Adaptive homeostasis and the free radical theory of ageing

[1]  W. O. Fenn,et al.  Oxygen poisoning and x-irradiation: a mechanism in common. , 1954, Science.

[2]  D. Harman.  Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.

[3]  L. Hayflick.  THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. , 1965, Experimental cell research.

[4]  B Chance,et al.  The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. , 1973, The Biochemical journal.

[5]  B. Poole.  Diffusion effects in the metabolism of hydrogen peroxide by rat liver peroxisomes. , 1975, Journal of theoretical biology.

[6]  L. Pauling,et al.  Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[7]  E. Foerster,et al.  Peroxisomal fatty acid oxidation as detected by H2O2 production in intact perfused rat liver. , 1981, The Biochemical journal.

[8]  A. Goldberg,et al.  The product of the lon (capR) gene in Escherichia coli is the ATP-dependent protease, protease La. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[9]  A. Goldberg,et al.  Protease La, the lon gene product, cleaves specific fluorogenic peptides in an ATP-dependent reaction. , 1985, The Journal of biological chemistry.

[10]  A. Goldberg,et al.  Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La. , 1988, The Journal of biological chemistry.

[11]  G. Storz,et al.  OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Kleinschmidt,et al.  Proteinase yscE, the yeast proteasome/multicatalytic‐multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival. , 1991, The EMBO journal.

[13]  K. Davies,et al.  Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. , 1991, Gerontology.

[14]  R. S. Sohal,et al.  Relationship between catalase activity, life span and some parameters associated with antioxidant defenses in Drosophila melanogaster , 1992, Mechanisms of Ageing and Development.

[15]  M. Willingham,et al.  A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[16]  G. Schatz,et al.  Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration. , 1994, Science.

[17]  F. Sherman,et al.  PIM1 encodes a mitochondrial ATP-dependent protease that is required for mitochondrial function in the yeast Saccharomyces cerevisiae. , 1994, The Journal of biological chemistry.

[18]  T. Reinheckel,et al.  Proteolysis in Cultured Liver Epithelial Cells during Oxidative Stress , 1995, The Journal of Biological Chemistry.

[19]  J. M. Davies,et al.  Transient adaptation to oxidative stress in yeast. , 1995, Archives of biochemistry and biophysics.

[20]  K. Davies,et al.  Transient adaptation of oxidative stress in mammalian cells. , 1995, Archives of biochemistry and biophysics.

[21]  B. Demple,et al.  Redox signaling and gene control in the Escherichia coli soxRS oxidative stress regulon--a review. , 1996, Gene.

[22]  J S Valentine,et al.  Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae , 1996, The Journal of Biological Chemistry.

[23]  T. Reinheckel,et al.  Degradation of Oxidized Proteins in K562 Human Hematopoietic Cells by Proteasome* , 1996, The Journal of Biological Chemistry.

[24]  C. Epstein,et al.  Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. , 1997, Archives of biochemistry and biophysics.

[25]  T. Reinheckel,et al.  Degradation of oxidized proteins in mammalian cells , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[26]  B. Ames,et al.  The free radical theory of aging matures. , 1998, Physiological reviews.

[27]  A. Elia,et al.  Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons , 1998, Nature Genetics.

[28]  J. Tower,et al.  FLP Recombinase-Mediated Induction of Cu/Zn-Superoxide Dismutase Transgene Expression Can Extend the Life Span of Adult Drosophila melanogaster Flies , 1999, Molecular and Cellular Biology.

[29]  K. Davies.  The Broad Spectrum of Responses to Oxidants in Proliferating Cells: A New Paradigm for Oxidative Stress , 1999, IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology.

[30]  B. Friguet,et al.  Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[31]  K. Davies,et al.  Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[32]  K. Davies,et al.  Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[33]  T. Reinheckel,et al.  Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress. , 2000, Archives of biochemistry and biophysics.

[34]  K. Davies,et al.  Mitochondrial free radical generation, oxidative stress, and aging. , 2000, Free radical biology & medicine.

