Renaming the DSCR1 / Adapt78 gene family as RCAN: regulators of calcineurin

Kelvin J. A. Davies,* Gennady Ermak,* Beverley A. Rothermel, Melanie Pritchard, Joseph Heitman, Joohong Ahnn, Flavio Henrique-Silva, Dana Crawford, Silvia Canaider,** Pierluigi Strippoli,** Paolo Carinci,** Kyung-Tai Min, Deborah S. Fox, Kyle W. Cunningham, Rhonda Bassel-Duby, Eric N. Olson, Zhuohua Zhang, R. Sanders Williams, Hans-Peter Gerber,*** Merce Perez-Riba, Hisao Seo, Xia Cao, Claude B. Klee, Juan Miguel Redondo, Lois J. Maltais, Elspeth A. Bruford, Sue Povey, Jeffery D. Molkentin,**** Frank D. McKeon, Elia J. Duh, Gerald R. Crabtree,§§§§ Martha S. Cyert, Susana de la Luna, and Xavier Estivill

[1]  K. Davies,et al.  RCAN1‐1L is overexpressed in neurons of Alzheimer's disease patients , 2007, The FEBS journal.

[2]  M. Pérez-Riba,et al.  RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression. , 2007, Biochimica et biophysica acta.

[3]  M. Mulero,et al.  Functional characterization of the calcipressin 1 motif that suppresses calcineurin-mediated NFAT-dependent cytokine gene expression in human T cells. , 2006, Cellular signalling.

[4]  Xin Gao,et al.  NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21 , 2006, Nature.

[5]  L. Vitale,et al.  Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3). , 2006, Gene.

[6]  P. Pfluger,et al.  Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[7]  K. Davies,et al.  RCAN1 (DSCR1 or Adapt78) * stimulates expression of GSK‐3β , 2006, The FEBS journal.

[8]  B. Su,et al.  Protein Kinase-mediated Regulation of Calcineurin through the Phosphorylation of Modulatory Calcineurin-interacting Protein 1* , 2006, Journal of Biological Chemistry.

[9]  K. Davies,et al.  Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product Calcipressin 1 (or RCAN1) in disease , 2005, Cellular and Molecular Life Sciences CMLS.

[10]  F. McKeon,et al.  Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Calcineurin-Binding Protein Cbp1 Directs the Specificity of Calcineurin-Dependent Hyphal Elongation during Mating in Cryptococcus neoformans , 2005, Eukaryotic Cell.

[12]  J. Redondo,et al.  Depolarization of Neural Cells Induces Transcription of the Down Syndrome Critical Region 1 Isoform 4 via a Calcineurin/Nuclear Factor of Activated T Cells-dependent Pathway* , 2005, Journal of Biological Chemistry.

[13]  J. Neilson,et al.  Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. , 2005, Developmental cell.

[14]  C. Cook,et al.  Expression of calcipressin1, an inhibitor of the phosphatase calcineurin, is altered with aging and Alzheimer's disease. , 2005, Journal of Alzheimer's disease : JAD.

[15]  H. Seo,et al.  Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. , 2005, Molecular endocrinology.

[16]  T. Aigaki,et al.  Expression Level of sarah, a Homolog of DSCR1, Is Critical for Ovulation and Female Courtship Behavior in Drosophila melanogaster , 2004, Genetics.

[17]  Takahide Kohro,et al.  Vascular Endothelial Growth Factor- and Thrombin-induced Termination Factor, Down Syndrome Critical Region-1, Attenuates Endothelial Cell Proliferation and Angiogenesis*♦ , 2004, Journal of Biological Chemistry.

[18]  T. Miyashita,et al.  Identification of novel direct transcriptional targets of glucocorticoid receptor , 2004, Leukemia.

[19]  Napoleone Ferrara,et al.  Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. , 2004, Blood.

[20]  K. Becker,et al.  DSCR1(Adapl78) modulates expression of SOD1 , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  Andre Levchenko,et al.  GSK-3 kinases enhance calcineurin signaling by phosphorylation of RCNs. , 2004, Genes & development.

[22]  K. Min,et al.  The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: Implications for mental retardation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Lin Chen,et al.  Transcriptional regulation by calcium, calcineurin, and NFAT. , 2003, Genes & development.

[24]  X. Estivill,et al.  Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life. , 2003, The Biochemical journal.

[25]  K. Davies,et al.  Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein. , 2003, Free radical biology & medicine.

[26]  F. McKeon,et al.  The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin , 2003, Nature Immunology.

[27]  D. H. Kim,et al.  The Caenorhabditis elegans homologue of Down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin. , 2003, Journal of molecular biology.

[28]  Rick B. Vega,et al.  Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  K. Davies,et al.  DSCR1(Adapt78)‐‐A Janus Gene Providing Stress Protection but Causing Alzheimer's Disease? , 2003, IUBMB life.

[30]  Rick B. Vega,et al.  The role of modulatory calcineurin-interacting proteins in calcineurin signaling. , 2003, Trends in cardiovascular medicine.

[31]  H. Seo,et al.  Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. , 2002, The Biochemical journal.

[32]  Rick B. Vega,et al.  Multiple Domains of MCIP1 Contribute to Inhibition of Calcineurin Activity* , 2002, The Journal of Biological Chemistry.

[33]  K. Davies,et al.  The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium‐mediated stress damage, including transient oxidative stress , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  T. Morgan,et al.  Chronic Overexpression of the Calcineurin Inhibitory Gene DSCR1 (Adapt78) Is Associated with Alzheimer's Disease* , 2001, The Journal of Biological Chemistry.

[35]  Rick B. Vega,et al.  Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[36]  X. Estivill,et al.  Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesis , 2001, Mechanisms of Development.

[37]  E. Olson,et al.  Independent Signals Control Expression of the Calcineurin Inhibitory Proteins MCIP1 and MCIP2 in Striated Muscles , 2000, Circulation research.

[38]  P. Strippoli,et al.  The murine DSCR1-like (Down syndrome candidate region 1) gene family: conserved synteny with the human orthologous genes. , 2000, Gene.

[39]  J. Heitman,et al.  Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans , 2000, The EMBO journal.

[40]  D. Crawford,et al.  adapt78 protects cells against stress damage and suppresses cell growth. , 2000, Archives of biochemistry and biophysics.

[41]  K. Cunningham,et al.  A conserved family of calcineurin regulators. , 2000, Genes & development.

[42]  X. Estivill,et al.  DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. , 2000, Human molecular genetics.

[43]  Rick B. Vega,et al.  A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin Signaling* , 2000, The Journal of Biological Chemistry.

[44]  P. Strippoli,et al.  A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). , 2000, Genomics.

[45]  X. Estivill,et al.  Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. , 1997, Genomics.

[46]  K. Davies,et al.  Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress. , 1997, Archives of biochemistry and biophysics.

[47]  H. Seo,et al.  Molecular Cloning of a Novel Thyroid Hormone-responsive Gene, ZAKI-4, in Human Skin Fibroblasts* , 1996, The Journal of Biological Chemistry.

[48]  D. Söll,et al.  A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis. , 1996, The EMBO journal.

[49]  X. Estivill,et al.  A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart. , 1995, Human molecular genetics.

[50]  C. Disteche,et al.  Down syndrome phenotypes: the consequences of chromosomal imbalance. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. Delabar,et al.  Mapping of the Down syndrome phenotype on chromosome 21 at the molecular level. , 1994, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.