Saddle block with pethidine for perineal operations.

Saddle blockade with pethidine hydrochloride was performed in 111 patients undergoing short surgical operations on the perineum. A dose of 5% pethidine 0.5 mg kg-1 was injected to the subarachnoid space at L4-5 or L5-S1 with the patient in the sitting position. Sensory blockade was achieved in 5.28 +/- 1.43 min. This extended to the sacrococcygeal area, perineum, buttocks and posterior surface of thighs, and was followed 1-2 min later by motor blockade. During the operation the patients were stable haemodynamically and no respiratory depression was recorded. Sensory blockade lasted for 141 +/- 26.06 min and was followed by postoperative analgesia, the mean duration of which was 301 +/- 98.38 min. Postoperative neurological complications were recorded in three patients (2.7%): headache alone in one, headache associated with backache in one, and leg weakness, backache, nuchal rigidity and photophobia in another. Seven patients (6.3%) complained of itching, five patients (4.5%) of nausea and vomiting and two (1.8%) developed urinary retention.

[1]  E. Poukkula.  The problem of post-spinal headache. , 1984, Annales chirurgiae et gynaecologiae.

[2]  P. Bromage.  Spinal opiate analgesia: its present role and future in pain relief. , 1984, Annales chirurgiae et gynaecologiae.

[3]  L. Mather,et al.  Intrathecal and epidural administration of opioids. , 1984, Anesthesiology.

[4]  V. Bloom.  Martindale: The Extra Pharmacopoeia: 28th edn , 1983 .

[5]  L. Mather,et al.  Peridural Meperidine in Humans: Analgetic Response, Pharmacokinetics, and Transmission into CSF , 1982 .

[6]  P. Bromage,et al.  Nonrespiratory Side Effects of Epidural Morphine , 1982, Anesthesia and analgesia.

[7]  C. Ene,et al.  L'anesthésie sous-arachnoïdienne par la péthidine , 1982 .

[8]  N. Rawal,et al.  Postoperative Pain Relief by Epidural Morphine , 1981, Anesthesia and analgesia.

[9]  L. Kaukinen,et al.  The prevention of headache following spinal anaesthesia. , 1981, Annales chirurgiae et gynaecologiae.

[10]  B. Smith,et al.  Continuous epidural infusion of fentanyl for postoperative analgesia , 1980, Anaesthesia.

[11]  P. Bromage,et al.  Epidural Narcotics for Postoperative Analgesia , 1980, Anesthesia and analgesia.

[12]  L. Mather,et al.  SELECTIVE SPINAL ANALGESIA , 1979, The Lancet.

[13]  F. Magora,et al.  EPIDURAL MORPHINE IN TREATMENT OF PAIN , 1979, The Lancet.

[14]  K. Austin,et al.  A Pharmacokinetic Approach to Postoperative Pain: Continuous Infusion of Pethidine , 1979, Anaesthesia and intensive care.

[15]  John E. Thomas,et al.  Pain relief by intrathecally applied morphine in man. , 1979, Anesthesiology.

[16]  R. Maynard,et al.  The Pharmacological Basis of Therapeutics. 9th ed , 1997 .

[17]  A Cowan,et al.  Narcotic analgesics and antagonists. , 1971, Annual review of pharmacology.