[35]  B. Friguet,et al.  Age-related alterations of proteasome structure and function in aging epidermis , 2000, Experimental Gerontology.

[36]  C. Franceschi,et al.  Fibroblast cultures from healthy centenarians have an active proteasome , 2000, Experimental Gerontology.

[37]  K. Davies,et al.  Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I— effects of proliferative senescence , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[38]  S. Melov,et al.  Extension of life-span with superoxide dismutase/catalase mimetics. , 2000, Science.

[39]  C J Epstein,et al.  Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[40]  T. Grune,et al.  Proteolysis of oxidised proteins and cellular senescence , 2000, Experimental Gerontology.

[41]  J. Holstege,et al.  Human Cu/Zn Superoxide Dismutase (SOD1) Overexpression in Mice Causes Mitochondrial Vacuolization, Axonal Degeneration, and Premature Motoneuron Death and Accelerates Motoneuron Disease in Mice Expressing a Familial Amyotrophic Lateral Sclerosis Mutant SOD1 , 2000, Neurobiology of Disease.

[42]  V. Longo,et al.  Regulation of Longevity and Stress Resistance by Sch9 in Yeast , 2001, Science.

[43]  E. Stadtman,et al.  Oxidative modification of proteins during aging , 2001, Experimental Gerontology.

[44]  K. Davies,et al.  Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells , 2001, Cellular and Molecular Life Sciences CMLS.

[45]  K. Davies.  Degradation of oxidized proteins by the 20S proteasome. , 2001, Biochimie.

[46]  B. Friguet,et al.  Age-dependent declines in proteasome activity in the heart. , 2002, Archives of biochemistry and biophysics.

[47]  M. Tohyama,et al.  Transmission of cell stress from endoplasmic reticulum to mitochondria , 2002, The Journal of cell biology.

[48]  K. Davies,et al.  Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism , 2002, Nature Cell Biology.

[49]  A. Hilliker,et al.  RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[50]  J. Tower,et al.  Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. , 2002, Genetics.

[51]  T. Aigaki,et al.  Longevity determination genes in Drosophila melanogaster , 2002, Mechanisms of Ageing and Development.

[52]  P. Elsner,et al.  Photoaging is associated with protein oxidation in human skin in vivo. , 2002, The Journal of investigative dermatology.

[53]  K. Davies,et al.  Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress , 2002, FEBS letters.

[54]  T. Mariani,et al.  Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. , 2002, Free radical biology & medicine.

[55]  T. Reinheckel,et al.  Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[56]  Gary Ruvkun,et al.  A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity , 2003, Nature Genetics.

[57]  K. Davies,et al.  Ubiquitin Conjugation Is Not Required for the Degradation of Oxidized Proteins by Proteasome* , 2003, The Journal of Biological Chemistry.

[58]  C. Link,et al.  A stress-responsive glutathione S-transferase confers resistance to oxidative stress in Caenorhabditis elegans. , 2003, Free Radical Biology & Medicine.

[59]  J. D. Engel,et al.  Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation , 2003, Nature Genetics.

[60]  PRODUCTION , 2003 .

[61]  C. Warren Olanow,et al.  Altered Proteasomal Function in Sporadic Parkinson's Disease , 2003, Experimental Neurology.

[62]  K. Davies,et al.  The proteasomal system and HNE-modified proteins. , 2003, Molecular aspects of medicine.

[63]  Martin Holzenberger,et al.  IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice , 2003, Nature.

[64]  T. Blackwell,et al.  SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. , 2003, Genes & development.

[65]  A. Paul,et al.  A Sod2 null mutation confers severely reduced adult life span in Drosophila. , 2003, Genetics.

[66]  P. Piper,et al.  Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells. , 2003, Free radical biology & medicine.

[67]  J. Bismuth,et al.  Changes in rat liver mitochondria with aging , 2003 .

[68]  Jason G. Belter,et al.  The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults. , 2003, Free radical biology & medicine.

