16α-OHE1, a novel oestrogen metabolite, attenuates dysfunction of left ventricle contractility via regulation of autophagy after myocardial ischemia and reperfusion.

[1]  J. Luna-Muñoz,et al.  Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators , 2022, Cells.

[2]  T. Maier,et al.  mTOR substrate phosphorylation in growth control , 2022, Cell.

[3]  Mei Tian,et al.  Autophagy regulates X-ray radiation-induced premature senescence through STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells , 2022, International journal of radiation biology.

[4]  M. Post,et al.  Autophagy is impaired in fetal hypoplastic lungs and rescued by administration of amniotic fluid stem cell extracellular vesicles , 2022, bioRxiv.

[5]  M. Masařík,et al.  Crosstalk between autophagy inhibitors and endosome-related secretory pathways: a challenge for autophagy-based treatment of solid cancers , 2021, Molecular cancer.

[6]  Zili Chen,et al.  AM1241 alleviates myocardial ischemia-reperfusion injury in rats by enhancing Pink1/Parkin-mediated autophagy. , 2021, Life sciences.

[7]  A. Bozcaarmutlu,et al.  Decreasing myocardial estrogen receptors and antioxidant activity may be responsible for increasing ischemia- and reperfusion-induced ventricular arrhythmia in older female rats. , 2021, Life sciences.

[8]  Lei Guo,et al.  17β-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes via the SIRT1-Mediated AMPK/mTOR Signaling Pathway , 2021, Frontiers in Endocrinology.

[9]  Zhiqiang Yu,et al.  Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK/mTOR/ULK1 signalling pathway. , 2020, Environment international.

[10]  M. Plebani,et al.  Clinical relevance of biological variation of cardiac troponins , 2020, Clinical chemistry and laboratory medicine.

[11]  J. Manson,et al.  Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women , 2020, Circulation.

[12]  H. Dobrzynski,et al.  Identification of Key Small Non‐Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node , 2020, Journal of the American Heart Association.

[13]  Wen Chen,et al.  Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy , 2020, Journal of advanced research.

[14]  Kai-Peng Yang,et al.  Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis , 2020, Bioscience reports.

[15]  D. Klionsky,et al.  Sex differences in autophagy-mediated diseases: toward precision medicine , 2020, Autophagy.

[16]  J. Manson,et al.  Isoflavone Intake and the Risk of Coronary Heart Disease in US Men and Women , 2020, Circulation.

[17]  M. Vila,et al.  Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease , 2020, Autophagy.

[18]  Adebayo Adekunle,et al.  Estrogen and Calcium Handing Proteins: New Discoveries and Mechanisms in Cardiovascular Diseases. , 2020, American journal of physiology. Heart and circulatory physiology.

[19]  Li Guan,et al.  AMPK/mTOR-mediated therapeutic effect of metformin on myocardial ischaemia reperfusion injury in diabetic rat , 2020, Acta cardiologica.

[20]  Z. Qin,et al.  Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway , 2019, Acta Pharmacologica Sinica.

[21]  L. Ouyang,et al.  Targeting autophagy-related protein kinases for potential therapeutic purpose , 2019, Acta pharmaceutica Sinica. B.

[22]  W. Lau,et al.  S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocytes Death in Response Ischemic/Reperfusion Injury. , 2019, Circulation.

[23]  S. Howlett,et al.  Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice , 2019, Biology of Sex Differences.

[24]  Xianhe Lin,et al.  mTOR and Beclin1: Two key autophagy‐related molecules and their roles in myocardial ischemia/reperfusion injury , 2019, Journal of cellular physiology.

[25]  Jiahai Shi,et al.  Involvement of Nrf2 in myocardial ischemia and reperfusion injury. , 2019, International journal of biological macromolecules.

[26]  I. Sahin,et al.  Biomarkers in acute myocardial infarction: current perspectives , 2019, Vascular health and risk management.

[27]  A. Abbate,et al.  Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury. , 2018, American journal of physiology. Heart and circulatory physiology.

[28]  Chiu-fen Yang.  Clinical manifestations and basic mechanisms of myocardial ischemia/reperfusion injury , 2018, Ci ji yi xue za zhi = Tzu-chi medical journal.

[29]  Jin Xiang,et al.  How does estrogen work on autophagy? , 2018, Autophagy.

[30]  Liu Yanhui,et al.  Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[31]  Z. Wang,et al.  Vaspin alleviates myocardial ischaemia/reperfusion injury via activating autophagic flux and restoring lysosomal function. , 2018, Biochemical and biophysical research communications.

[32]  D. Klionsky,et al.  AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc – Activity , 2018, Current Biology.

[33]  Hong Jiang,et al.  Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury , 2018, International journal of molecular medicine.

