Platelet Microparticle Controversial Role in Cancer

Platelet-derived microparticles (PMPs) are a group of micrometer-scale extracellular vesicles released by platelets upon activation that are responsible for the majority of microvesicles found in plasma. PMPs’ physiological properties and functions have long been investigated by researchers. In this regard, a noticeable area of studies has been devoted to evaluating the potential roles and effects of PMPs on cancer progression. Clinical and experimental evidence conflictingly implicates supportive and suppressive functions for PMPs regarding cancer. Many of these functions could be deemed as a cornerstone for future considerations of PMPs usage in cancer targeted therapy. This review discusses what is currently known about PMPs and provides insights for new and possible research directions for further grasping the intricate interplay between PMPs and cancer.

[1]  K. Segawa,et al.  Flippase and scramblase for phosphatidylserine exposure. , 2019, Current opinion in immunology.

[2]  P. Meikle,et al.  Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability , 2019, Thrombosis and Haemostasis.

[3]  P. Heller,et al.  Platelets as Mediators of Thromboinflammation in Chronic Myeloproliferative Neoplasms , 2019, Front. Immunol..

[4]  E. Tremoli,et al.  Biology and Role of Extracellular Vesicles (EVs) in the Pathogenesis of Thrombosis , 2019, International journal of molecular sciences.

[5]  T. Benameur,et al.  Molecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury in Cardiovascular Complications Associated with Diabetes , 2019, Oxidative medicine and cellular longevity.

[6]  Sang Kook Lee,et al.  The Role of Platelets in the Tumor-Microenvironment and the Drug Resistance of Cancer Cells , 2019, Cancers.

[7]  Jing Xu,et al.  Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines , 2018, Journal of Extracellular Vesicles.

[8]  C. Dubois,et al.  Impacts of Cancer on Platelet Production, Activation and Education and Mechanisms of Cancer-Associated Thrombosis , 2018, Cancers.

[9]  A. Gasbarrini,et al.  Microparticles Produced by Activated Platelets Carry a Potent and Functionally Active Angiogenic Signal in Subjects with Crohn’s Disease , 2018, International journal of molecular sciences.

[10]  Y. Ozaki,et al.  Platelets play an essential role in murine lung development through Clec-2/podoplanin interaction. , 2018, Blood.

[11]  J. Boyne,et al.  Platelet microparticle delivered microRNA-Let-7a promotes the angiogenic switch. , 2018, Biochimica et biophysica acta. Molecular basis of disease.

[12]  H. Schwertz,et al.  Platelets and their Microparticles go hand in hand. , 2018, Thrombosis research.

[13]  O. Casanovas,et al.  Unraveling the Role of Angiogenesis in Cancer Ecosystems , 2018, Frontiers in Oncology.

[14]  P. Patrignani,et al.  Platelets and extracellular vesicles in cancer: diagnostic and therapeutic implications , 2018, Cancer and Metastasis Reviews.

[15]  Z. Zeng,et al.  The Role of Platelet Microparticle Associated microRNAs in Cellular Crosstalk , 2018, fcvm.

[16]  L. Goldfinger,et al.  Platelet Microparticles and miRNA Transfer in Cancer Progression: Many Targets, Modes of Action, and Effects Across Cancer Stages , 2018, Front. Cardiovasc. Med..

[17]  P. Kurre,et al.  Extracellular vesicles in the hematopoietic microenvironment , 2018, Haematologica.

[18]  Rui Qiao,et al.  Tissue Factor-bearing MPs and the risk of venous thrombosis in cancer patients: A meta-analysis , 2018, Scientific Reports.

[19]  Mehran Ghasemzadeh,et al.  Induction of Apoptosis in Cancer Cells of pre-B ALL Patients after Exposure to Platelets, Platelet-Derived Microparticles and Soluble CD40 Ligand , 2018, Cell journal.