[69]  P. Karplus,et al.  Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling , 2003, Science.

[70]  Bertrand Friguet,et al.  Impact of ageing on proteasome structure and function in human lymphocytes. , 2003, The international journal of biochemistry & cell biology.

[71]  C. Epstein,et al.  Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. , 2003, Physiological genomics.

[72]  K. Davies,et al.  Selective degradation of oxidatively modified protein substrates by the proteasome. , 2003, Biochemical and biophysical research communications.

[73]  A. Diaspro,et al.  SOD2 functions downstream of Sch9 to extend longevity in yeast. , 2003, Genetics.

[74]  S. Rattan.  Aging intervention, prevention, and therapy through hormesis. , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.

[75]  A. Folsom,et al.  Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes? , 2004, The American journal of clinical nutrition.

[76]  M. Brand,et al.  Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[77]  O. Isacson,et al.  Generalized brain and skin proteasome inhibition in Huntington's disease , 2004, Annals of neurology.

[78]  C. Epstein,et al.  Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. , 2004, Free radical biology & medicine.

[79]  K. Davies,et al.  Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. , 2004, The international journal of biochemistry & cell biology.

[80]  D. Epstein,et al.  Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. , 2004, Biochemical and biophysical research communications.

[81]  Kiheung Kim,et al.  Ko Kuei Chen: a pioneer of modern pharmacological research in China , 2022, Protein & cell.

[82]  Anil K. Jaiswal,et al.  Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants* , 2005, Journal of Biological Chemistry.

[83]  M. Emond,et al.  Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria , 2005, Science.

[84]  Kunihiro Matsumoto,et al.  Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[85]  K. Davies,et al.  Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. , 2005, Free radical biology & medicine.

[86]  Ken Itoh,et al.  Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species‐induced cell injury , 2005, FEBS letters.

[87]  Chao Cheng,et al.  Sir2 Blocks Extreme Life-Span Extension , 2005, Cell.

[88]  E. Niki,et al.  Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage , 2005, Neuroscience Letters.

[89]  Roberto Pastor-Barriuso,et al.  Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality , 2005, Annals of Internal Medicine.

[90]  Sharda P. Singh,et al.  Lifespan extension in hypomorphic daf‐2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2‐2 , 2005, Aging cell.

[91]  Siegfried Hekimi,et al.  Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. , 2005, Genes & development.

[92]  L. Partridge,et al.  Dietary restriction in Drosophila , 2005, Mechanisms of Ageing and Development.

[93]  Vera Adam-Vizi,et al.  Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. , 2005, Antioxidants & redox signaling.

[94]  D. Harman.  Free Radical Theory of Aging: An Update , 2006, Annals of the New York Academy of Sciences.

[95]  G. Lithgow,et al.  Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments , 2006, Biogerontology.

[96]  Rochelle Buffenstein,et al.  High oxidative damage levels in the longest‐living rodent, the naked mole‐rat , 2006, Aging cell.

[97]  J. Vijg,et al.  Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase. , 2006, Antioxidants & redox signaling.

[98]  L. Guarente,et al.  Two neurons mediate diet-restriction-induced longevity in C. elegans , 2007, Nature.

[99]  S. Tavaré,et al.  Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes , 2007, Genome Biology.

[100]  G. Semenza,et al.  HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells , 2007, Cell.

[101]  C. Kenyon,et al.  Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex , 2007, Proceedings of the National Academy of Sciences.

[102]  J. Vanfleteren,et al.  Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans , 2007, Experimental Gerontology.

[103]  J. Miquel,et al.  Theories of ageing , 2007, IUBMB life.

[104]  Jae Sung Hwang,et al.  Age-associated decrease in proteasome content and activities in human dermal fibroblasts: restoration of normal level of proteasome subunits reduces aging markers in fibroblasts from elderly persons. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[105]  Arlan Richardson,et al.  Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[106]  Sten Orrenius,et al.  Mitochondria, oxidative stress and cell death , 2007, Apoptosis.

