Functional assessment of Broca's area using near infrared spectroscopy in humans.

We used near-infrared spectroscopy (NIRS) to compare functional hemoglobin concentration changes (delta[oxy-Hb] and delta[deoxy-Hb]) over human language and motor cortices. Eight subjects performed finger opposition, tongue movement, and covert visual object naming in an interleaved block paradigm design. NIRS revealed paradigm specific patterns of delta[oxy-Hb] and delta[deoxy-Hb] providing cortical localization of each function. During each task, significant response overlap was observed when comparing the [oxy-Hb] signals, whereas delta[deoxy-Hb] seemed more localized. Furthermore, by applying magnitude and time to significance measures to the delta[deoxy-Hb] response profile, Broca's area was easily distinguished from neighboring tongue (and hand) motor representation. Delta[oxy-Hb] did not provide this level of specificity. These findings suggest delta[deoxy-Hb] as the preferential NIRS parameter to map language cortices.

[1]  A. Villringer,et al.  Beyond the Visible—Imaging the Human Brain with Light , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[2]  Marco Ferrari,et al.  Lateral frontal cortex oxygenation changes during translation and language switching revealed by non-invasive near-infrared multi-point measurements , 2002, Brain Research Bulletin.

[3]  David A. Boas,et al.  A Quantitative Comparison of Simultaneous BOLD fMRI and NIRS Recordings during Functional Brain Activation , 2002, NeuroImage.

[4]  Frithjof Kruggel,et al.  Near‐infrared spectroscopy can detect brain activity during a color–word matching Stroop task in an event‐related design , 2002, Human brain mapping.

[5]  Koichi Mori,et al.  Assessing cerebral representations of short and long vowel categories by NIRS , 2002, Neuroreport.

[6]  Nader Pouratian,et al.  Spatial/temporal correlation of BOLD and optical intrinsic signals in humans , 2002, Magnetic resonance in medicine.

[7]  M. Weinand,et al.  Temporal lobe seizure interhemispheric propagation time depends on nonepileptic cortical cerebral blood flow , 2001, Epilepsy Research.

[8]  Arthur W. Toga,et al.  Temporal and Topographical Characterization of Language Cortices Using Intraoperative Optical Intrinsic Signals , 2000, NeuroImage.

[9]  A Villringer,et al.  Near-infrared spectroscopy: does it function in functional activation studies of the adult brain? , 2000, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[10]  K. Sakai,et al.  Temporal cortex activation during speech recognition: an optical topography study , 1999, Cognition.

[11]  Per Lav Madsen,et al.  Near-infrared oximetry of the brain , 1999, Progress in Neurobiology.

[12]  C. N. Guy,et al.  fMRI and EEG Responses to Periodic Visual Stimulation , 1999, NeuroImage.

[13]  A. Villringer,et al.  Noninvasive Assessment of Changes in Cytochrome-c Oxidase Oxidation in Human Subjects during Visual Stimulation , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[14]  Atsushi Maki,et al.  Non-invasive assessment of language dominance with near-infrared spectroscopic mapping , 1998, Neuroscience Letters.

[15]  K. Sakatani,et al.  Language-activated cerebral blood oxygenation and hemodynamic changes of the left prefrontal cortex in poststroke aphasic patients: a near-infrared spectroscopy study. , 1998, Stroke.

[16]  A. Fallgatter,et al.  Prefrontal Hypooxygenation during Language Processing Assessed with Near-Infrared Spectroscopy , 1998, Neuropsychobiology.

[17]  A. Villringer,et al.  Non-invasive optical spectroscopy and imaging of human brain function , 1997, Trends in Neurosciences.

[18]  A. Villringer,et al.  Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS) — correlation with simultaneous rCBF-PET measurements , 1997, Brain Research.

[19]  Yoko Hoshi,et al.  Near-Infrared Optical Detection of Sequential Brain Activation in the Prefrontal Cortex during Mental Tasks , 1997, NeuroImage.

[20]  J. Mayhew,et al.  Cerebral Vasomotion: A 0.1-Hz Oscillation in Reflected Light Imaging of Neural Activity , 1996, NeuroImage.

[21]  A. Kleinschmidt,et al.  Simultaneous Recording of Cerebral Blood Oxygenation Changes during Human Brain Activation by Magnetic Resonance Imaging and Near-Infrared Spectroscopy , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  H. Flor,et al.  Non-invasive functional mapping of the human motor cortex using near-infrared spectroscopy. , 1996, Neuroreport.

[23]  D. Delpy,et al.  Measurement of Cranial Optical Path Length as a Function of Age Using Phase Resolved Near Infrared Spectroscopy , 1994 .

[24]  D. Delpy,et al.  The effect of overlying tissue on the spatial sensitivity profile of near-infrared spectroscopy. , 1995, Physics in medicine and biology.