KIR and disease: a model system or system of models?

Summary:  The discovery of an unexpected level of diversity among the killer cell immunoglobulin‐like receptors has led to a search for their role in human disease. Due to their polymorphism and also that of their human leukocyte antigen class I ligands, these studies are difficult to perform and complex to interpret. Nevertheless, as the number of data sets increase, consistent trends and themes are beginning to emerge in both viral and inflammatory disorders. In this review, we summarize the findings from a number of disease association studies and discuss these in the context of the activating and inhibitory roles of the members of this gene family.

[1]  C. Ober,et al.  The miscarriage-associated HLA-G -725G allele influences transcription rates in JEG-3 cells. , 2006, Human reproduction.

[2]  E. Thiel,et al.  Skewed expression of natural‐killer (NK)‐associated antigens on lymphoproliferations of large granular lymphocytes (LGL) , 2006, Hematological oncology.

[3]  P. Parham,et al.  High KIR diversity in Amerindians is maintained using few gene-content haplotypes , 2006, Immunogenetics.

[4]  P. Parham,et al.  Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function , 2006, The Journal of experimental medicine.

[5]  Y. Ge,et al.  HLA‐G polymorphism in a Chinese Han population with recurrent spontaneous abortion , 2006, International journal of immunogenetics.

[6]  J. Trowsdale,et al.  HLA-C and killer cell immunoglobulin-like receptor genes in idiopathic bronchiectasis. , 2006, American journal of respiratory and critical care medicine.

[7]  C. Meijer,et al.  HPV‐mediated cervical carcinogenesis: concepts and clinical implications , 2006, The Journal of pathology.

[8]  Eric O Long,et al.  Activation of NK Cells by an Endocytosed Receptor for Soluble HLA-G , 2005, PLoS biology.

[9]  C. Craddock,et al.  Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation. , 2005, Blood.

[10]  J. Orange,et al.  Natural killer cells in human health and disease. , 2006, Clinical immunology.

[11]  M. Carrington,et al.  The impact of variation at the KIR gene cluster on human disease. , 2006, Current topics in microbiology and immunology.

[12]  J. Trowsdale,et al.  Molecular characterization of KIR3DL3 , 2006, Immunogenetics.

[13]  C. Moore,et al.  Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progression , 2005, Genes and Immunity.

[14]  A. Fauci,et al.  NK cells in HIV infection: paradigm for protection or targets for ambush , 2005, Nature Reviews Immunology.

[15]  Hendrik Streeck,et al.  Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. , 2005, Blood.

[16]  Allan Hildesheim,et al.  Variation of the Killer Cell Immunoglobulin-Like Receptors and HLA-C Genes in Nasopharyngeal Carcinoma , 2005, Cancer Epidemiology Biomarkers & Prevention.

[17]  X. Chen,et al.  Human decidual NK cells form immature activating synapses and are not cytotoxic , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[18]  P. Parham,et al.  KIR3DL1 Polymorphisms That Affect NK Cell Inhibition by HLA-Bw4 Ligand1 , 2005, The Journal of Immunology.

[19]  Eric Vivier,et al.  Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[20]  M. Ståhle,et al.  Distinct HLA-C/KIR genotype profile associates with guttate psoriasis. , 2005, The Journal of investigative dermatology.

[21]  J. Partanen,et al.  Genetic diversity of KIR natural killer cell markers in populations from France, Guadeloupe, Finland, Senegal and Réunion. , 2005, Tissue antigens.

[22]  Rachel E. Owen,et al.  Shared Alterations in NK Cell Frequency, Phenotype, and Function in Chronic Human Immunodeficiency Virus and Hepatitis C Virus Infections , 2005, Journal of Virology.

[23]  Eric Vivier,et al.  Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[24]  L. Lybarger,et al.  Licensing of natural killer cells by host major histocompatibility complex class I molecules , 2005, Nature.

[25]  J. Trowsdale,et al.  Comparative Genomics of Natural Killer Cell Receptor Gene Clusters , 2005, PLoS genetics.