[107]  K. Davies,et al.  Production, detection, and adaptive responses to free radicals in exercise. , 2008, Free radical biology & medicine.

[108]  Joy W. Chang,et al.  Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction , 2008, Proceedings of the National Academy of Sciences.

[109]  David Gems,et al.  Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. , 2008, Genes & development.

[110]  Wei Zhao,et al.  Alterations of activity and intracellular distribution of the 20S proteasome in ageing retinal pigment epithelial cells , 2008, Experimental Gerontology.

[111]  Linda Partridge,et al.  Minireview Stress-response Hormesis and Aging: ''that Which Does Not Kill Us Makes Us Stronger'' Figure 1. Dose-response Curve of a Treatment with a Hormetic Effect Minireview Cell Metabolism , 2022 .

[112]  S. Hekimi,et al.  Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans , 2009, PLoS genetics.

[113]  K. Davies,et al.  Mitochondrial Lon protease is a human stress protein. , 2009, Free radical biology & medicine.

[114]  Jaehyoung Cho,et al.  Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain , 2009, Current Biology.

[115]  Yan Li,et al.  Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[116]  R. Levine,et al.  Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[117]  A. Hilliker,et al.  Hypoxia rescues early mortality conferred by superoxide dismutase deficiency. , 2009, Free radical biology & medicine.

[118]  N. Breusing,et al.  Inverse correlation of protein oxidation and proteasome activity in liver and lung , 2009, Mechanisms of Ageing and Development.

[119]  C. Epstein,et al.  The overexpression of major antioxidant enzymes does not extend the lifespan of mice , 2008, Aging cell.

[120]  C. Winterbourn,et al.  Mitochondrial peroxiredoxin involvement in antioxidant defence and redox signalling. , 2010, The Biochemical journal.

[121]  Tobias Jung,et al.  Age-related differences in oxidative protein-damage in young and senescent fibroblasts. , 2009, Archives of biochemistry and biophysics.

[122]  P. Treuting,et al.  Lifespan extension in genetically modified mice , 2009, Aging cell.

[123]  J. Keller,et al.  Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver , 2009, Mechanisms of Ageing and Development.

[124]  I. Martin,et al.  Sod2 knockdown in the musculature has whole-organism consequences in Drosophila. , 2009, Free radical biology & medicine.

[125]  T. Siddique,et al.  Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. , 2009, Human molecular genetics.

[126]  A. Bokov,et al.  Is the oxidative stress theory of aging dead? , 2009, Biochimica et biophysica acta.

[127]  C. Epstein,et al.  Overexpression of Mn superoxide dismutase does not increase life span in mice. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[128]  W. Burhans,et al.  Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity , 2010, Proceedings of the National Academy of Sciences.

[129]  Siegfried Hekimi,et al.  A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans , 2010, PLoS biology.

[130]  Y. Kim,et al.  Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber , 2010, The EMBO journal.

[131]  H. Forman,et al.  C‐Myc is a Nrf2‐interacting protein that negatively regulates phase II genes through their electrophile responsive elements , 2010, IUBMB life.

[132]  K. Davies,et al.  THE IMMUNOPROTEASOME, THE 20S PROTEASOME, AND THE PA28αβ PROTEASOME REGULATOR ARE OXIDATIVE STRESS‐ADAPTIVE PROTEOLYTIC COMPLEXES , 2010, The Biochemical journal.

[133]  Yuichi Matsushima,et al.  Mitochondrial Lon protease regulates mitochondrial DNA copy number and transcription by selective degradation of mitochondrial transcription factor A (TFAM) , 2010, Proceedings of the National Academy of Sciences.

[134]  Linda Partridge,et al.  Extending Healthy Life Span—From Yeast to Humans , 2010, Science.

[135]  Lan Huang,et al.  Regulation of the 26S Proteasome Complex During Oxidative Stress , 2010, Science Signaling.

[136]  P. Kloetzel,et al.  Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress , 2010, Cell.

