Mitochondrial function as a therapeutic target in heart failure
暂无分享,去创建一个
G. Filippatos | J. Cleland | M. Gheorghiade | S. Anker | J. Butler | B. Pitt | B. Pieske | A. Voors | S. Shaikh | H. Sabbah | David A. Brown | W. Colucci | B. Stauffer | S. Greene | Justin B. Perry | Mitchell E. Allen
[1] Quincy A. Hathaway,et al. Role of microRNA in metabolic shift during heart failure. , 2017, American journal of physiology. Heart and circulatory physiology.
[2] Javed Butler,et al. Cardiac Myosin Activators in Systolic Heart Failure: More Friend than Foe? , 2016, Current Cardiology Reports.
[3] B. Pieske,et al. Novel pathomechanisms of cardiomyocyte dysfunction in a model of heart failure with preserved ejection fraction , 2016, European journal of heart failure.
[4] D. Bernstein,et al. Mitochondrial remodeling: Rearranging, recycling, and reprogramming. , 2016, Cell calcium.
[5] M. Söderström,et al. Intramyocardial injection of SERCA2a‐expressing lentivirus improves myocardial function in doxorubicin‐induced heart failure , 2016, The journal of gene medicine.
[6] Alan Brown,et al. Organization and Regulation of Mitochondrial Protein Synthesis. , 2016, Annual review of biochemistry.
[7] C. Hoppel,et al. Mitochondrial Metabolism in Aging Heart. , 2016, Circulation research.
[8] Sanjiv J. Shah,et al. Developing New Treatments for Heart Failure: Focus on the Heart , 2016, Circulation. Heart failure.
[9] Q. Lv,et al. Improved systolic function of rat cardiocytes during heart failure by overexpression of SERCA2a. , 2016, European review for medical and pharmacological sciences.
[10] Piotr Ponikowski,et al. Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF Study. , 2016, Journal of the American College of Cardiology.
[11] Akshay S. Desai,et al. Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial , 2016, The Lancet.
[12] D. Bers,et al. Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore Openings. , 2016, Circulation research.
[13] K. Margulies,et al. Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure , 2016, Circulation.
[14] R. Tian,et al. Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure? , 2016, Circulation.
[15] Souheila Hachem,et al. Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure , 2016, Circulation. Heart failure.
[16] C. Piantadosi,et al. Mitochondrial Quality Control as a Therapeutic Target , 2016, Pharmacological Reviews.
[17] Edgar B. Smith,et al. An Update and Review , 2016 .
[18] B. O’Rourke,et al. Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytes. , 2016, Cardiovascular research.
[19] Xianlin Han,et al. Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart. , 2015, Life sciences.
[20] W. Frontera,et al. Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats , 2015, Oncotarget.
[21] I. Édes,et al. The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat , 2015, British journal of pharmacology.
[22] P. Lipp,et al. Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure. , 2015, Cell metabolism.
[23] Andrew J. Sauer,et al. "Targeting the Heart" in Heart Failure: Myocardial Recovery in Heart Failure With Reduced Ejection Fraction. , 2015, JACC. Heart failure.
[24] J. Dyck,et al. Therapeutic potential of resveratrol in heart failure , 2015, Annals of the New York Academy of Sciences.
[25] A. Gavazzi,et al. Heart failure at the crossroads: moving beyond blaming stakeholders to targeting the heart , 2015, European journal of heart failure.
[26] C. D. dos Remedios,et al. Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. , 2015, Journal of molecular and cellular cardiology.
[27] G. Lopaschuk,et al. Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets. , 2015, Current pharmaceutical design.
[28] M. Vaduganathan,et al. Contemporary Drug Development in Heart Failure: Call for Hemodynamically Neutral Therapies. , 2015, Circulation. Heart failure.
[29] T. Myrmel,et al. Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity , 2015, Circulation. Heart failure.
[30] L. Kirshenbaum,et al. Mitochondrial dynamics: Orchestrating the journey to advanced age. , 2015, Journal of molecular and cellular cardiology.
[31] G. Dorn,et al. How mitochondrial dynamism orchestrates mitophagy. , 2015, Circulation research.