[26]  L. Rodrigo,et al.  Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection. , 2005, Journal of Infectious Diseases.

[27]  A. Bowcock,et al.  Activating killer cell immunoglobulin-like receptor gene KIR2DS1 is associated with psoriatic arthritis. , 2005, Human immunology.

[28]  I. Sargent,et al.  Latest Advances in Understanding Preeclampsia , 2005, Science.

[29]  F. Zhu,et al.  Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population. , 2005, Tissue antigens.

[30]  Ofer Levi,et al.  Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus , 2005, Nature Immunology.

[31]  Andrew Glass,et al.  Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci , 2005 .

[32]  Sumati Rajagopalan,et al.  Understanding how combinations of HLA and KIR genes influence disease , 2005, The Journal of experimental medicine.

[33]  Akiko Kikuchi-Maki,et al.  Cutting Edge: KIR2DL4 Transduces Signals into Human NK Cells through Association with the Fc Receptor γ Protein1 , 2005, The Journal of Immunology.

[34]  L. Rodrigo,et al.  Interaction between KIR3DL1 and HLA-B*57 supertype alleles influences the progression of HIV-1 infection in a Zambian population. , 2005, Human immunology.

[35]  B. Korber,et al.  Killer cell immunoglobulin‐like receptors (KIR) of the African‐origin sabaeus monkey: evidence for recombination events in the evolution of KIR , 2005, European journal of immunology.

[36]  P. Parham.  MHC class I molecules and kirs in human history, health and survival , 2005, Nature Reviews Immunology.

[37]  A. Fauci,et al.  Characterization of CD56-/CD16+ natural killer (NK) cells: a highly dysfunctional NK subset expanded in HIV-infected viremic individuals. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[38]  D. Whang,et al.  Haplotype analysis of killer cell immunoglobulin-like receptor genes in 77 Korean families. , 2005, Human immunology.

[39]  R. Tollenaar,et al.  Natural killer cells infiltrating colorectal cancer and MHC class I expression. , 2005, Molecular immunology.

[40]  A. Tefferi,et al.  Human leucocyte antigen class I and killer immunoglobulin‐like receptor expression patterns in T‐cell large granular lymphocyte leukaemia , 2005, British journal of haematology.

[41]  P. Tomasec,et al.  Downregulation of natural killer cell–activating ligand CD155 by human cytomegalovirus UL141 , 2005, Nature Immunology.

[42]  G. Feldmann,et al.  HIV-1 Infection Leads to Increased HLA-E Expression Resulting in Impaired Function of Natural Killer Cells , 2005, Antiviral therapy.

[43]  M. Carrington,et al.  Single haplotype analysis demonstrates rapid evolution of the killer immunoglobulin-like receptor (KIR) loci in primates. , 2005, Genome research.

[44]  Lewis L Lanier,et al.  NK cell recognition. , 2005, Annual review of immunology.

[45]  Milena Ivanova,et al.  Genetic polymorphism of NK receptors and their ligands in melanoma patients: prevalence of inhibitory over activating signals , 2005, Cancer Immunology, Immunotherapy.

[46]  L. Nikitina-Zake,et al.  Killer Cell Immunoglobulin‐like Receptor Genes in Latvian Patients with Type 1 Diabetes Mellitus and Healthy Controls , 2004, Annals of the New York Academy of Sciences.

[47]  E. Riley,et al.  Natural killer cells and innate immunity to protozoan pathogens. , 2004, International journal for parasitology.

[48]  N. Malats,et al.  Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. , 2004, Blood.

[49]  Dolca Thomas,et al.  Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[50]  M. Carrington,et al.  Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success , 2004, The Journal of experimental medicine.

[51]  E. Barker,et al.  Killing of human immunodeficiency virus-infected primary T-cell blasts by autologous natural killer cells is dependent on the ability of the virus to alter the expression of major histocompatibility complex class I molecules. , 2004, Blood.

[52]  M. Carrington,et al.  Cutting Edge: Heterozygote Advantage in Autoimmune Disease: Hierarchy of Protection/Susceptibility Conferred by HLA and Killer Ig-Like Receptor Combinations in Psoriatic Arthritis1 , 2004, The Journal of Immunology.