[20]  Lu Jiang,et al.  Platelet microparticle-mediated transfer of miR-939 to epithelial ovarian cancer cells promotes epithelial to mesenchymal transition , 2017, Oncotarget.

[21]  K. Simon,et al.  Influence of Diabetes on Circulating Apoptotic Microparticles in Patients with Chronic Hepatitis C. , 2017, In vivo.

[22]  M. Madesh,et al.  Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. , 2017, Blood.

[23]  É. Boilard.  Platelet-derived nanomedicine targets cancer. , 2017, Blood.

[24]  W. Shen,et al.  Clinical significance of circulating microparticles in Ph- myeloproliferative neoplasms. , 2017, Oncology letters.

[25]  E. Lazaro,et al.  New Insights on Platelets and Platelet-Derived Microparticles in Systemic Lupus Erythematosus , 2017, Current Rheumatology Reports.

[26]  C. Villa,et al.  Release of Prometastatic Platelet-Derived Microparticles Induced by Breast Cancer Cells: A Novel Positive Feedback Mechanism for Metastasis , 2017, TH Open.

[27]  Mehran Ghasemzadeh,et al.  Induction of apoptosis in human tumor cell lines by platelets , 2017 .

[28]  S. Tucker,et al.  Platelets and cancer angiogenesis nexus , 2017, Cancer and Metastasis Reviews.

[29]  L. Rauova,et al.  Intracellular origin and ultrastructure of platelet‐derived microparticles , 2017, Journal of thrombosis and haemostasis : JTH.

[30]  Zhou Zhou,et al.  Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis , 2017, Cellular Physiology and Biochemistry.

[31]  L. Edelstein.  The role of platelet microvesicles in intercellular communication , 2017, Platelets.

[32]  Jennifer C. Jones,et al.  Detection of platelet vesicles by flow cytometry , 2017, Platelets.

[33]  S. Biffo,et al.  Role of microRNAs in translation regulation and cancer , 2017, World journal of biological chemistry.

[34]  É. Boilard,et al.  Platelet microvesicles in health and disease , 2017, Platelets.

[35]  L. Wuescher,et al.  Cancer and Thrombosis: The Platelet Perspective , 2017, Front. Cell Dev. Biol..

[36]  M. Hessner,et al.  TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice. , 2016, Blood advances.

[37]  Yan Chen,et al.  Higher Plasma Concentrations of Platelet Microparticles in Patients With Acute Coronary Syndrome: A Systematic Review and Meta-analysis. , 2016, The Canadian journal of cardiology.

[38]  P. Nigrovic,et al.  Revealing the diversity of extracellular vesicles using high-dimensional flow cytometry analyses , 2016, Scientific Reports.

[39]  A. Winnicka,et al.  The biology of extracellular vesicles with focus on platelet microparticles and their role in cancer development and progression , 2016, Tumor Biology.

[40]  S. Sadallah,et al.  Platelet-Derived Ectosomes Reduce NK Cell Function , 2016, The Journal of Immunology.

[41]  Yan-Wei Hu,et al.  Possible roles of platelet-derived microparticles in atherosclerosis. , 2016, Atherosclerosis.

[42]  U. Hedin,et al.  Heparanase expression upregulates platelet adhesion activity and thrombogenicity , 2016, Oncotarget.

[43]  I. Joosten,et al.  Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin. , 2016, Blood.

[44]  Jialan Shi,et al.  Phosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients , 2016, Journal of Experimental & Clinical Cancer Research.

[45]  B. Dahlbäck,et al.  The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles* , 2016, The Journal of Biological Chemistry.

[46]  N. V. Golubeva,et al.  Activity of tissue factor in microparticles produced in vitro by endothelial cells, monocytes, granulocytes, and platelets , 2016, Biochemistry (Moscow).

[47]  C. Dubois,et al.  The origin and concentration of circulating microparticles differ according to cancer type and evolution: A prospective single‐center study , 2016, International journal of cancer.

