Research Status of Tissue Engineering of Endovascular Stent and Spring Ring

Tissue engineering in cerebral vessels refers to fusion of bioengineering, cytobiology, molecular biology and traditional endovascular treatment technology. This technology takes spring ring and stent as mechanical carrier and takes biodegradable material or virus as biological carrier, and carries in-vitro prepared protein, cells, genes and attachment proteins or cell factors to treat corresponding cerebrovascular disease (vessel occurance, ischemia and ischemia etc.) with the help of conventional catheter technology. This technology has such advantages as high biocompatibility, growth, plasticity and no damage to body. The lesion part treated by endovascular tissue engineering will be closer to normal tissue form and recovery of physiological functions.

[1]  D. Dichek,et al.  Enhancement of the fibrinolytic activity of sheep endothelial cells by retroviral vector-mediated gene transfer. , 1991, Blood.

[2]  T. Tammela,et al.  Expansion and fixation properties of a new braided biodegradable urethral stent: an experimental study in the rabbit. , 2003, The Journal of urology.

[3]  I. Mikhailenko,et al.  LRP1 Protects the Vasculature by Regulating Levels of Connective Tissue Growth Factor and HtrA1 , 2013, Arteriosclerosis, thrombosis, and vascular biology.

[4]  H. Matsubara,et al.  Bone Marrow Monocyte Lineage Cells Adhere on Injured Endothelium in a Monocyte Chemoattractant Protein-1–Dependent Manner and Accelerate Reendothelialization as Endothelial Progenitor Cells , 2003, Circulation research.

[5]  R. Thorpe,et al.  A systematic approach to the establishment and characterization of endothelial progenitor cells for gene therapy. , 2013, Human gene therapy methods.

[6]  S. Diamond,et al.  Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model. , 2001, AJNR. American journal of neuroradiology.

[7]  Ping Wang,et al.  Low‐molecular‐weight fibroblast growth factor 2 attenuates hepatic fibrosis by epigenetic down‐regulation of Delta‐like1 , 2015, Hepatology.

[8]  S. Achatz,et al.  Vascular gene delivery of anticoagulants by transplantation of retrovirally-transduced endothelial progenitor cells. , 2003, Cardiovascular research.

[9]  Deepak Pandiar,et al.  Immunohistochemical expression of CD34 and basic fibroblast growth factor (bFGF) in oral submucous fibrosis , 2014, Journal of oral and maxillofacial pathology : JOMFP.

[10]  D. Linch,et al.  Transmigration of CD 34 1 Cells Across Specialized and Nonspecialized Endothelium Requires Prior Activation by Growth Factors and Is Mediated by PECAM-1 ( CD 31 ) By , 1998 .

[11]  S. Hsu,et al.  Mediation of the migration of endothelial cells and fibroblasts on polyurethane nanocomposites by the activation of integrin-focal adhesion kinase signaling. , 2012, Journal of biomedical materials research. Part A.

[12]  J. Wardlaw,et al.  Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial , 2011, The Lancet.