[32] J. C. Belmonte,et al. Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing , 2015, Cell.
[33] D. DeMets,et al. Cardiovascular drug development: is it dead or just hibernating? , 2015, Journal of the American College of Cardiology.
[34] R. Hajjar,et al. Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatment. , 2015, Cell metabolism.
[35] G. Dorn,et al. The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. , 2015, Circulation research.
[36] A. Shah,et al. Mitochondrial dysfunction and oxidative stress in CHF , 2014 .
[37] B. Greenberg,et al. Safety and tolerability of omecamtiv mecarbil during exercise in patients with ischemic cardiomyopathy and angina. , 2015, JACC. Heart failure.
[38] B. Polster,et al. Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier? , 2015, Journal of Bioenergetics and Biomembranes.
[39] J. Marín-García,et al. Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart , 2015, Heart Failure Reviews.
[40] W. Frontera,et al. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. , 2014, Journal of molecular and cellular cardiology.
[41] F. Rosenfeldt,et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. , 2014, JACC. Heart failure.
[42] H. Szeto,et al. Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity , 2014, Clinical pharmacology and therapeutics.
[43] Edward T Chouchani,et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS , 2014, Nature.
[44] Rick B. Vega,et al. Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart: A Multisystems Approach , 2014, Circulation. Heart failure.
[45] E. Anderson,et al. The “Goldilocks Zone” from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle , 2014, Front. Physiol..
[46] C. Sucharov,et al. Dysregulation of cardiolipin biosynthesis in pediatric heart failure. , 2014, Journal of molecular and cellular cardiology.
[47] L. Lerman,et al. Mitochondrial protection restores renal function in swine atherosclerotic renovascular disease. , 2014, Cardiovascular research.
[48] M. Sánchez-Niño,et al. Mitochondria-targeted therapies for acute kidney injury , 2014, Expert Reviews in Molecular Medicine.
[49] M. Gheorghiade,et al. Molecular and Cellular Basis of Viable Dysfunctional Myocardium , 2014, Circulation. Heart failure.
[50] C. Baines,et al. A new twist on an old idea part 2: cyclosporine preserves normal mitochondrial but not cardiomyocyte function in mini‐swine with compensated heart failure , 2014, Physiological reports.
[51] G. Dorn,et al. Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy , 2014, Circulation research.
[52] V. Giorgio,et al. Channel Formation by Yeast F-ATP Synthase and the Role of Dimerization in the Mitochondrial Permeability Transition*♦ , 2014, The Journal of Biological Chemistry.
[53] Ping Chen,et al. Catechin ameliorates cardiac dysfunction in rats with chronic heart failure by regulating the balance between Th17 and Treg cells , 2014, Inflammation Research.
[54] H. Szeto,et al. Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis , 2014, British journal of pharmacology.
[55] G. Lopaschuk,et al. Malonyl CoA: A promising target for the treatment of cardiac disease , 2014, IUBMB life.
[56] L. Liaudet,et al. Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity , 2014, Heart Failure Reviews.
[57] L. Lerman,et al. Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension , 2014, Journal of hypertension.
[58] P. Neufer,et al. Reduction of Early Reperfusion Injury With the Mitochondria-Targeting Peptide Bendavia , 2014, Journal of cardiovascular pharmacology and therapeutics.
[59] L. Kirshenbaum,et al. Regulation of mitochondrial dynamics and cell fate. , 2014, Circulation journal : official journal of the Japanese Circulation Society.
[60] S. Shaikh,et al. Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia/reperfusion injury. , 2013, Pharmacology & therapeutics.
[61] R. E. Hughes,et al. Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. , 2013, Free radical biology & medicine.
[62] M. L. Genova,et al. Mitochondrial respiratory supercomplex association limits production of reactive oxygen species from complex I. , 2013, Antioxidants & redox signaling.
[63] M. Drazner,et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. , 2013, Journal of the American College of Cardiology.
[64] G. Perkins,et al. (-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients. , 2013, International journal of cardiology.