[137]  J. Kordower,et al.  Ageing as a primary risk factor for Parkinson's disease: evidence from studies of non-human primates , 2011, Nature Reviews Neuroscience.

[138]  M. Ristow,et al.  Extending life span by increasing oxidative stress. , 2011, Free Radical Biology & Medicine.

[139]  L. C. Pomatto,et al.  Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. , 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

[140]  Ludivine Walter,et al.  The Homeobox Protein CEH-23 Mediates Prolonged Longevity in Response to Impaired Mitochondrial Electron Transport Chain in C. elegans , 2011, PLoS biology.

[141]  K. Davies,et al.  HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. , 2011, Free radical biology & medicine.

[142]  D. Gems,et al.  Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage , 2011, Free radical biology & medicine.

[143]  Christopher J. Murakami,et al.  Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae , 2011, PLoS genetics.

[144]  Peter M. Douglas,et al.  RPN-6 determines C. elegans longevity under proteotoxic stress conditions , 2012, Nature.

[145]  Christiane Ott,et al.  Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1. , 2012, The Biochemical journal.

[146]  R. S. Sohal,et al.  The redox stress hypothesis of aging. , 2012, Free radical biology & medicine.

[147]  Bradford W Gibson,et al.  Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan , 2012, Aging cell.

[148]  T. Morgan,et al.  Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. , 2012, Free radical biology & medicine.

[149]  K. Davies,et al.  Degradation of damaged proteins: the main function of the 20S proteasome. , 2012, Progress in molecular biology and translational science.

[150]  M. Andreeff,et al.  The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. , 2012, Blood.

[151]  K. Davies,et al.  Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress* , 2012, The Journal of Biological Chemistry.

[152]  Yael H. Edrey,et al.  Altered Composition of Liver Proteasome Assemblies Contributes to Enhanced Proteasome Activity in the Exceptionally Long-Lived Naked Mole-Rat , 2012, PloS one.

[153]  O. Eickelberg,et al.  Acute cigarette smoke exposure impairs proteasome function in the lung. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[154]  I. Fridovich.  Oxygen: How Do We Stand It? , 2012, Medical Principles and Practice.

[155]  K. Davies,et al.  Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. , 2012, Archives of biochemistry and biophysics.

[156]  V. Gorgoulis,et al.  Proteasome dysfunction in Drosophila signals to an Nrf2‐dependent regulatory circuit aiming to restore proteostasis and prevent premature aging , 2013, Aging cell.

[157]  Kaitlyn N. Lewis,et al.  The naked mole-rat response to oxidative stress: just deal with it. , 2013, Antioxidants & redox signaling.

[158]  H. Korswagen,et al.  Insulin/IGF-1-mediated longevity is marked by reduced protein metabolism , 2013, Molecular systems biology.

[159]  K. Davies,et al.  A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster , 2013, Journal of Experimental Biology.

[160]  R. Garcia-Valles,et al.  The free radical theory of aging revisited: the cell signaling disruption theory of aging. , 2013, Antioxidants & redox signaling.

[161]  M. Groettrup,et al.  The immunoproteasome in antigen processing and other immunological functions. , 2013, Current opinion in immunology.

[162]  D. Temiakov,et al.  Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease. , 2013, Molecular cell.

[163]  J. Tower,et al.  Oxidative stress adaptation with acute, chronic, and repeated stress. , 2013, Free radical biology & medicine.

[164]  A. Ruess,et al.  Mice with heterozygous deficiency of manganese superoxide dismutase (SOD2) have a skin immune system with features of “inflamm-aging” , 2014, Archives of Dermatological Research.

[165]  T. Nyström,et al.  Enhancing protein disaggregation restores proteasome activity in aged cells , 2013, Aging.

[166]  Takahiko Shimizu,et al.  Sod1 Loss Induces Intrinsic Superoxide Accumulation Leading to p53-Mediated Growth Arrest and Apoptosis , 2013, International journal of molecular sciences.