[34]  Q. Ma,et al.  Melatonin Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy Via an AMPK/mTOR Signaling Pathway , 2018, Cellular Physiology and Biochemistry.

[35]  Shuxia Fan,et al.  Ginsenoside Rg1 protects cardiomyocytes from hypoxia-induced injury through the PI3K/AKT/mTOR pathway. , 2018, Die Pharmazie.

[36]  Seema Patel,et al.  Estrogen: The necessary evil for human health, and ways to tame it. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[37]  S. Koblar,et al.  Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser396) and (Ser262) via AMPK but not mTOR signaling pathway , 2018, Molecular and Cellular Neuroscience.

[38]  S. Cadenas.  ROS and redox signaling in myocardial ischemia-reperfusion injury and cardioprotection. , 2018, Free radical biology & medicine.

[39]  J. Eikelboom,et al.  A Test in Context: D-Dimer. , 2017, Journal of the American College of Cardiology.

[40]  Michael S Marber,et al.  Cardiac troponins: from myocardial infarction to chronic disease , 2017, Cardiovascular research.

[41]  L. Galluzzi,et al.  Autophagy and Mitophagy in Cardiovascular Disease. , 2017, Circulation research.

[42]  Lorenzo Galluzzi,et al.  Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles , 2017, Nature Reviews Drug Discovery.

[43]  Dan Yang,et al.  LFG-500, a newly synthesized flavonoid, induces apoptosis in human ovarian carcinoma SKOV3 cells with involvement of the reactive oxygen species-mitochondria pathway , 2017, Experimental and therapeutic medicine.

[44]  Jianhong Gu,et al.  The ER stress regulator Bip mediates cadmium-induced autophagy and neuronal senescence , 2016, Scientific Reports.

[45]  I. Spasojević,et al.  Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury , 2016, Oxidative medicine and cellular longevity.

[46]  C. Matthews,et al.  Epidemiologic studies of estrogen metabolism and breast cancer , 2015, Steroids.

[47]  B. Johnston,et al.  The Ovariectomized Rat as a Model for Studying Alveolar Bone Loss in Postmenopausal Women , 2015, BioMed research international.

[48]  F. Van de Werf,et al.  Evolving therapies for myocardial ischemia/reperfusion injury. , 2015, Journal of the American College of Cardiology.

[49]  Kelvin Sze-Yin Leung,et al.  LC–MS/MS in the routine clinical laboratory: has its time come? , 2014, Analytical and Bioanalytical Chemistry.

[50]  Andreas Krämer,et al.  Causal analysis approaches in Ingenuity Pathway Analysis , 2013, Bioinform..

[51]  P. Arias-Loza,et al.  Estrogen and estrogen receptors in cardiovascular oxidative stress , 2013, Pflügers Archiv - European Journal of Physiology.

[52]  T. Eckle,et al.  Myocardial Ischemia Reperfusion Injury , 2012, Seminars in cardiothoracic and vascular anesthesia.

[53]  T. Eckle,et al.  Ischemia and reperfusion—from mechanism to translation , 2011, Nature Medicine.

[54]  S. Wesselborg,et al.  Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks , 2011, Molecular and Cellular Biology.

[55]  R. Gottlieb,et al.  Review: Autophagy: Definition, Molecular Machinery, and Potential Role in Myocardial Ischemia-Reperfusion Injury , 2010, Journal of cardiovascular pharmacology and therapeutics.

[56]  Sandra Barth,et al.  Autophagy: cellular and molecular mechanisms , 2010, The Journal of pathology.

[57]  D. Klionsky,et al.  Regulation mechanisms and signaling pathways of autophagy. , 2009, Annual review of genetics.

[58]  Satoru Kobayashi,et al.  Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death* , 2009, The Journal of Biological Chemistry.

[59]  K. Otsu,et al.  Discovery of Atg5/Atg7-independent alternative macroautophagy , 2009, Nature.

[60]  Shufeng Zhou.  Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4. , 2008, Current drug metabolism.

[61]  L. Delbridge,et al.  The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy. , 2008, American journal of physiology. Heart and circulatory physiology.

[62]  J. M. Roman,et al.  Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry. , 2007, Analytical chemistry.

[63]  T. Asano,et al.  Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy , 2007, Circulation research.

[64]  Lubo Zhang,et al.  Gender Differences in Cardioprotection against Ischemia/Reperfusion Injury in Adult Rat Hearts: Focus on Akt and Protein Kinase C Signaling , 2005, Journal of Pharmacology and Experimental Therapeutics.

[65]  M. Nakajima,et al.  Cytochrome P450-mediated Metabolism of Estrogens and Its Regulation in Human , 2004 .

[66]  Francesco Scaravilli,et al.  Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease , 2004, Nature Genetics.

[67]  C. Pasqualin,et al.  Molecular and functional characterization of the mouse intrinsic cardiac nervous system , 2022 .