[53]  J. Moreau,et al.  Comparative analysis of NK cell subset distribution in normal and lymphoproliferative disease of granular lymphocyte conditions , 2004, European journal of immunology.

[54]  D. Raulet.  Interplay of natural killer cells and their receptors with the adaptive immune response , 2004, Nature Immunology.

[55]  L. Lanier,et al.  Cross-Talk between Activated Human NK Cells and CD4+ T Cells via OX40-OX40 Ligand Interactions1 , 2004, The Journal of Immunology.

[56]  P. Leibson,et al.  Stimulatory Killer Ig-Like Receptors Modulate T Cell Activation through DAP12-Dependent and DAP12-Independent Mechanisms1 , 2004, The Journal of Immunology.

[57]  K. Haugk,et al.  Prevalent expression of the immunostimulatory MHC class I chain-related molecule is counteracted by shedding in prostate cancer. , 2004, The Journal of clinical investigation.

[58]  Salim I. Khakoo,et al.  HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection , 2004, Science.

[59]  H. Achdout,et al.  MHC Class I-Independent Recognition of NK-Activating Receptor KIR2DS41 , 2004, The Journal of Immunology.

[60]  M. Mańczak,et al.  Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris. , 2004, Human immunology.

[61]  Arito Yamane,et al.  Characteristic expansion of CD45RA+ CD27− CD28− CCR7− lymphocytes with stable natural killer (NK) receptor expression in NK‐ and T‐cell type lymphoproliferative disease of granular lymphocytes , 2004, British journal of haematology.

[62]  M. Varla-Leftherioti,et al.  Role of a KIR/HLA-C allorecognition system in pregnancy. , 2004, Journal of reproductive immunology.

[63]  S. Rowland-Jones,et al.  Recognition of HLA‐A3 and HLA‐A11 by KIR3DL2 is peptide‐specific , 2004, European journal of immunology.

[64]  T. Sasazuki,et al.  Genetic polymorphisms of killer cell immunoglobulin-like receptors are associated with susceptibility to psoriasis vulgaris. , 2004, The Journal of investigative dermatology.

[65]  Sheng Wei,et al.  Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes. , 2004, Blood.

[66]  T. Krieg,et al.  Association of killer cell immunoglobulin-like receptors with scleroderma. , 2004, Arthritis and rheumatism.

[67]  M. Carrington,et al.  Justified chauvinism: advances in defining meiotic recombination through sperm typing. , 2004, Trends in genetics : TIG.

[68]  J. Hanna,et al.  Expression of KIR2DL1 on the entire NK cell population: a possible novel immunodeficiency syndrome. , 2004, Blood.

[69]  P. Parham,et al.  Domain Shuffling Has Been the Main Mechanism Forming New Hominoid Killer Cell Ig-Like Receptors1 , 2004, The Journal of Immunology.

[70]  P. Parham,et al.  The Protein Made from a Common Allele of KIR3DL1 (3DL1*004) Is Poorly Expressed at Cell Surfaces due to Substitution at Positions 86 in Ig Domain 0 and 182 in Ig Domain 1 1 , 2003, The Journal of Immunology.

[71]  M. Spyropoulou-Vlachou,et al.  Distribution of killer cell immunoglobulin-like receptors in the Greek population. , 2003, Human immunology.

[72]  Stephen J O'Brien,et al.  The influence of HLA genotype on AIDS. , 2003, Annual review of medicine.

[73]  M. Daucher,et al.  Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[74]  Peter Parham,et al.  Activation of a Subset of Human NK Cells upon Contact with Plasmodium falciparum-Infected Erythrocytes 1 , 2003, The Journal of Immunology.

[75]  P. Park,et al.  Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential , 2003, The Journal of experimental medicine.

[76]  Akiko Kikuchi-Maki,et al.  KIR2DL4 Is an IL-2-Regulated NK Cell Receptor That Exhibits Limited Expression in Humans but Triggers Strong IFN-γ Production1 , 2003, The Journal of Immunology.

