论文信息 - Robustness Tests of a Model Based Predictive Control Strategy for Depth of Anesthesia Regulation in a Propofol to Bispectral Index Framework

Robustness Tests of a Model Based Predictive Control Strategy for Depth of Anesthesia Regulation in a Propofol to Bispectral Index Framework

This paper verifies the robustness of a model based predictive control scheme for depth of anesthesia (DOA) regulation. The manipulated variable is Propofol, which is used in a Model based Predictive Control (MPC) algorithm for automatic induction and control of DOA. In turn, DOA is evaluated by means of the Bispectral index (BIS). The simulation tests are performed on a set of 17 virtually generated realistic patients with significantly varying sensitivity to Propofol infusion. The results show a high-efficiency, optimal dosage and robustness of the MPC algorithm to induce and maintain the desired BIS reference while rejecting typical disturbances from surgery.

[1] Gade Pandu Rangaiah,et al. Advanced Control Strategies for the Regulation of Hypnosis with Propofol , 2009 .

[2] Wassim M. Haddad,et al. Nonlinear adaptive control for intensive care unit sedation and operating room hypnosis , 2003, Proceedings of the 2003 American Control Conference, 2003..

[3] Hugo Vereecke,et al. Ability of the Bispectral Index, Autoregressive Modelling with Exogenous Input-derived Auditory Evoked Potentials, and Predicted Propofol Concentrations to Measure Patient Responsiveness during Anesthesia with Propofol and Remifentanil , 2003, Anesthesiology.

[4] S. Shafer,et al. The Influence of Method of Administration and Covariates on the Pharmacokinetics of Propofol in Adult Volunteers , 1998, Anesthesiology.

[5] Michel M R F Struys,et al. Performance Evaluation of Two Published Closed-loop Control Systems Using Bispectral Index Monitoring: A Simulation Study , 2004, Anesthesiology.

[6] S L Shafer,et al. The influence of age on propofol pharmacodynamics. , 1999, Anesthesiology.