[48]  J. Jia,et al.  Elevated Level of Circulating Platelet-derived Microparticles in Oral Cancer , 2016, Journal of dental research.

[49]  A. Orekhov,et al.  Endothelial Barrier and Its Abnormalities in Cardiovascular Disease , 2015, Front. Physiol..

[50]  K. Peter,et al.  Staphylococcal SSL5-induced platelet microparticles provoke proinflammatory responses via the CD40/TRAF6/NFKB signalling pathway in monocytes , 2015, Thrombosis and Haemostasis.

[51]  J. Seghatchian,et al.  Platelet-derived microparticles trigger THP-1 monocytic cell aggregation and release of pro-coagulant tissue factor-expressing microparticles in vitro. , 2015, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[52]  J. Seghatchian,et al.  Platelet microparticles and cancer: An intimate cross-talk. , 2015, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[53]  S. Nagata,et al.  TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets , 2015, Proceedings of the National Academy of Sciences.

[54]  S. Meuth,et al.  Platelets induce apoptosis via membrane-bound FasL. , 2015, Blood.

[55]  P. Provost,et al.  Platelet microparticles reprogram macrophage gene expression and function , 2015, Thrombosis and Haemostasis.

[56]  É. Boilard,et al.  The diversity of platelet microparticles , 2015, Current opinion in hematology.

[57]  K. Vijayan,et al.  Platelets and Their Interactions with Other Immune Cells. , 2015, Comprehensive Physiology.

[58]  M. Gelb,et al.  Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA , 2015, Proceedings of the National Academy of Sciences.

[59]  D. Varon,et al.  Platelets and their microparticles as key players in pathophysiological responses , 2015, Journal of thrombosis and haemostasis : JTH.

[60]  Penelope V Dalla,et al.  Microparticles in cancer: A review of recent developments and the potential for clinical application. , 2015, Seminars in cell & developmental biology.

[61]  Hongwei Liang,et al.  MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3 , 2015, Molecular Cancer.

[62]  S. Opal,et al.  Endothelial barrier dysfunction in septic shock , 2015, Journal of internal medicine.

[63]  Yi Jing,et al.  Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs , 2015, Proceedings of the National Academy of Sciences.

[64]  O. Garraud,et al.  Breaking the Mold: Transcription Factors in the Anucleate Platelet and Platelet-Derived Microparticles , 2015, Front. Immunol..

[65]  I. Plante,et al.  Dissociation of SERPINE1 mRNA from the translational repressor proteins Ago2 and TIA-1 upon platelet activation , 2015, Thrombosis and Haemostasis.

[66]  M. Peter,et al.  The role of CD95 and CD95 ligand in cancer , 2015, Cell Death and Differentiation.

[67]  J. Seghatchian,et al.  Platelet microparticle: a sensitive physiological "fine tuning" balancing factor in health and disease. , 2015, Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.

[68]  M. Gelb,et al.  Detection and Quantification of Microparticles from Different Cellular Lineages Using Flow Cytometry. Evaluation of the Impact of Secreted Phospholipase A2 on Microparticle Assessment , 2015, PloS one.

[69]  S. Nomura,et al.  Clinical significance of procoagulant microparticles , 2015, Journal of Intensive Care.

[70]  J. Daoud,et al.  Impact of breast cancer stage, time from diagnosis and chemotherapy on plasma and cellular biomarkers of hypercoagulability , 2014, BMC Cancer.

[71]  Y. Richard,et al.  The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion , 2014, International journal of molecular sciences.

[72]  M. Gelb,et al.  Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. , 2014, Blood.

[73]  S. Sadallah,et al.  Ectosomes released by platelets induce differentiation of CD4+ T cells into T regulatory cells , 2014, Thrombosis and Haemostasis.

[74]  C. Holmes,et al.  Platelets in Tumor Progression: A Host Factor That Offers Multiple Potential Targets in the Treatment of Cancer , 2014, Journal of cellular physiology.