[77]  B. Koeleman,et al.  KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. , 2003, Diabetes.

[78]  M. Carrington,et al.  Cutting Edge: Expansion of the KIR Locus by Unequal Crossing Over 1 , 2003, The Journal of Immunology.

[79]  A. Moretta,et al.  Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes. , 2003, Blood.

[80]  R. Frye,et al.  De Novo Expression of Killer Immunoglobulin‐Like Receptors and Signaling Proteins Regulates the Cytotoxic Function of CD4 T Cells in Acute Coronary Syndromes , 2003, Circulation research.

[81]  D. Briggs,et al.  The distribution of 13 killer-cell immunoglobulin-like receptor loci in UK blood donors from three ethnic groups. , 2003, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics.

[82]  L. Moretta,et al.  The natural killer cell‐mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig‐like receptors , 2003, European journal of immunology.

[83]  V. Lepage,et al.  Natural Killer (NK) Cell Receptors' Repertoire in Couples with Recurrent Spontaneous Abortions , 2003, American journal of reproductive immunology.

[84]  A. Tefferi,et al.  Demonstration of aberrant T‐cell and natural killer‐cell antigen expression in all cases of granular lymphocytic leukaemia , 2003, British journal of haematology.

[85]  C. Vilches,et al.  Recognition of HLA‐G by the NK cell receptor KIR2DL4 is not essential for human reproduction , 2003, European journal of immunology.

[86]  W. Yokoyama,et al.  Natural killer cells and viral infections. , 2003, Current opinion in immunology.

[87]  J. Orange.  Human natural killer cell deficiencies and susceptibility to infection. , 2002, Microbes and infection.

[88]  K. Hsu,et al.  The killer cell immunoglobulin‐like receptor (KIR) genomic region: gene‐order, haplotypes and allelic polymorphism , 2002, Immunological reviews.

[89]  P. Parham,et al.  NK cell-mediated lysis of autologous HCMV-infected skin fibroblasts is highly variable among NK cell clones and polyclonal NK cell lines. , 2002, Clinical immunology.

[90]  Eric Mickelson,et al.  Killer Ig-Like Receptor Haplotype Analysis by Gene Content: Evidence for Genomic Diversity with a Minimum of Six Basic Framework Haplotypes, Each with Multiple Subsets1 , 2002, The Journal of Immunology.

[91]  Kazuyoshi Takeda,et al.  New aspects of natural-killer-cell surveillance and therapy of cancer , 2002, Nature Reviews Cancer.

[92]  P. Parham,et al.  Predominance of group AKIR haplotypes in Japanese associated with diverse NK cell repertoires of KIR expression , 2002, Immunogenetics.

[93]  C. Yee,et al.  Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation , 2002, Nature.

[94]  Sunny Shin,et al.  The D0 Domain of KIR3D Acts as a Major Histocompatibility Complex Class I Binding Enhancer , 2002, The Journal of experimental medicine.

[95]  Michael J. Wilson,et al.  Cutting Edge: Susceptibility to Psoriatic Arthritis: Influence of Activating Killer Ig-Like Receptor Genes in the Absence of Specific HLA-C Alleles1 , 2002, The Journal of Immunology.

[96]  D Middleton,et al.  A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey. , 2002, Tissue antigens.

[97]  P. Leibson,et al.  Natural killer cell activation in mice and men: different triggers for similar weapons? , 2002, Nature Immunology.

[98]  I. Chung,et al.  Effects of Cytokines on VEGF Expression and Secretion by Human First Trimester Trophoblast Cell Line , 2002, American journal of reproductive immunology.

[99]  Keith Hoots,et al.  Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS , 2002, Nature Genetics.

[100]  James A. Hutchinson,et al.  Natural killer cells and reproduction. , 2002, Trends in immunology.

[101]  E. Adams,et al.  NK Cell Receptors of the Orangutan (Pongo pygmaeus): A Pivotal Species for Tracking the Coevolution of Killer Cell Ig-Like Receptors with MHC-C1 , 2002, The Journal of Immunology.

