Intron recognition comes of AGe

The molecular basis for the consensus sequence at the 3' ends of introns in higher eukaryotes has now been elucidated. However, this discovery does not explain all aspects of 3' splice site selection.

[1]  R. Reed,et al.  Human homologs of yeast Prp16 and Prp17 reveal conservation of the mechanism for catalytic step II of pre‐mRNA splicing , 1998, The EMBO journal.

[2]  R. Reed,et al.  Protein components specifically associated with prespliceosome and spliceosome complexes. , 1992, Genes & development.

[3]  J. Valcárcel,et al.  Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG , 1999, Nature.

[4]  A. Krainer.  Eukaryotic mRNA processing , 1997 .

[5]  R. Reed,et al.  The organization of 3' splice-site sequences in mammalian introns. , 1989, Genes & development.

[6]  R. Reed,et al.  The RNA splicing factor hSlu7 is required for correct 3′ splice-site choice , 1999, Nature.

[7]  M. Rosbash,et al.  Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicing , 1985, Nature.

[8]  N L Harris,et al.  Splice junctions, branch point sites, and exons: sequence statistics, identification, and applications to genome project. , 1990, Methods in enzymology.

[9]  J. Valcárcel,et al.  Evidence for Substrate-Specific Requirement of the Splicing Factor U2AF35 and for Its Function after Polypyrimidine Tract Recognition by U2AF65 , 1999, Molecular and Cellular Biology.

[10]  T. Maniatis,et al.  The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. , 1996, Genes & development.

[11]  A. Krämer,et al.  The structure and function of proteins involved in mammalian pre-mRNA splicing. , 1996, Annual review of biochemistry.

[12]  J. G. Patton,et al.  A novel set of spliceosome‐associated proteins and the essential splicing factor PSF bind stably to pre‐mRNA prior to catalytic step II of the splicing reaction. , 1994, The EMBO journal.

[13]  A. Weiner,et al.  The conserved dinucleotide AG of the 3' splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors. , 1990, Gene.

[14]  M. Moore,et al.  Bimolecular exon ligation by the human spliceosome. , 1997, Science.

[15]  J. Valcárcel,et al.  Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. , 1995, Science.

[16]  Michael R. Green,et al.  Functional recognition of the 3′ splice site AG by the splicing factor U2AF35 , 1999, Nature.

[17]  C. H. Gross,et al.  Prp22, a DExH‐box RNA helicase, plays two distinct roles in yeast pre‐mRNA splicing , 1998, The EMBO journal.

[18]  C. Guthrie,et al.  Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. , 1999, Genes & development.

[19]  Thomas Blumenthal,et al.  Both subunits of U2AF recognize the 3′ splice site in Caenorhabditis elegans , 1999, Nature.