The frequency of invariant natural killer T cells correlates with the severity of myocarditis.

Abstract Invariant natural killer T cells (iNKT) perform different functions in different diseases. The cells were reported to protect myocarditis. However, the detail relationships between iNKT and Coxsackievirus B3 (CVB3)-induced myocarditis remain unclear. In order to investigate the correlation between the severity of CVB3-induced inflammation infiltration and the proportion of iNKT in the spleen and circulating blood, BALB/c mice were grouped into three groups according to the inflammation infiltration area of heart sections. The proportion of iNKT in CD3-positive cells in the spleen correlated negatively with the inflammation area (linear fit; R2=0.93) and virus capsid protein VP1 (linear fit; R2=0.84) in the myocardial tissue, while the proportion of iNKT in CD3-positive cells in the PBMC positively correlated with the inflammation area (linear fit; R2=0.91) and virus capsid protein VP1 (linear fit; R2=0.93) in the myocardial tissue. The results imply that iNKT might be used as a parameter for the ...

[1]  Wei Liu,et al.  Cross-regulation of T regulatory-cell response after coxsackievirus B3 infection by NKT and γδ T cells in the mouse. , 2013, The American journal of pathology.

[2]  S. Jonjić,et al.  The evolutionary arms race between NK cells and viruses: Who gets the short end of the stick? , 2013, European journal of immunology.

[3]  Vrajesh V. Parekh,et al.  Activated Invariant NKT Cells Control Central Nervous System Autoimmunity in a Mechanism That Involves Myeloid-Derived Suppressor Cells , 2013, The Journal of Immunology.

[4]  S. Huber,et al.  Slam haplotype 2 promotes NKT but suppresses Vγ4+ T-cell activation in coxsackievirus B3 infection leading to increased liver damage but reduced myocarditis. , 2013, The American journal of pathology.

[5]  M. Smyth,et al.  Transient Foxp3+ regulatory T‐cell depletion enhances therapeutic anticancer vaccination targeting the immune‐stimulatory properties of NKT cells , 2013, Immunology and cell biology.

[6]  J. Ge,et al.  Initial weight and virus dose: two factors affecting the onset of acute coxsackievirus B3 myocarditis in C57BL/6 mouse--a histopathology-based study. , 2013, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

[7]  D. Chang,et al.  Modulatory Function of Invariant Natural Killer T Cells in Systemic Lupus Erythematosus , 2012, Clinical & developmental immunology.

[8]  Ikuo Tsunoda,et al.  Regulatory T cells and Th17 cells in viral infections: implications for multiple sclerosis and myocarditis. , 2012, Future virology.

[9]  J. Ge,et al.  Blockade of interleukin-17A protects against coxsackievirus B3-induced myocarditis by increasing COX-2/PGE2 production in the heart. , 2012, FEMS immunology and medical microbiology.

[10]  P. Carmeliet,et al.  Thrombospondin-2 prevents cardiac injury and dysfunction in viral myocarditis through the activation of regulatory T-cells. , 2012, Cardiovascular research.

[11]  L. Cooper,et al.  Republished: Pathogenesis and diagnosis of myocarditis , 2012, Postgraduate Medical Journal.

[12]  L. Cooper,et al.  Update on myocarditis. , 2012, Journal of the American College of Cardiology.

[13]  C. Guzmán,et al.  NKT Cell Stimulation with α-Galactosylceramide Results in a Block of Th17 Differentiation after Intranasal Immunization in Mice , 2012, PloS one.

[14]  J. Ge,et al.  The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis. , 2011, Virology.

[15]  G. Qian,et al.  α‐Galactosylceramide protects mice from lethal Coxsackievirus B3 infection and subsequent myocarditis , 2010, Clinical and experimental immunology.

[16]  B. McManus,et al.  Regulating viral myocarditis: allografted regulatory T cells decrease immune infiltration and viral load. , 2010, Circulation.

[17]  Hyunji Lee,et al.  Natural killer T cells promote collagen-induced arthritis in DBA/1 mice. , 2009, Biochemical and biophysical research communications.

[18]  Hiroyasu Ito,et al.  Valpha14 NKT cells activated by alpha-galactosylceramide augment lipopolysaccharide-induced nitric oxide production in mouse intra-hepatic lymphocytes. , 2009, Biochemical and biophysical research communications.

[19]  Y. Ishii,et al.  Characterization of the immature dendritic cells and cytotoxic cells both expanded after activation of invariant NKT cells with alpha-galactosylceramide in vivo. , 2008, Biochemical and biophysical research communications.

[20]  M. Taniguchi,et al.  Methods for detection, isolation and culture of mouse and human invariant NKT cells , 2007, Nature Protocols.

[21]  S. Huber,et al.  Role of CD1d in Coxsackievirus B3-Induced Myocarditis 1 , 2003, The Journal of Immunology.

[22]  J. Mosnier,et al.  Enteroviral capsid protein VP1 is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy. , 2000, Circulation.