[102]  Peter Parham,et al.  Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B , 2002, Immunogenetics.

[103]  Markus Uhrberg,et al.  Definition of gene content for nine common group B haplotypes of the Caucasoid population: KIR haplotypes contain between seven and eleven KIR genes , 2002, Immunogenetics.

[104]  D. Fremont,et al.  Recognition of a virus-encoded ligand by a natural killer cell activation receptor , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[105]  L. Lanier,et al.  Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors , 2002, Science.

[106]  R. Vaughan,et al.  Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations , 2002, Genes and Immunity.

[107]  Heather G. Shilling,et al.  Allelic Polymorphism Synergizes with Variable Gene Content to Individualize Human KIR Genotype1 , 2002, The Journal of Immunology.

[108]  Giovanni Melioli,et al.  Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells , 2002, The Journal of experimental medicine.

[109]  G. Trinchieri,et al.  Reciprocal Activating Interaction between Natural Killer Cells and Dendritic Cells , 2002, The Journal of experimental medicine.

[110]  Diego Piccioli,et al.  Contact-dependent Stimulation and Inhibition of Dendritic Cells by Natural Killer Cells , 2002, The Journal of experimental medicine.

[111]  M. Smyth,et al.  The Role of NK Cells in Autoimmune Disease , 2002, Autoimmunity.

[112]  F. Christiansen,et al.  Alleles of the KIR2DL4 receptor and their lack of association with pre‐eclampsia , 2002, European journal of immunology.

[113]  Peter Parham,et al.  KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. , 2002, Annual review of immunology.

[114]  D. Doherty,et al.  Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy , 2002, Cancer Immunology, Immunotherapy.

[115]  P. Parham,et al.  Distinctive KIR and HLA diversity in a panel of north Indian Hindus , 2002, Immunogenetics.

[116]  L. Lanier,et al.  Biphasic response of NK cells expressing both activating and inhibitory killer Ig-like receptors. , 2001, International immunology.

[117]  M. Llano,et al.  Human cytomegalovirus and natural killer‐mediated surveillance of HLA class I expression: a paradigm of host–pathogen adaptation , 2001, Immunological reviews.

[118]  O. Mandelboim,et al.  Recognition of HLA-Cw4 but Not HLA-Cw6 by the NK Cell Receptor Killer Cell Ig-Like Receptor Two-Domain Short Tail Number 41 , 2001, The Journal of Immunology.

[119]  Daniel J. Schaid,et al.  Major Histocompatibility Complex Class I–Recognizing Receptors Are Disease Risk Genes in Rheumatoid Arthritis , 2001, The Journal of experimental medicine.

[120]  E. Rosenberg,et al.  Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[121]  D. Mager,et al.  Evolution of natural killer cell receptors coexistence of functional Ly49 and KIR genes in baboons , 2001, Current Biology.

[122]  J. McCluskey,et al.  Genomic diversity of natural killer cell receptor genes in three populations. , 2001, Tissue antigens.

[123]  N. Letvin,et al.  Diversity of the Killer Cell Ig-Like Receptors of Rhesus Monkeys1 2 , 2001, The Journal of Immunology.

[124]  P. Parham,et al.  The Repertoire of Killer Cell Ig-Like Receptor and CD94:NKG2A Receptors in T Cells: Clones Sharing Identical αβ TCR Rearrangement Express Highly Diverse Killer Cell Ig-Like Receptor Patterns1 , 2001, The Journal of Immunology.

[125]  P. Parham,et al.  Differential Expression of Leukocyte Receptor Complex-Encoded Ig-Like Receptors Correlates with the Transition from Effector to Memory CTL1 , 2001, The Journal of Immunology.

[126]  William H. Carr,et al.  Different NK Cell Surface Phenotypes Defined by the DX9 Antibody Are Due to KIR3DL1 Gene Polymorphism1 , 2001, The Journal of Immunology.