[75]  R. Hynes,et al.  Platelets guide the formation of early metastatic niches , 2014, Proceedings of the National Academy of Sciences.

[76]  Nader Sheibani,et al.  Diabetes and Retinal Vascular Dysfunction , 2014, Journal of ophthalmic & vision research.

[77]  B. Dahlbäck,et al.  Protein S and factor V in regulation of coagulation on platelet microparticles by activated protein C. , 2014, Thrombosis research.

[78]  M. Perretti,et al.  Cutting-Edge Analysis of Extracellular Microparticles using ImageStreamX Imaging Flow Cytometry , 2014, Scientific Reports.

[79]  T. Burnouf,et al.  Regulation of Tumor Growth and Metastasis: The Role of Tumor Microenvironment , 2014, Cancer growth and metastasis.

[80]  D. Farge,et al.  Involvement of platelet-derived microparticles in tumor progression and thrombosis. , 2014, Seminars in oncology.

[81]  Lesley M. Chapman,et al.  Emerging roles for platelets as immune and inflammatory cells. , 2014, Blood.

[82]  S. Mornet,et al.  Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration , 2014, Journal of thrombosis and haemostasis : JTH.

[83]  M. Bebawy,et al.  Cellular communication via microparticles: role in transfer of multidrug resistance in cancer. , 2014, Future oncology.

[84]  Anne Zufferey,et al.  Characterization of the platelet granule proteome: evidence of the presence of MHC1 in alpha-granules. , 2014, Journal of proteomics.

[85]  D. Coppola,et al.  TGF-β–inducible microRNA-183 silences tumor-associated natural killer cells , 2014, Proceedings of the National Academy of Sciences.

[86]  R. Silverstein,et al.  Proteasome Proteolysis Supports Stimulated Platelet Function and Thrombosis , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[87]  N. Webster,et al.  Role of Microparticles in Sepsis , 2013 .

[88]  P. Provost,et al.  Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles. , 2013, Blood.

[89]  T. Burnouf,et al.  The platelet-cancer loop. , 2013, European journal of internal medicine.

[90]  B. Olde,et al.  Platelets activated during myocardial infarction release functional miRNA which can be taken up by endothelial cells and regulate ICAM1 expression , 2013, Blood.

[91]  Hugh S Markus,et al.  Circulating MicroRNAs as Novel Biomarkers for Platelet Activation , 2013, Circulation research.

[92]  Ángel García,et al.  Comparative analysis of platelet-derived microparticles reveals differences in their amount and proteome depending on the platelet stimulus. , 2012, Journal of proteomics.

[93]  H. Kemona,et al.  Platelet-Derived Microparticles in Patients with Colorectal Cancer , 2012 .

[94]  I. Weiss,et al.  Tissue-Factor Bearing Microparticles and Thrombotic Risk in the Myeloproliferative Neoplasms , 2012 .

[95]  D. Varon,et al.  The role of platelets and their microparticles in rehabilitation of ischemic brain tissue. , 2012, CNS & neurological disorders drug targets.

[96]  D. Varon,et al.  Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration. , 2012, Thrombosis research.

[97]  E. Latz,et al.  Endothelial Microparticle Uptake in Target Cells Is Annexin I/Phosphatidylserine Receptor Dependent and Prevents Apoptosis , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[98]  A. Brill,et al.  Platelet microparticles induce angiogenesis and neurogenesis after cerebral ischemia. , 2012, Current neurovascular research.

[99]  T. Tokuhisa,et al.  CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema. , 2012, American journal of physiology. Lung cellular and molecular physiology.

[100]  W. Baldwin,et al.  Platelets Present Antigen in the Context of MHC Class I , 2012, The Journal of Immunology.

[101]  H. Büller,et al.  Coagulation activation and microparticle-associated coagulant activity in cancer patients , 2012, Thrombosis and Haemostasis.

