Expression of Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium and Reduces Angiogenesis In Vitro , 2014, PloS one.

[3]  U. Schraermeyer,et al.  Different effects of intravitreally injected ranibizumab and aflibercept on retinal and choroidal tissues of monkey eyes , 2014, British Journal of Ophthalmology.

[4]  K. Kaarniranta,et al.  Bevacizumab does not affect autophagy clearance during proteasomal inhibition in human retinal pigment epithelial cells , 2014 .

[5]  A. Klettner VEGF-A and its inhibitors in age-related macular degeneration - pharmacokinetic differences and their retinal and systemic implications , 2014 .

[6]  T. Krohne,et al.  Pharmakokinetik intravitreal applizierter VEGF-Inhibitoren , 2014, Der Ophthalmologe.

[7]  O. Janssen,et al.  Shedding of endogenous MHC class I‐related chain molecules A and B from different human tumor entities: Heterogeneous involvement of the “a disintegrin and metalloproteases” 10 and 17 , 2013, International journal of cancer.

[8]  L. Liotta,et al.  Retinal pigment epithelium (RPE) exosomes contain signaling phosphoproteins affected by oxidative stress. , 2013, Experimental cell research.

[9]  Allison L. Zajac,et al.  Local Cytoskeletal and Organelle Interactions Impact Molecular-Motor-Driven Early Endosomal Trafficking , 2013, Current Biology.

[10]  P. Low,et al.  Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma , 2013, Nature Communications.

[11]  Graça Raposo,et al.  Extracellular vesicles: Exosomes, microvesicles, and friends , 2013, The Journal of cell biology.

[12]  J. Roider,et al.  Regulation of constitutive vascular endothelial growth factor secretion in retinal pigment epithelium/choroid organ cultures: p38, nuclear factor kappaB, and the vascular endothelial growth factor receptor-2/phosphatidylinositol 3 kinase pathway , 2013, Molecular vision.

[13]  Usha Chakravarthy,et al.  Ranibizumab versus bevacizumab to treat neovascular age-related macular degeneration: one-year findings from the IVAN randomized trial. , 2012, Ophthalmology.

[14]  G. Lang,et al.  Actions of bevacizumab and ranibizumab on microvascular retinal endothelial cells: similarities and differences , 2012, British Journal of Ophthalmology.

[15]  P. Campochiaro Anti-Vascular Endothelial Growth Factor Treatment for Retinal Vein Occlusions , 2012, Ophthalmologica.

[16]  G. Lang Diabetic Macular Edema , 2012, Ophthalmologica.

[17]  Bernd Giebel,et al.  Exosomes: small vesicles participating in intercellular communication. , 2012, The international journal of biochemistry & cell biology.

[18]  S. Bhat,et al.  Secretion of αB-Crystallin via exosomes: New clues to the function of human retinal pigment epithelium , 2011, Communicative & integrative biology.

[19]  C. Théry Exosomes: secreted vesicles and intercellular communications , 2011, F1000 biology reports.

[20]  Glenn J Jaffe,et al.  Ranibizumab and bevacizumab for neovascular age-related macular degeneration. , 2011, The New England journal of medicine.

[21]  M. Record,et al.  Exosomes as intercellular signalosomes and pharmacological effectors. , 2011, Biochemical pharmacology.

[22]  C. Regillo,et al.  Preferred therapies for neovascular age-related macular degeneration , 2011, Current opinion in ophthalmology.

[23]  K. Steel,et al.  The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65 , 2011, Human molecular genetics.

[24]  R. Kuijpers,et al.  The neonatal Fc receptor is expressed by human retinal pigment epithelial cells and is downregulated by tumour necrosis factor-alpha , 2011, British Journal of Ophthalmology.

[25]  Yonghong Sun,et al.  Expression and distribution of immunoglobulin G and its receptors in an immune privileged site: the eye , 2011, Cellular and Molecular Life Sciences.

[26]  E. Barrón,et al.  αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells , 2010, PloS one.