[65] T. Marwick,et al. Effect of If-channel inhibition on hemodynamic status and exercise tolerance in heart failure with preserved ejection fraction: a randomized trial. , 2013, Journal of the American College of Cardiology.
[66] Michael P. Siegel,et al. Mitochondrial‐targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice , 2013, Aging cell.
[67] Torsten Doenst,et al. Cardiac Metabolism in Heart Failure: Implications Beyond ATP Production , 2013, Circulation research.
[68] C. Moraes,et al. Specific elimination of mutant mitochondrial genomes in patient–derived cells by mitoTALENs , 2013, Nature Medicine.
[69] Miyuki Sato,et al. Maternal inheritance of mitochondrial DNA by diverse mechanisms to eliminate paternal mitochondrial DNA. , 2013, Biochimica et biophysica acta.
[70] H. Szeto,et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. , 2013, Journal of the American Society of Nephrology : JASN.
[71] S. Ghaffari,et al. The effect of prethrombolytic cyclosporine-A injection on clinical outcome of acute anterior ST-elevation myocardial infarction. , 2013, Cardiovascular therapeutics.
[72] C. López-Otín,et al. Supercomplex Assembly Determines Electron Flux in the Mitochondrial Electron Transport Chain , 2013, Science.
[73] Rick B. Vega,et al. Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart. , 2013, Biochimica et biophysica acta.
[74] David A. Brown,et al. Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria. , 2013, Cardiovascular research.
[75] V. Giorgio,et al. Dimers of mitochondrial ATP synthase form the permeability transition pore , 2013, Proceedings of the National Academy of Sciences.
[76] M. Gheorghiade,et al. Mitochondria as a therapeutic target in heart failure. , 2013, Journal of the American College of Cardiology.
[77] C. Hoppel,et al. Mitochondria in cardiac hypertrophy and heart failure. , 2013, Journal of molecular and cellular cardiology.
[78] T. Shirasawa,et al. Antioxidants Improve the Phenotypes of Dilated Cardiomyopathy and Muscle Fatigue in Mitochondrial Superoxide Dismutase-Deficient Mice , 2013, Molecules.
[79] D. Egli,et al. Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants , 2012, Nature.
[80] M. MacCoss,et al. Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides , 2012, Circulation. Heart failure.
[81] Hsin-Chieh Yeh,et al. Effect of the 2011 vs 2003 duty hour regulation-compliant models on sleep duration, trainee education, and continuity of patient care among internal medicine house staff: a randomized trial. , 2013, JAMA internal medicine.
[82] Å. Gustafsson,et al. Mitochondrial autophagy--an essential quality control mechanism for myocardial homeostasis. , 2013, Circulation journal : official journal of the Japanese Circulation Society.
[83] K. McDonald,et al. Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O2 balance and diastolic function. , 2013, Journal of applied physiology.
[84] Biykem Bozkurt,et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. , 2013, Circulation.
[85] C. Hoppel,et al. Mitochondrial dysfunction in heart failure , 2013, Heart Failure Reviews.
[86] R. Hajjar,et al. Altered sarcoplasmic reticulum calcium cycling—targets for heart failure therapy , 2012, Nature Reviews Cardiology.
[87] S. Dimauro,et al. Human mitochondrial DNA: roles of inherited and somatic mutations , 2012, Nature Reviews Genetics.
[88] D. Atar,et al. Rationale and Design of the ‘MITOCARE’ Study: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRO40303 for the Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction , 2012, Cardiology.
[89] G. Porter,et al. Mitochondria as a Drug Target in Ischemic Heart Disease and Cardiomyopathy , 2012, Circulation research.
[90] Robert W. Taylor,et al. Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and management , 2012, European heart journal.
[91] J. Gorman,et al. Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria-Targeting Cytoprotective Peptide , 2012, Journal of the American Heart Association.
[92] David A. Brown,et al. Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. , 2012, Journal of molecular and cellular cardiology.
[93] P. Barboni,et al. Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy. , 2012, Archives of neurology.
[94] A. Garnier,et al. Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcumin. , 2012, American journal of physiology. Heart and circulatory physiology.
[95] Robert N. Doughty,et al. The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis. , 2011, European heart journal.