[102]  J. Freedman,et al.  Platelets and platelet-like particles mediate intercellular RNA transfer. , 2012, Blood.

[103]  G. Grau,et al.  Microparticles and their emerging role in cancer multidrug resistance. , 2012, Cancer treatment reviews.

[104]  A. Falanga,et al.  Microparticles in tumor progression. , 2012, Thrombosis research.

[105]  P. Siljander,et al.  Platelet-Derived Microvesicles: Multitalented Participants in Intercellular Communication , 2012, Seminars in Thrombosis & Hemostasis.

[106]  Mark Ziemann,et al.  Microparticles: major transport vehicles for distinct microRNAs in circulation , 2012, Cardiovascular research.

[107]  Clotilde Théry,et al.  Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses , 2011, Traffic.

[108]  R. Koenen,et al.  Microparticles from apoptotic platelets promote resident macrophage differentiation , 2011, Cell Death and Disease.

[109]  J. Freyssinet,et al.  Microparticles: a critical component in the nexus between inflammation, immunity, and thrombosis , 2011, Seminars in Immunopathology.

[110]  S. Sadallah,et al.  Microparticles (Ectosomes) Shed by Stored Human Platelets Downregulate Macrophages and Modify the Development of Dendritic Cells , 2011, The Journal of Immunology.

[111]  N. Mackman,et al.  Microparticles in Hemostasis and Thrombosis , 2011, Circulation research.

[112]  P. Simioni,et al.  Endothelial, platelet, and tissue factor-bearing microparticles in cancer patients with and without venous thromboembolism. , 2011, Thrombosis research.

[113]  J. Ware,et al.  Platelets Participate in Synovitis via Cox-1–Dependent Synthesis of Prostacyclin Independently of Microparticle Generation , 2011, The Journal of Immunology.

[114]  G. Camussi,et al.  The role of microvesicles in tissue repair , 2011, Organogenesis.

[115]  J. Freedman,et al.  Platelets and the immune continuum , 2011, Nature Reviews Immunology.

[116]  J. Freyssinet,et al.  Cellular Mechanisms Underlying the Formation of Circulating Microparticles , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[117]  G. Lip,et al.  Circulating microparticles in cardiovascular disease: implications for atherogenesis and atherothrombosis , 2010, Journal of thrombosis and haemostasis : JTH.

[118]  P. Asfar,et al.  Bench-to-bedside review: Circulating microparticles - a new player in sepsis? , 2010, Critical care.

[119]  D. Ye,et al.  Microparticles mediate enzyme transfer from platelets to mast cells: a new pathway for lipoxin A4 biosynthesis. , 2010, Biochemical and biophysical research communications.

[120]  F. De Haas,et al.  The platelet interior revisited: electron tomography reveals tubular alpha-granule subtypes. , 2010, Blood.

[121]  M. Hristov,et al.  Platelet Microparticles Enhance the Vasoregenerative Potential of Angiogenic Early Outgrowth Cells After Vascular Injury , 2010, Circulation.

[122]  H. ten Cate,et al.  Elevated numbers and altered subsets of procoagulant microparticles in breast cancer patients using endocrine therapy. , 2010, Thrombosis research.

[123]  J. Freyssinet,et al.  Formation of procoagulant microparticles and properties. , 2010, Thrombosis research.

[124]  Richard W. Farndale,et al.  Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production , 2010, Science.

[125]  D. Varon,et al.  Role of platelet-derived microparticles in angiogenesis and tumor progression. , 2009, Discovery medicine.

[126]  Timothy D Cummins,et al.  Proteomic and functional characterisation of platelet microparticle size classes , 2009, Thrombosis and Haemostasis.

[127]  G. Grau,et al.  Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells , 2009, Leukemia.

[128]  S. Oudard,et al.  Platelet microparticles: a potential predictive factor of survival in hormone-refractory prostate cancer patients treated with docetaxel-based chemotherapy. , 2009, European urology.