[127]  M. Bonneville,et al.  Regulation of Inhibitory and Activating Killer-Cell Ig-Like Receptor Expression Occurs in T Cells After Termination of TCR Rearrangements1 , 2001, The Journal of Immunology.

[128]  J. Strominger,et al.  The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[129]  Peter Parham,et al.  Short KIR Haplotypes in Pygmy Chimpanzee (Bonobo) Resemble the Conserved Framework of Diverse Human KIR Haplotypes , 2001, The Journal of experimental medicine.

[130]  P. Parham,et al.  Genetic control of human NK cell repertoire , 2001 .

[131]  F. Navarro,et al.  High expression of the ILT2 (LIR-1) inhibitory receptor for major histocompatibility complex class I molecules on clonal expansions of T large granular lymphocytes in asymptomatic patients. , 2001, Haematologica.

[132]  R. Vaughan,et al.  Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groups , 2001, Immunogenetics.

[133]  J. Yen,et al.  Killer Cell Activating Receptors Function as Costimulatory Molecules on CD4+CD28null T Cells Clonally Expanded in Rheumatoid Arthritis1 , 2000, The Journal of Immunology.

[134]  D. G. Muir,et al.  Rapid evolution of NK cell receptor systems demonstrated by comparison of chimpanzees and humans. , 2000, Immunity.

[135]  A. McMichael,et al.  HLA‐E is expressed on trophoblast and interacts with CD94 / NKG2 receptors on decidual NK cells , 2000, European journal of immunology.

[136]  Jeffrey C. Boyington,et al.  Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand , 2000, Nature.

[137]  J. Ellwart,et al.  Cutting Edge: The Human Cytomegalovirus UL40 Gene Product Contains a Ligand for HLA-E and Prevents NK Cell-Mediated Lysis1 , 2000, The Journal of Immunology.

[138]  J. Bowen,et al.  Surface expression of HLA-C antigen by human extravillous trophoblast. , 2000, Placenta.

[139]  C. Ober,et al.  A null mutation in HLA-G is not associated with preeclampsia or intrauterine growth retardation. , 2000, Journal of reproductive immunology.

[140]  A. McMichael,et al.  Surface expression of HLA-E, an inhibitor of natural killer cells, enhanced by human cytomegalovirus gpUL40. , 2000, Science.

[141]  H J Alter,et al.  Recovery, Persistence, and Sequelae in Hepatitis C Virus Infection: A Perspective on Long-Term Outcome , 2000, Seminars in liver disease.

[142]  C. Witt,et al.  Population frequencies and putative haplotypes of the killer cell immunoglobulin-like receptor sequences and evidence for recombination. , 1999, Transplantation.

[143]  G. Gao,et al.  Killer Cell Immunoglobulin Receptors and T Cell Receptors Bind Peptide-Major Histocompatibility Complex Class I with Distinct Thermodynamic and Kinetic Properties* , 1999, The Journal of Biological Chemistry.

[144]  R. Phyliky,et al.  A long‐term study of patients with chronic natural killer cell lymphocytosis , 1999, British journal of haematology.

[145]  R. Biassoni,et al.  P49, a putative HLA-G1 specific inhibitory NK receptor belonging to the immunoglobulin Superfamily. , 1999, Journal of reproductive immunology.

[146]  D. Baltimore,et al.  The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. , 1999, Immunity.

[147]  R. Biassoni,et al.  Inhibitory receptors sensing HLA-G1 molecules in pregnancy: decidua-associated natural killer cells express LIR-1 and CD94/NKG2A and acquire p49, an HLA-G1-specific receptor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[148]  Eric O Long,et al.  A Human Histocompatibility Leukocyte Antigen (HLA)-G–specific Receptor Expressed on All Natural Killer Cells , 1999, The Journal of experimental medicine.

[149]  D. Raulet.  Development and tolerance of natural killer cells. , 1999, Current opinion in immunology.

[150]  P. Ricciardi-Castagnoli,et al.  Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo , 1999, Nature Medicine.

