Matrix modeling and remodeling: A biological interplay regulating tissue homeostasis and diseases.

The overall structure and architecture of the extracellular matrix undergo dramatic alterations in composition, form, and functionality over time. The stochasticity begins during development, essential for maintaining organismal homeostasis and is heavily implicated in many pathobiological states including fibrosis and cancer. Modeling and remodeling of the matrix is driven by the local cellular milieu and secreted and cell-associated components in a framework of dynamic reciprocity. This collection of expertly-written reviews aims to relay state-of-the-art information concerning the mechanisms of matrix modeling and remodeling in physiological development and disease.

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[59]  J. Quigley,et al.  Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature. , 2015, Matrix biology : journal of the International Society for Matrix Biology.

[60]  G. Opdenakker,et al.  Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis , 2006, The Journal of experimental medicine.

[61]  W. Parks,et al.  Matrix remodeling by MMPs during wound repair. , 2015, Matrix biology : journal of the International Society for Matrix Biology.

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[65]  A. Pozzi,et al.  The nature and biology of basement membranes. , 2017, Matrix biology : journal of the International Society for Matrix Biology.

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[67]  T. Haverty,et al.  Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. , 1992, Kidney international.

[68]  Byung‐Hyun Cha,et al.  Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration. , 2016, Osteoarthritis and cartilage.

[69]  A. Theocharis,et al.  In vitro reconstitution of complexes between pro‐matrix metalloproteinase‐9 and the proteoglycans serglycin and versican , 2013, The FEBS journal.

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[71]  Z. Werb,et al.  Matrix metalloproteinases in stem cell regulation and cancer , 2015, Matrix biology : journal of the International Society for Matrix Biology.

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[83]  M. Foster.  Basement membranes and autoimmune diseases. , 2017, Matrix biology : journal of the International Society for Matrix Biology.

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[85]  T. Pihlajaniemi,et al.  Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients. , 2017, Matrix biology : journal of the International Society for Matrix Biology.

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[91]  A. Chandra,et al.  Biomarkers for wound healing and their evaluation. , 2016, Journal of wound care.

[92]  K. J. Grande-Allen,et al.  Decorin-transforming Growth Factor-β Interaction Regulates Matrix Organization and Mechanical Characteristics of Three-dimensional Collagen Matrices* , 2007, Journal of Biological Chemistry.

[93]  R. Iozzo,et al.  Proteoglycans regulate autophagy via outside-in signaling: an emerging new concept. , 2015, Matrix biology : journal of the International Society for Matrix Biology.

[94]  F. Maquart,et al.  Lumican inhibits angiogenesis by interfering with α2β1 receptor activity and downregulating MMP-14 expression. , 2011, Thrombosis research.

[95]  C. Stuelten,et al.  Extracellular Matrix Proteoglycans Control the Fate of Bone Marrow Stromal Cells* , 2005, Journal of Biological Chemistry.

[96]  G. Brayer,et al.  Structural basis of collagen fiber degradation by cathepsin K , 2014, Proceedings of the National Academy of Sciences.

[97]  S. Apte,et al.  ADAMTS proteins as modulators of microfibril formation and function. , 2015, Matrix biology : journal of the International Society for Matrix Biology.

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[99]  Y. Itoh.  Membrane-type matrix metalloproteinases: Their functions and regulations. , 2015, Matrix biology : journal of the International Society for Matrix Biology.

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[103]  R. Iozzo,et al.  Endorepellin-evoked Autophagy Contributes to Angiostasis * , 2016, The Journal of Biological Chemistry.

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[107]  A. Wells,et al.  Skin tissue repair: Matrix microenvironmental influences. , 2016, Matrix biology : journal of the International Society for Matrix Biology.

[108]  Marcin J. Skwark,et al.  Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis. , 2017, Matrix biology : journal of the International Society for Matrix Biology.

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[121]  A. Theocharis,et al.  EMMPRIN/CD147-encriched membrane vesicles released from malignant human testicular germ cells increase MMP production through tumor-stroma interaction. , 2014, Biochimica et biophysica acta.

[122]  R. Iozzo,et al.  A current view of perlecan in physiology and pathology: A mosaic of functions. , 2017, Matrix biology : journal of the International Society for Matrix Biology.

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[134]  A. Pshezhetsky,et al.  Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis* , 2008, Journal of Biological Chemistry.

[135]  Judith Campisi,et al.  Senescent cells as a source of inflammatory factors for tumor progression , 2010, Cancer and Metastasis Reviews.

[136]  R. Iozzo,et al.  Decorin: a guardian from the matrix. , 2012, The American journal of pathology.

[137]  R. Iozzo,et al.  Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy , 2017, The Journal of Biological Chemistry.