[167]  E. Liebau,et al.  The Glutathione Reductase GSR-1 Determines Stress Tolerance and Longevity in Caenorhabditis elegans , 2013, PloS one.

[168]  M. Kao,et al.  Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species , 2013, Cell Death and Disease.

[169]  Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities , 2014, AGE.

[170]  L. C. Pomatto,et al.  Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging , 2013, Redox biology.

[171]  B. Friguet,et al.  Deletion of the mitochondrial Pim1/Lon protease in yeast results in accelerated aging and impairment of the proteasome. , 2013, Free radical biology & medicine.

[172]  J. Hoseki,et al.  Mitochondrial impairment triggers cytosolic oxidative stress and cell death following proteasome inhibition , 2014, Scientific Reports.

[173]  M. Zeviani,et al.  Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. , 2014, The Biochemical journal.

[174]  M. S. Fernández-García,et al.  ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity. , 2014, Cell reports.

[175]  Ruth E. Thomas,et al.  PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix , 2014, PLoS genetics.

[176]  C. E. McCormack,et al.  Do you know the sex of your cells? , 2014, American journal of physiology. Cell physiology.

[177]  Hyung-Seok Kim,et al.  Nrf2, a Regulator of the Proteasome, Controls Self‐Renewal and Pluripotency in Human Embryonic Stem Cells , 2014, Stem cells.

[178]  N. Chandel,et al.  ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.

[179]  M. Watt,et al.  High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage. , 2014, Antioxidants & redox signaling.

[180]  A. Tesei,et al.  Silencing of mitochondrial Lon protease deeply impairs mitochondrial proteome and function in colon cancer cells , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[181]  Hui Song,et al.  Ameliorating replicative senescence of human bone marrow stromal cells by PSMB5 overexpression. , 2014, Biochemical and biophysical research communications.

[182]  Takahiko Shimizu,et al.  Superoxide Dismutase 1 Loss Disturbs Intracellular Redox Signaling, Resulting in Global Age-Related Pathological Changes , 2014, BioMed research international.

[183]  E. Epel,et al.  Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity. , 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

[184]  H. Sies.  Role of Metabolic H2O2 Generation , 2014, The Journal of Biological Chemistry.

[185]  J. Marcusson,et al.  Proteasome inhibition induces stress kinase dependent transport deficits — Implications for Alzheimer's disease , 2014, Molecular and Cellular Neuroscience.

[186]  Zhengdong D. Zhang,et al.  DNA repair in species with extreme lifespan differences , 2015, Aging.

[187]  L. C. Pomatto,et al.  The Immunoproteasome in oxidative stress, aging, and disease , 2016, Critical reviews in biochemistry and molecular biology.

[188]  Richard A. Miller,et al.  Lifespan of mice and primates correlates with immunoproteasome expression. , 2015, The Journal of clinical investigation.

[189]  U. Galderisi,et al.  Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells , 2015, Oncotarget.

[190]  Yael H. Edrey,et al.  Regulation of Nrf2 signaling and longevity in naturally long-lived rodents , 2015, Proceedings of the National Academy of Sciences.

[191]  Nolan G. Ericson,et al.  Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice , 2015, Experimental Gerontology.

[192]  T. Homma,et al.  SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes. , 2015, Archives of biochemistry and biophysics.

[193]  K. Davies,et al.  Oxidative stress response and Nrf2 signaling in aging. , 2015, Free radical biology & medicine.

[194]  Nektarios Tavernarakis,et al.  20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[195]  E. Calabrese,et al.  What is hormesis and its relevance to healthy aging and longevity? , 2015, Biogerontology.

[196]  I. Laher,et al.  Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases , 2015, Oxidative medicine and cellular longevity.

[197]  L. C. Pomatto,et al.  Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways. , 2016, Molecular aspects of medicine.

[198]  Tobias Jung,et al.  Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts. , 2016, Free radical biology & medicine.