[151]  C. Biron,et al.  Natural killer cells in antiviral defense: function and regulation by innate cytokines. , 1999, Annual review of immunology.

[152]  P. Parham,et al.  Evidence for recombination as a mechanism for KIR diversification , 1998, Immunogenetics.

[153]  Eric O Long,et al.  Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. , 1998, Journal of immunology.

[154]  C. Figdor,et al.  Killer cell inhibitory receptors for MHC class I molecules regulate lysis of melanoma cells mediated by NK cells, gamma delta T cells, and antigen-specific CTL. , 1998, Journal of immunology.

[155]  J. Orange,et al.  Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1α (MIP-1α)–dependent Pathways , 1998, The Journal of experimental medicine.

[156]  P Parham,et al.  Human diversity in killer cell inhibitory receptor genes. , 1997, Immunity.

[157]  R. Biassoni,et al.  Role of amino acid position 70 in the binding affinity of p50.1 and p58.1 receptors for HLA‐Cw4 molecules , 1997, European journal of immunology.

[158]  K. Parker,et al.  Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[159]  Eric O Long,et al.  The Direct Binding of a p58 Killer Cell Inhibitory Receptor to Human Histocompatibility Leukocyte Antigen (HLA)-Cw4 Exhibits Peptide Selectivity , 1997, The Journal of experimental medicine.

[160]  Y. W. Loke,et al.  Expression of killer cell inhibitory receptors on human uterine natural killer cells , 1997, European journal of immunology.

[161]  P. Coulie,et al.  Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. , 1997, Immunity.

[162]  P. Stern,et al.  Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. , 1997, Immunology today.

[163]  Eric O Long,et al.  Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells. , 1996, Journal of immunology.

[164]  E. Ren,et al.  Human leucocyte antigens and nasopharyngeal carcinoma. , 1996, Clinical science.

[165]  P. Parham,et al.  The inter-locus recombinant HLA-B*4601 has high selectivity in peptide binding and functions characteristic of HLA-C , 1996, The Journal of experimental medicine.

[166]  R. Biassoni,et al.  The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer , 1996, The Journal of experimental medicine.

[167]  K. Tokunaga,et al.  Chromosomal localization of the human natural killer cell class I receptor family genes to 19q13.4 by fluorescence in situ hybridization. , 1996, Genomics.

[168]  M. Colonna,et al.  A human killer inhibitory receptor specific for HLA-A1,2. , 1996, Journal of immunology.

[169]  Eric O Long,et al.  Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. , 1995, Immunity.

[170]  K. Lim,et al.  Human placental HLA-G expression is restricted to differentiated cytotrophoblasts. , 1995, Journal of immunology.

[171]  P. Parham,et al.  The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor , 1995, The Journal of experimental medicine.

[172]  G. Ferrara,et al.  NK3-specific natural killer cells are selectively inhibited by Bw4- positive HLA alleles with isoleucine 80 , 1994, The Journal of experimental medicine.

[173]  G. Ferrara,et al.  HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[174]  T. Loughran,et al.  Clonal diseases of large granular lymphocytes. , 1993, Blood.

[175]  A. Hughes,et al.  New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci , 1992, Nature.

[176]  M. Petzl-Erler,et al.  Unusual HLA-B alleles in two tribes of Brazilian Indians , 1992, Nature.

[177]  P. Parham,et al.  Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[178]  A. Scalzo,et al.  Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen , 1990, The Journal of experimental medicine.

[179]  M. Nei,et al.  Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci. , 1990, Genetics.

[180]  M. Nei,et al.  Evolution of the major histocompatibility complex: independent origin of nonclassical class I genes in different groups of mammals. , 1989, Molecular biology and evolution.

[181]  J L Sullivan,et al.  Severe herpesvirus infections in an adolescent without natural killer cells. , 1989, The New England journal of medicine.

[182]  M. Nei,et al.  Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection , 1988, Nature.

[183]  P. Hedrick,et al.  Evidence for balancing selection at HLA. , 1983, Genetics.

[184]  R. S. Rogers.  Genetics of psoriasis. , 1975, Minnesota medicine.