[129]  Qingbo Xu,et al.  Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. , 2009, Blood.

[130]  Alexander Brill,et al.  Platelet‐derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP‐2 production , 2009, International journal of cancer.

[131]  B. Brenner,et al.  Microparticles, thrombosis and cancer. , 2009, Best practice & research. Clinical haematology.

[132]  R. Flaumenhaft,et al.  Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles. , 2009, Blood.

[133]  Lianbo Yu,et al.  Detection of microRNA Expression in Human Peripheral Blood Microvesicles , 2008, PloS one.

[134]  I. Bauerfeind,et al.  Platelet-derived microparticles and coagulation activation in breast cancer patients , 2008, Thrombosis and Haemostasis.

[135]  Tullio Pozzan,et al.  CXCR4–CCR5: A couple modulating T cell functions , 2008, Proceedings of the National Academy of Sciences.

[136]  F. Violi,et al.  Tumour necrosis factor alpha upregulates platelet CD40L in patients with heart failure. , 2008, Cardiovascular research.

[137]  T. Ratliff,et al.  Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. , 2008, Blood.

[138]  J. Folkman,et al.  Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released. , 2008, Blood.

[139]  J. Freyssinet,et al.  Platelet microparticles and vascular cells interactions: A checkpoint between the haemostatic and thrombotic responses , 2008, Platelets.

[140]  W. Yin,et al.  Expression of complement components and inhibitors on platelet microparticles , 2008, Platelets.

[141]  M. Tesselaar,et al.  Risk of venous thromboembolism in lung cancer , 2007, Current opinion in pulmonary medicine.

[142]  Mikhail A Panteleev,et al.  Platelet microparticle membranes have 50- to 100-fold higher specific procoagulant activity than activated platelets , 2007, Thrombosis and Haemostasis.

[143]  S. Eichinger,et al.  Tissue factor-positive microparticles: Cellular origin and association with coagulation activation in patients with colorectal cancer , 2006, Thrombosis and Haemostasis.

[144]  H. Deckmyn,et al.  Platelet microparticle formation and thrombin generation under high shear are effectively suppressed by a monoclonal antibody against GPIbα , 2006, Thrombosis and Haemostasis.

[145]  J Ratajczak,et al.  Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication , 2006, Leukemia.

[146]  Hui-Chin Peng,et al.  Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activation. , 2006, Journal of biomedical science.

[147]  R. Bertina,et al.  Microparticle‐associated tissue factor activity: a link between cancer and thrombosis? , 2007, Journal of thrombosis and haemostasis : JTH.

[148]  R. Flaumenhaft.  Formation and fate of platelet microparticles. , 2006, Blood cells, molecules & diseases.

[149]  D. Pisetsky,et al.  Microparticles as mediators of cellular cross-talk in inflammatory disease , 2006, Autoimmunity.

[150]  C. Sáez,et al.  Circulating platelet-derived microparticles in systemic lupus erythematosus , 2005, Thrombosis and Haemostasis.

[151]  D. Pisetsky,et al.  Microparticles as regulators of inflammation: novel players of cellular crosstalk in the rheumatic diseases. , 2005, Arthritis and rheumatism.

[152]  H. Kitayama,et al.  Significance of elevation in cell-derived microparticles after allogeneic stem cell transplantation: transient elevation of platelet-drived microparticles in TMA/TTP , 2005, Bone Marrow Transplantation.

[153]  José A López,et al.  Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. , 2005, Blood.

[154]  Christian Weber,et al.  Platelet Microparticles: A Transcellular Delivery System for RANTES Promoting Monocyte Recruitment on Endothelium , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[155]  L. Horstman,et al.  Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism. , 2005, Journal of the American College of Cardiology.

[156]  M. Matsumura,et al.  Increased levels of platelet-derived microparticles in patients with diabetic retinopathy. , 2005, Diabetes research and clinical practice.