[199]  B. Friguet,et al.  Circadian modulation of proteasome activity and accumulation of oxidized protein in human embryonic kidney HEK 293 cells and primary dermal fibroblasts. , 2016, Free radical biology & medicine.

[200]  K. Davies,et al.  The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome , 2016, Free radical biology & medicine.

[201]  V. Haroutunian,et al.  Protein Expression of Proteasome Subunits in Elderly Patients with Schizophrenia , 2016, Neuropsychopharmacology.

[202]  K. Davies,et al.  Adaptive homeostasis. , 2016, Molecular aspects of medicine.

[203]  A. Józkowicz,et al.  Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism , 2016, Cellular and Molecular Life Sciences.

[204]  S. Bodine,et al.  Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis , 2016, Aging.

[205]  T. Chiba,et al.  KIAA0368-deficiency affects disassembly of 26S proteasome under oxidative stress condition. , 2016, Journal of biochemistry.

[206]  J. Roelofs,et al.  Phosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29 , 2016, Scientific Reports.

[207]  Bonet-CostaVicent,et al.  The Proteasome and Oxidative Stress in Alzheimer's Disease. , 2016 .

[208]  Sarah Wong,et al.  The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress , 2017, Current Biology.

[209]  Renee M. Brielmann,et al.  Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. , 2017, Cell reports.

[210]  Gorjan Alagic,et al.  #p , 2019, Quantum information & computation.

[211]  M. Cavinato,et al.  UVB-Induced Senescence of Human Dermal Fibroblasts Involves Impairment of Proteasome and Enhanced Autophagic Activity , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[212]  Age related alteration of the antioxidant/ inflammatory axis in human lung epithelial cells in response to nanoparticle challenge , 2017 .

[213]  N. Chondrogianni,et al.  Proteasome activation enhances stemness and lifespan of human mesenchymal stem cells , 2017, Free radical biology & medicine.

[214]  K. Davies,et al.  The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1 , 2017, Biological reviews of the Cambridge Philosophical Society.

[215]  Jennifer M. A. Tullet,et al.  The SKN‐1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms , 2017, Aging cell.

[216]  L. C. Pomatto,et al.  The role of declining adaptive homeostasis in ageing , 2017, The Journal of physiology.

[217]  K. Davies,et al.  Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans , 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

[218]  S. Espinoza,et al.  A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse , 2017, GeroScience.

[219]  Linked p-FOXO4, PSMD11, and proteasomal function deficiency in human oa chondrocytes drives differentiation loss , 2017 .

[220]  L. C. Pomatto,et al.  Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains. , 2017, Archives of biochemistry and biophysics.

[221]  E. Nishida,et al.  The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans. , 2017, Cell reports.

[222]  D. Sosnowska,et al.  A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1−/− mice is correlated to increased cellular senescence , 2016, Redox biology.

[223]  Amber C. Howard,et al.  Assessing Health Span in Caenorhabditis elegans: Lessons From Short-Lived Mutants , 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

[224]  L. C. Pomatto,et al.  The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster , 2017, Aging.

[225]  Ilan E. Chemmama,et al.  The proteasome-interacting Ecm29 protein disassembles the 26S proteasome in response to oxidative stress , 2017, The Journal of Biological Chemistry.

[226]  K. Davies,et al.  Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells , 2017, Redox biology.

[227]  T. Morgan,et al.  Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic‐derived nanoparticles (‘vehicular smog’) , 2018, Free radical biology & medicine.

[228]  Increased oxidative stress and coenzyme Q10 deficiency in centenarians , 2018, Journal of clinical biochemistry and nutrition.

[229]  L. C. Pomatto,et al.  Redox Regulation of Homeostasis and Proteostasis in Peroxisomes. , 2018, Physiological reviews.

[230]  K. Davies,et al.  Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis , 2018, The journals of gerontology. Series A, Biological sciences and medical sciences.

[231]  A. Gould,et al.  Early-life exposure to low-dose oxidants can increase longevity via microbiome remodelling in Drosophila , 2018, Nature Communications.