[96] K. McDonald,et al. Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O 2 balance and diastolic function , 2012 .
[97] D. Atar,et al. Rationale and Design of the 'MITOCARE' Study: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRO40303 for the Reduction of Reperfusion Injury in Patients Undergoing Percutaneous Coronary Intervention for Acute Myocardial Infarction , 2012 .
[98] K. Magyara,et al. Cardioprotection by resveratrol : A human clinical trial in patients with stable coronary artery disease , 2012 .
[99] H. Antretter,et al. Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. , 2011, The international journal of biochemistry & cell biology.
[100] C. Hoppel,et al. Cardiac mitochondria in heart failure: normal cardiolipin profile and increased threonine phosphorylation of complex IV. , 2011, Biochimica et biophysica acta.
[101] S. Powers,et al. Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophy. , 2011, Journal of applied physiology.
[102] S. Fröhling,et al. Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study. , 2011, Journal of the American College of Cardiology.
[103] David A. Brown,et al. Exercise-induced cardiac preconditioning: how exercise protects your achy-breaky heart. , 2011, Journal of applied physiology.
[104] J. Cleland,et al. The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial , 2011, The Lancet.
[105] Wendy Keung,et al. Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart. , 2011, Biochimica et biophysica acta.
[106] S. Powers,et al. Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness* , 2011, Critical care medicine.
[107] P. Rabinovitch,et al. Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathy. , 2011, Journal of the American College of Cardiology.
[108] T. Miksanek. The Sublime Engine: A Biography of the Human Heart , 2011 .
[109] B. Chernyak,et al. Novel Mitochondria-Targeted Antioxidants: Plastoquinone Conjugated with Cationic Plant Alkaloids Berberine and Palmatine , 2011, Pharmaceutical Research.
[110] H. Szeto,et al. Novel Therapies Targeting Inner Mitochondrial Membrane—From Discovery to Clinical Development , 2011, Pharmaceutical Research.
[111] H. Szeto,et al. Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injury. , 2011, Journal of the American Society of Nephrology : JASN.
[112] Angelo Auricchio,et al. What are the costs of heart failure? , 2011, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.
[113] H. Westerblad,et al. Mitochondrial production of reactive oxygen species contributes to the β‐adrenergic stimulation of mouse cardiomycytes , 2011, The Journal of physiology.
[114] J. Starnes,et al. Effect of N-2-mercaptopropionyl glycine on exercise-induced cardiac adaptations. , 2011, American journal of physiology. Regulatory, integrative and comparative physiology.
[115] D. Cox,et al. Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure , 2011, Science.
[116] S. Walrand,et al. Chronic formoterol administration reduces cardiac mitochondrial protein synthesis and oxidative capacity in mice. , 2011, International journal of cardiology.
[117] Z. Bosnjak,et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. , 2010, Free radical biology & medicine.
[118] B. O’Rourke,et al. Role of mitochondrial dysfunction in cardiac glycoside toxicity. , 2010, Journal of molecular and cellular cardiology.
[119] B. O’Rourke,et al. Cardiac mitochondria and arrhythmias. , 2010, Cardiovascular research.
[120] J. McMurray,et al. Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure). , 2010, Journal of the American College of Cardiology.
[121] S. Cortassa,et al. Redox-optimized ROS balance: a unifying hypothesis. , 2010, Biochimica et biophysica acta.
[122] M. Aon,et al. Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization. , 2010, Journal of molecular and cellular cardiology.
[123] D. Harrison,et al. Therapeutic targeting of mitochondrial superoxide in hypertension , 2010, Circulation research.
[124] P. Croisille,et al. Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarction. , 2010, Journal of the American College of Cardiology.
[125] Min Zhang,et al. NADPH oxidases and cardiac remodelling , 2010, Heart Failure Reviews.
[126] M. Gheorghiade,et al. Enhancing the metabolic substrate: PPAR-alpha agonists in heart failure , 2010, Heart Failure Reviews.
[127] V. Shoshan-Barmatz,et al. NCLX is an essential component of mitochondrial Na+/Ca2+ exchange , 2009, Proceedings of the National Academy of Sciences.