[157]  Anna Janowska-Wieczorek,et al.  Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer , 2005, International journal of cancer.

[158]  D. McDonald,et al.  Cellular abnormalities of blood vessels as targets in cancer. , 2005, Current opinion in genetics & development.

[159]  A. Brill,et al.  Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization. , 2004, Cardiovascular research.

[160]  H. K. Kim,et al.  Platelet microparticles induce angiogenesis in vitro , 2004, British journal of haematology.

[161]  M. Tomasson,et al.  Platelet and osteoclast β3 integrins are critical for bone metastasis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[162]  H. Tilg,et al.  CD40 Ligand-Dependent Maturation of Human Monocyte-Derived Dendritic Cells by Activated Platelets , 2003, International journal of immunopathology and pharmacology.

[163]  L. Horstman,et al.  High levels of circulating endothelial microparticles in patients with acute coronary syndromes. , 2003, American heart journal.

[164]  A. Matzdorff,et al.  Markers of platelet activation and platelet-leukocyte interaction in patients with myeloproliferative syndromes. , 2002, Thrombosis research.

[165]  M. Brown,et al.  Platelet activation in the hypertensive disorders of pregnancy , 2002, American journal of obstetrics and gynecology.

[166]  R. Nieuwland,et al.  Enhanced Coagulation Activation in Preeclampsia: the Role of APC Resistance, Microparticles and Other Plasma Constituents , 2002, Thrombosis and Haemostasis.

[167]  Johan W M Heemskerk,et al.  Platelet Activation and Blood Coagulation , 2002, Thrombosis and Haemostasis.

[168]  D. Praticò,et al.  Platelet-derived microparticles stimulate proliferation, survival, adhesion, and chemotaxis of hematopoietic cells. , 2002, Experimental hematology.

[169]  M. Ratajczak,et al.  Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. , 2001, Blood.

[170]  C. Hack,et al.  Cell-derived Microparticles Circulate in Healthy Humans and Support Low Grade Thrombin Generation , 2001, Thrombosis and Haemostasis.

[171]  T. Kuijpers,et al.  The impact of platelet‐activating factor (PAF)‐like mediators on the functional activity of neutrophils: anti‐inflammatory effects of human PAF‐acetylhydrolase , 2001, Clinical and experimental immunology.

[172]  G. FitzGerald,et al.  Modulation of monocyte-endothelial cell interactions by platelet microparticles. , 1998, The Journal of clinical investigation.

[173]  G. FitzGerald,et al.  Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. , 1997, The Journal of clinical investigation.

[174]  E. Chargaff,et al.  The biological significance of the thromboplastic protein of blood. , 1946, The Journal of biological chemistry.

[175]  H. Mirzaei,et al.  Role of microRNAs in chronic lymphocytic leukemia pathogenesis. , 2019, Current medicinal chemistry.

[176]  M. Linden.  Platelet physiology. , 2013, Methods in molecular biology.

[177]  P. Siljander,et al.  Platelet-derived microparticles - an updated perspective. , 2011, Thrombosis research.

[178]  F. D. Haas,et al.  The platelet interior revisited : electron tomography reveals tubular-granule subtypes , 2010 .

[179]  Hongliang Cong,et al.  Platelet-derived microparticles and the potential of glycoprotein IIb/IIIa antagonists in treating acute coronary syndrome. , 2009, Texas Heart Institute journal.

[180]  S. Kunapuli,et al.  Role of P2Y receptor subtypes in platelet-derived microparticle generation. , 2008, Frontiers in bioscience : a journal and virtual library.

[181]  H. K. Kim,et al.  Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor. , 2003, European journal of cancer.

[182]  S. Nomura,et al.  Differences between platelet and microparticle glycoprotein IIb/IIIa. , 1992, Cytometry.

[183]  A. F. Bykovsky,et al.  Platelet-mediated cytotoxicity and its enhancement by platelet activating factor. , 1991, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.