Volumetric investigation of the frontal-subcortical circuitry in patients with obsessive-compulsive disorder.

The pathophysiology of obsessive-compulsive disorder (OCD) is thought to involve disturbance of the frontal-subcortical circuitry. To investigate the morphological characteristics of this circuitry, we examined the volume of the orbitofrontal cortex, anterior cingulate, thalamus, caudate, and the putamen in 36 age- and sex-matched OCD patients and normal control subjects using three-dimensional magnetic resonance (MR) brain imaging. The left orbitofrontal volumes were found to be significantly smaller in the OCD patients and showed significant negative correlations with obsessive-compulsive symptom severity. These findings suggest that a structural abnormality of this brain region is implicated in the pathophysiology of OCD.

[1]  A L Brody,et al.  Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder , 1998, British Journal of Psychiatry.

[2]  S. Rauch,et al.  Neuroimaging and neuropsychology of the striatum. Bridging basic science and clinical practice. , 1997, The Psychiatric clinics of North America.

[3]  R. Rubin,et al.  Regional xenon 133 cerebral blood flow and cerebral technetium 99m HMPAO uptake in unmedicated patients with obsessive-compulsive disorder and matched normal control subjects. Determination by high-resolution single-photon emission computed tomography. , 1992, Archives of general psychiatry.

[4]  R. Mennella,et al.  Huntington's disease and its association with psychopathology. , 2000, Harvard review of psychiatry.

[5]  M Ashtari,et al.  Reduced caudate nucleus volume in obsessive-compulsive disorder. , 1995, Archives of general psychiatry.

[6]  Martha Elizabeth Shenton,et al.  Voxel-Based Morphometric Analysis of Gray Matter in First Episode Schizophrenia , 2002, NeuroImage.

[7]  W. Goodman,et al.  The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. , 1989, Archives of general psychiatry.

[8]  D. Rosenberg,et al.  Proton spectroscopic imaging of the thalamus in treatment-naive pediatric obsessive–compulsive disorder∗ , 2000, Biological Psychiatry.

[9]  H. Duvernoy,et al.  The Human Brain: Surface, Three-Dimensional Sectional Anatomy with MRI, and Blood Supply , 1999 .

[10]  Ron Kikinis,et al.  Volumetric Evaluation of the Thalamus in Schizophrenic Male Patients Using Magnetic Resonance Imaging , 1998, Biological Psychiatry.

[11]  Dan J Stein,et al.  Computed tomography and neurological soft signs in obsessive-compulsive disorder , 1993, Psychiatry Research: Neuroimaging.

[12]  O. Speck,et al.  1H-magnetic resonance spectroscopy in obsessive-compulsive disorder: evidence for neuronal loss in the cingulate gyrus and the right striatum , 1997, Psychiatry Research: Neuroimaging.

[13]  A. B. Hollingshead,et al.  Social Class and Mental Illness: A Community Study. , 1958 .

[14]  S. Alborzian,et al.  Localized Orbitofrontal and Subcortical Metabolic Changes and Predictors of Response to Paroxetine Treatment in Obsessive-Compulsive Disorder , 1999, Neuropsychopharmacology.

[15]  R W Neufeld,et al.  A short echo 1H spectroscopy and volumetric MRI study of the corpus striatum in patients with obsessive-compulsive disorder and comparison subjects. , 1998, The American journal of psychiatry.

[16]  S. Rauch,et al.  Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. , 2000, The Psychiatric clinics of North America.

[17]  M. Annett.  A classification of hand preference by association analysis. , 1970, British journal of psychology.

[18]  John L. Bradshaw,et al.  The Neurodevelopmental Frontostriatal Disorders: Evolutionary Adaptiveness and Anomalous Lateralization , 2000, Brain and Language.

[19]  S. Rauch,et al.  Structural abnormalities of frontal neocortex in obsessive-compulsive disorder. , 1998, Archives of General Psychiatry.

[20]  N. Alpert,et al.  Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. , 1994, Archives of general psychiatry.

[21]  James C. Bezdek,et al.  Efficient Implementation of the Fuzzy c-Means Clustering Algorithms , 1986, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[22]  D. Rosenberg,et al.  Increased Medial Thalamic Choline in Pediatric Obsessive-Compulsive Disorder as Detected by Quantitative in Vivo Spectroscopic Imaging , 2001, Journal of child neurology.

[23]  Daniel S. O'Leary,et al.  Human Frontal Cortex: An MRI-Based Parcellation Method , 1999, NeuroImage.

[24]  Michele Laraia,et al.  Brain MRI in obsessive-compulsive disorder , 1991, Psychiatry Research.

[25]  Hae-Jeong Park,et al.  Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive–compulsive disorder , 2003, Acta psychiatrica Scandinavica.

[26]  D. Zald,et al.  Anatomy and function of the orbital frontal cortex, II: Function and relevance to obsessive-compulsive disorder. , 1996, The Journal of neuropsychiatry and clinical neurosciences.

[27]  Jun Soo Kwon,et al.  Grey matter abnormalities in obsessive–compulsive disorder , 2001, British Journal of Psychiatry.

[28]  G Schlaug,et al.  Brain (A) symmetry in monozygotic twins. , 1995, Cerebral cortex.

[29]  V S Caviness,et al.  Cerebral structural abnormalities in obsessive-compulsive disorder. A quantitative morphometric magnetic resonance imaging study. , 1996, Archives of general psychiatry.

[30]  Matcheri S. Keshavan,et al.  Toward a Neurodevelopmental Model of Obsessive–Compulsive Disorder , 1998, Biological Psychiatry.

[31]  E. Aylward,et al.  Normal caudate nucleus in obsessive-compulsive disorder assessed by quantitative neuroimaging. , 1996, Archives of general psychiatry.

[32]  T. Insel,et al.  Toward a neuroanatomy of obsessive-compulsive disorder. , 1992, Archives of general psychiatry.

[33]  M Ashtari,et al.  Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder. , 1999, Archives of general psychiatry.

[34]  J. Kwon,et al.  Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive–compulsive disorder , 2003, Psychiatry Research: Neuroimaging.