Tracking sustained oscillations in delay model oregonators

Sustained oscillations occur in many biological organisms and some chemical reactions. Belousov-Zhabotinskii (BZ) reaction is one these chemical oscillators, however, since its oscillatory behaviour is analogous to ones in observed in many biological systems, BZ reaction is often considered as a prototype for bio-chemical oscillators. In this work, by considering a delay model of the Oregonator, which covers the sustained oscillatory mechanism of BZ reaction, we presented some qualitative results in order to find a domain in parameter space that ensures the presence of sustained oscillations. By using the unique positive equilibrium of the model, some necessary and/or sufficient results presented to describe its asymptotic behaviour. Then, by using these results, some numerical computations are presented to describe an oscillatory occurence domain in the parameter space.

[1]  J. Keizer Biochemical Oscillations and Cellular Rhythms: The molecular bases of periodic and chaotic behaviour, by Albert Goldbeter , 1998 .

[2]  J. Tyson Relaxation oscillations in the revised Oregonator , 1984 .

[3]  Frank Allgöwer,et al.  Stability Analysis for Time-Delay Systems using Rekasius's Substitution and Sum of Squares , 2006, Proceedings of the 45th IEEE Conference on Decision and Control.

[4]  A. Goldbeter Computational approaches to cellular rhythms , 2002, Nature.

[5]  Irving R. Epstein,et al.  Differential delay equations in chemical kinetics. Nonlinear models: The cross‐shaped phase diagram and the Oregonator , 1991 .

[6]  G. Nicolis,et al.  Chemical instabilities and sustained oscillations. , 1971, Journal of theoretical biology.

[7]  Silviu-Iulian Niculescu,et al.  Further remarks on delay dynamics in Oregonator models , 2016, 2016 12th IEEE International Conference on Control and Automation (ICCA).

[8]  M. Roussel The Use of Delay Differential Equations in Chemical Kinetics , 1996 .

[9]  S. Hastings,et al.  The Existence of Oscillatory Solutions in the Field–Noyes Model for the Belousov–Zhabotinskii Reaction , 1975 .

[10]  J. Tyson Analytic representation of oscillations, excitability, and traveling waves in a realistic model of the Belousov–Zhabotinskii reaction , 1977 .

[11]  J. Tyson,et al.  Design principles of biochemical oscillators , 2008, Nature Reviews Molecular Cell Biology.

[12]  S. Niculescu Delay Effects on Stability: A Robust Control Approach , 2001 .

[13]  G. Zames On the input-output stability of time-varying nonlinear feedback systems Part one: Conditions derived using concepts of loop gain, conicity, and positivity , 1966 .

[14]  K. Gopalsamy Stability and Oscillations in Delay Differential Equations of Population Dynamics , 1992 .

[15]  R. M. Noyes,et al.  Oscillations in chemical systems. IV. Limit cycle behavior in a model of a real chemical reaction , 1974 .

[16]  B. Goodwin Oscillatory behavior in enzymatic control processes. , 1965, Advances in enzyme regulation.

[17]  Dirk Roose,et al.  Numerical bifurcation analysis of delay differential equations using DDE-BIFTOOL , 2002, TOMS.