The influence of maternal factors on the concentration of vitamin A in mature breast milk.

BACKGROUND & AIMS This study evaluated the relationship between vitamin A concentration in maternal milk and the characteristics of the donors of a Brazilian human milk bank. MATERIAL AND METHODS A total of 136 donors were selected in 2003-2004 for micronutrient determinations in breast milk and blood, anthropometric measurements and investigation of obstetric, socioeconomic-demographic factors, and life style. Maternal serum/milk samples were obtained for vitamin A, iron, copper, and zinc determinations. Vitamin A concentrations in breast milk and blood were assessed by high-performance liquid chromatography. Copper, zinc and iron concentrations in breast milk, and copper and zinc concentrations in blood were detected by atomic emission spectrophotometry. Serum ceruloplasmin and serum iron were determined, respectively, by nephelometry and colorimetry. A linear regression model assessed the associations between milk concentrations of vitamin A and maternal factors. RESULTS Vitamin A in milk presented positive associations with iron in milk (p<0.001), serum retinol (p=0.03), maternal work (p=0.02), maternal age (p=0.02), and oral contraceptive use (p=0.01), and a negative association with % body fat (p=0.01) (R(2)=0.47). CONCLUSION These results suggest that some nutritional, obstetric, and socioeconomic-demographic factors may have an effect on mature breast milk concentrations of vitamin A in apparently healthy Brazilian mothers.

[1]  B. Brabin,et al.  Serum and breast-milk vitamin A in women during lactation in rural Chiang Mai, Thailand , 2002, Annals of tropical paediatrics.

[2]  J. Arnaud,et al.  Simultaneous determination of retinol, α-tocopherol and β-carotene in serum by isocratic high-performance liquid chromatography , 1991 .

[3]  C. Donangelo,et al.  Nutrient composition of banked human milk in Brazil and influence of processing on zinc distribution in milk fractions. , 2002, Nutrition.

[4]  T. Greiner,et al.  Evidence of grave vitamin A deficiency among lactating women in the semi-arid rural area of Makhaza in Zimbabwe. A population-based study , 2001, European Journal of Clinical Nutrition.

[5]  C. West,et al.  Concurrent micronutrient deficiencies in lactating mothers and their infants in Indonesia 1 – 3 , 2022 .

[6]  W. Schultink,et al.  Moderate zinc and vitamin A deficiency in breast milk of mothers from East-Jakarta , 1998, European Journal of Clinical Nutrition.

[7]  K. Westerterp,et al.  Assessment of Body Composition and Breast Milk Volume in Lactating Mothers in Pastoral Communities in Pokot, Kenya, Using Deuterium Oxide , 2005, Annals of Nutrition and Metabolism.

[8]  M. Gershwin,et al.  Studies of marginal zinc deprivation in rhesus monkeys. III. Effects on vitamin A metabolism. , 1984, The American journal of clinical nutrition.

[9]  Nutrition Board,et al.  RECOMMENDED DIETARY ALLOWANCES. , 1964, Clinical pediatrics.

[10]  J. Durnin,et al.  Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 Years , 1974, British Journal of Nutrition.

[11]  L. Filer,et al.  Present Knowledge in Nutrition , 1996 .

[12]  D. Thurnham,et al.  Optimal nutrition: vitamin A and the carotenoids , 1999, Proceedings of the Nutrition Society.

[13]  J. Olson,et al.  A brief guide to current methods of assessing vitamin A status , 1993 .

[14]  S. Kelleher,et al.  Molecular regulation of milk trace mineral homeostasis. , 2005, Molecular aspects of medicine.

[15]  C. Saunders,et al.  Hipovitaminose A no Brasil: um problema de saúde pública , 2002 .

[16]  N. Trugo,et al.  Retinol, carotenoids, and tocopherols in the milk of lactating adolescents and relationships with plasma concentrations. , 2008, Nutrition.

[17]  Stoltzfus Rj,et al.  Breast-Milk Vitamin A as an Indicator of the Vitamin A Status of Women and Infants , 1995 .

[18]  A. R. Frisancho.  Anthropometric Standards for the Assessment of Growth and Nutritional Status , 1990 .

[19]  S. Kelleher,et al.  Iron Metabolism in Infants and Children , 2007, Food and nutrition bulletin.

[20]  P. Rondó,et al.  Influence of iron on vitamin A nutritional status. , 2008, Nutrition reviews.

[21]  Timothy G. Lohman,et al.  Advances in Body Composition Assessment , 1992 .

[22]  M. Morgano,et al.  COMPOSIÇÃO MINERAL DO LEITE MATERNO DE BANCOS DE LEITE 1 , 2005 .

[23]  J. Dórea,et al.  Quality Control of Banked Milk in Brasília, Brazil , 2006, Journal of human lactation : official journal of International Lactation Consultant Association.

[24]  A. Tungtrongchitr,et al.  The relationships between anthropometric measurements, serum vitamin A and E concentrations and lipid profiles in overweight and obese subjects. , 2003, Asia Pacific journal of clinical nutrition.