[128] W. Cascio,et al. 'Leaky' ryanodine receptors and sudden cardiac death. , 2009, Cardiovascular research.
[129] Dmitry Terentyev,et al. Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death. , 2009, Cardiovascular research.
[130] Javed Butler,et al. The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. , 2009, Journal of the American College of Cardiology.
[131] P. Pasdois,et al. The role of the mitochondrial permeability transition pore in heart disease. , 2009, Biochimica et biophysica acta.
[132] R. Balaban. The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac work. , 2009, Biochimica et biophysica acta.
[133] T. Kaneko,et al. Antioxidant, EUK-8, prevents murine dilated cardiomyopathy. , 2009, Circulation journal : official journal of the Japanese Circulation Society.
[134] Manuela G. López,et al. Mitochondrial Na+/Ca2+-Exchanger Blocker CGP37157 Protects against Chromaffin Cell Death Elicited by Veratridine , 2009, Journal of Pharmacology and Experimental Therapeutics.
[135] G. Hatch,et al. Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure , 2009, Journal of Lipid Research.
[136] A. Dominiczak,et al. Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy , 2009, Hypertension.
[137] A. Henning,et al. Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency. , 2009, Journal of the American College of Cardiology.
[138] Michael V. Cohen,et al. Why do we still not have cardioprotective drugs? , 2009, Circulation journal : official journal of the Japanese Circulation Society.
[139] C. Baines. The molecular composition of the mitochondrial permeability transition pore. , 2009, Journal of molecular and cellular cardiology.
[140] E. Griffiths. Mitochondrial calcium transport in the heart: physiological and pathological roles. , 2009, Journal of molecular and cellular cardiology.
[141] R. Balaban. Domestication of the cardiac mitochondrion for energy conversion. , 2009, Journal of molecular and cellular cardiology.
[142] Michael Stumvoll,et al. Antioxidants prevent health-promoting effects of physical exercise in humans , 2009, Proceedings of the National Academy of Sciences.
[143] L. A. Obukhova,et al. An attempt to prevent senescence: a mitochondrial approach. , 2009, Biochimica et biophysica acta.
[144] Daniel A Beard,et al. Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism , 2009, Proceedings of the National Academy of Sciences.
[145] W. Kraus,et al. Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. , 2009, JAMA.
[146] W. Kraus,et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. , 2009, JAMA.
[147] E. Lesnefsky,et al. Cardiolipin Remodeling in the Heart , 2009, Journal of cardiovascular pharmacology.
[148] P. Neufer,et al. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. , 2009, The Journal of clinical investigation.
[149] Matthew Gittinger,et al. Heart failure enhances susceptibility to arrhythmogenic cardiac alternans. , 2009, Heart rhythm.
[150] S. Sihag,et al. PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. , 2009, Journal of molecular and cellular cardiology.
[151] Minnie Sarwal,et al. Calcineurin Inhibitor Nephrotoxicity , 2012 .
[152] Michael P. Murphy,et al. How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.
[153] William T. Abraham,et al. Focused Update : ACCF / AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults , 2013 .
[154] Richard Neutze,et al. Opening and closing the metabolite gate , 2008, Proceedings of the National Academy of Sciences.
[155] J. Trnka,et al. Mitochondria‐Targeted Antioxidants in the Treatment of Disease , 2008, Annals of the New York Academy of Sciences.
[156] J. Enríquez,et al. Respiratory active mitochondrial supercomplexes. , 2008, Molecular cell.
[157] M. Aon,et al. Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts. , 2008, Journal of molecular and cellular cardiology.
[158] C. Frampton,et al. Coenzyme Q10: an independent predictor of mortality in chronic heart failure. , 2008, Journal of the American College of Cardiology.
[159] William Stanley,et al. Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation , 2008, Cardiovascular research.
[160] P. Scifo,et al. Impaired left ventricular energy metabolism in patients with hypertrophic cardiomyopathy is related to the extension of fibrosis at delayed gadolinium-enhanced magnetic resonance imaging , 2008, Heart.
[161] Pierre Croisille,et al. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. , 2008, The New England journal of medicine.