[27]  J. Roider,et al.  VEGF antagonists decrease barrier function of retinal pigment epithelium in vitro: possible participation of intracellular glutathione. , 2010, Investigative ophthalmology & visual science.

[28]  J. Roider,et al.  Intracellular bevacizumab reduces phagocytotic uptake in RPE cells , 2010, Graefe's Archive for Clinical and Experimental Ophthalmology.

[29]  J. Skepper,et al.  Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. , 2010, Cancer research.

[30]  J. Roider,et al.  Treating age-related macular degeneration - interaction of VEGF-antagonists with their target. , 2009, Mini reviews in medicinal chemistry.

[31]  T. Meyer,et al.  Different properties of VEGF-antagonists: Bevacizumab but not Ranibizumab accumulates in RPE cells , 2009, Graefe's Archive for Clinical and Experimental Ophthalmology.

[32]  M. Tso,et al.  Autophagy, exosomes and drusen formation in age-related macular degeneration , 2009, Autophagy.

[33]  J. Roider,et al.  Triamcinolone acetonide prevents oxidative stress-induced tight junction disruption of retinal pigment epithelial cells , 2009, Graefe's Archive for Clinical and Experimental Ophthalmology.

[34]  J. Roider,et al.  Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: efficiency and possible additional pathways. , 2008, Investigative ophthalmology & visual science.

[35]  P. Heiduschka,et al.  Penetration of bevacizumab through the retina after intravitreal injection in the monkey. , 2007, Investigative ophthalmology & visual science.

[36]  C. Futter The molecular regulation of organelle transport in mammalian retinal pigment epithelial cells. , 2006, Pigment cell research.

[37]  T. Hasson,et al.  The unconventional myosin-VIIa associates with lysosomes. , 2005, Cell motility and the cytoskeleton.

[38]  Olaf Strauss,et al.  The retinal pigment epithelium in visual function. , 2005, Physiological reviews.

[39]  David S. Williams,et al.  Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[40]  S. Grinstein,et al.  Differential Role of Actin, Clathrin, and Dynamin in Fcγ Receptor-mediated Endocytosis and Phagocytosis* , 2003, The Journal of Biological Chemistry.

[41]  François Darchen,et al.  MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes , 2002, EMBO reports.

[42]  G. Hoppe,et al.  Oxidized low density lipoprotein-induced inhibition of processing of photoreceptor outer segments by RPE. , 2001, Investigative ophthalmology & visual science.

[43]  P. Woodman Biogenesis of the Sorting Endosome: The Role of Rab5 , 2000, Traffic.

[44]  B. Deurs,et al.  Rab7: a key to lysosome biogenesis. , 2000, Molecular biology of the cell.

[45]  S. Schmid,et al.  Actin Assembly Plays a Variable, but not Obligatory Role in Receptor‐Mediated Endocytosis , 2000, Traffic.

[46]  Erika S Wittchen,et al.  Protein Interactions at the Tight Junction , 1999, The Journal of Biological Chemistry.

[47]  H. Geuze,et al.  Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes* , 1998, The Journal of Biological Chemistry.

[48]  A. Wandinger-Ness,et al.  Rab 7: an important regulator of late endocytic membrane traffic , 1995, The Journal of cell biology.

[49]  D. Sabatini,et al.  Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells , 1993, The Journal of cell biology.

[50]  Kai Simons,et al.  The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway , 1992, Cell.

[51]  B. Matsumoto,et al.  Cytoskeletal redifferentiation of feline, monkey, and human RPE cells in culture. , 1990, Investigative ophthalmology & visual science.

[52]  P. Gouras,et al.  Proteins from human retinal pigment epithelial cells: evidence that a major protein is actin. , 1983, Investigative ophthalmology & visual science.

[53]  M. Hall,et al.  The distribution of actin in cultured normal and dystrophic rat pigment epithelial cells during the phagocytosis of rod outer segments. , 1983, Investigative ophthalmology & visual science.