[162] R. Hajjar,et al. The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases , 2008, Nature Clinical Practice Cardiovascular Medicine.
[163] M. Murphy,et al. Targeting lipophilic cations to mitochondria. , 2008, Biochimica et biophysica acta.
[164] M. Frenneaux,et al. Reduced in vivo skeletal muscle oxygen consumption in patients with chronic heart failure—A study using Near Infrared Spectrophotometry (NIRS) , 2008, European journal of heart failure.
[165] E. Murphy,et al. Ion transport and energetics during cell death and protection. , 2008, Physiology.
[166] E. Murphy,et al. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. , 2008, Physiological reviews.
[167] A. Munnich,et al. Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications. , 2008, Blood.
[168] H. Szeto. Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injury. , 2008, Antioxidants & redox signaling.
[169] C. Frampton,et al. Coenzyme Q 10 An Independent Predictor of Mortality in Chronic Heart Failure , 2008 .
[170] C. Frampton,et al. An Independent Predictor of Mortality in Chronic Heart Failure , 2008 .
[171] David A. Brown,et al. Perspectives in innate and acquired cardioprotection: cardioprotection acquired through exercise. , 2007, Journal of applied physiology.
[172] Robert W. Taylor,et al. Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies. , 2007, Journal of the American College of Cardiology.
[173] A. Cipriani,et al. What is an individual patient data meta-analysis? , 2007, Epidemiologia e Psichiatria Sociale.
[174] W. Craigen,et al. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death , 2007, Nature Cell Biology.
[175] Yasuhide Watanabe,et al. Protein kinase A catalytic subunit alters cardiac mitochondrial redox state and membrane potential via the formation of reactive oxygen species. , 2007, Circulation journal : official journal of the Japanese Circulation Society.
[176] H. Sabbah,et al. Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure. , 2007, Journal of molecular and cellular cardiology.
[177] G. Sparagna,et al. Role of cardiolipin alterations in mitochondrial dysfunction and disease. , 2007, American journal of physiology. Cell physiology.
[178] David A. Brown,et al. Cardioprotection Acquired Through Exercise , 2007 .
[179] T. Nozawa,et al. Influence of β-Adrenoceptor Blockade on the Myocardial Accumulation of Fatty Acid Tracer and Its Intracellular Metabolism in the Heart After Ischemia-Reperfusion Injury , 2006 .
[180] Robert G. Weiss,et al. Altered Creatine Kinase Adenosine Triphosphate Kinetics in Failing Hypertrophied Human Myocardium , 2006, Circulation.
[181] P. Doevendans,et al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. , 2006, Journal of the American College of Cardiology.
[182] Brian O'Rourke,et al. Elevated Cytosolic Na+ Decreases Mitochondrial Ca2+ Uptake During Excitation–Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes , 2006, Circulation research.
[183] B. Menon,et al. Expression of the cytoplasmic domain of β1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway , 2006, Basic Research in Cardiology.
[184] S. Sollott,et al. Mitochondrial ROS-induced ROS release: an update and review. , 2006, Biochimica et biophysica acta.
[185] Laura C. Greaves,et al. Mitochondrial DNA mutations in human disease , 2006, IUBMB life.
[186] Arantxa González,et al. Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart disease. , 2006, Cardiovascular research.
[187] S. Cortassa,et al. Mitochondrial criticality: a new concept at the turning point of life or death. , 2006, Biochimica et biophysica acta.
[188] H. Sabbah,et al. Inhibition of Mitochondrial Permeability Transition Pores by Cyclosporine A Improves Cytochrome c Oxidase Function and Increases Rate of ATP Synthesis in Failing Cardiomyocytes , 2005, Heart Failure Reviews.
[189] M. Chandler,et al. Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemia. , 2005, American journal of physiology. Heart and circulatory physiology.
[190] J. Ornato,et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult—Summary Article , 2005 .
[191] D. Feldman,et al. Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failure , 2005, Nature Clinical Practice Cardiovascular Medicine.
[192] M David Tilson,et al. The polymorphonuclear leukocyte and the abdominal aortic aneurysm: a neglected cell type and a neglected disease. , 2005, Circulation.
[193] William C Stanley,et al. Myocardial substrate metabolism in the normal and failing heart. , 2005, Physiological reviews.
[194] Jeffrey Robbins,et al. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death , 2005, Nature.
[195] Paul A Bottomley,et al. ATP flux through creatine kinase in the normal, stressed, and failing human heart. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[196] H. Shimomura,et al. Effects of edaravone on reperfusion injury in patients with acute myocardial infarction. , 2004, The American journal of cardiology.
[197] M. Chandler,et al. Malonyl Coenzyme A Decarboxylase Inhibition Protects the Ischemic Heart by Inhibiting Fatty Acid Oxidation and Stimulating Glucose Oxidation , 2004, Circulation research.
[198] C. Bruno,et al. Respiratory complex III is required to maintain complex I in mammalian mitochondria. , 2004, Molecular cell.
[199] A. Garnier,et al. Energy metabolism in heart failure , 2004, The Journal of physiology.
[200] S. Javadov,et al. Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotection. , 2004, Cardiovascular research.
[201] Dean P. Jones,et al. The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore , 2004, Nature.
[202] D. Kelly,et al. Gene Regulatory Mechanisms Governing Energy Metabolism during Cardiac Hypertrophic Growth , 2002, Heart Failure Reviews.
[203] A. Munnich,et al. Dramatic improvement in mitochondrial cardiomyopathy following treatment with idebenone , 2001, Journal of Inherited Metabolic Disease.
[204] R. Starling,et al. Human myocardial ATP content and in vivo contractile function , 1998, Molecular and Cellular Biochemistry.
[205] Kathy Pfeiffer,et al. Cardiolipin Stabilizes Respiratory Chain Supercomplexes* , 2003, Journal of Biological Chemistry.
[206] David A. Brown,et al. Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart. , 2003, Journal of applied physiology.
[207] A. Blamire,et al. Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy. , 2003, Journal of the American College of Cardiology.
[208] S. Houser,et al. Sodium and the heart: a hidden key factor in cardiac regulation. , 2003, Cardiovascular research.
[209] S. Houser,et al. [Na+]i handling in the failing human heart. , 2003, Cardiovascular research.
[210] D. Sawyer,et al. &bgr;-Adrenergic Receptor–Stimulated Apoptosis in Cardiac Myocytes Is Mediated by Reactive Oxygen Species/c-Jun NH2-Terminal Kinase–Dependent Activation of the Mitochondrial Pathway , 2003, Circulation research.
[211] P. Herrero,et al. Myocardial Fatty Acid Metabolism: Independent Predictor of Left Ventricular Mass in Hypertensive Heart Disease , 2003, Hypertension.
[212] Stefan Neubauer,et al. Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy. , 2002, Journal of the American College of Cardiology.
[213] R. Balaban. Cardiac energy metabolism homeostasis: role of cytosolic calcium. , 2002, Journal of molecular and cellular cardiology.
[214] H. Schägger. Respiratory chain supercomplexes of mitochondria and bacteria. , 2002, Biochimica et biophysica acta.
[215] Lars S. Maier,et al. Rate Dependence of [Na+]i and Contractility in Nonfailing and Failing Human Myocardium , 2002, Circulation.
[216] Donald M Bers,et al. Intracellular Na+ Concentration Is Elevated in Heart Failure But Na/K Pump Function Is Unchanged , 2002, Circulation.
[217] A. Terzic,et al. Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[218] A E Vercesi,et al. Mitochondrial permeability transition and oxidative stress , 2001, FEBS letters.
[219] D. Kang,et al. Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction , 2001, Circulation research.
[220] J. Saffitz,et al. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. , 2000, The Journal of clinical investigation.
[221] M. Brand. Uncoupling to survive? The role of mitochondrial inefficiency in ageing , 2000, Experimental Gerontology.
[222] W. Colucci,et al. p38 Mitogen-activated Protein Kinase Pathway Protects Adult Rat Ventricular Myocytes against β-Adrenergic Receptor-stimulated Apoptosis , 2000, The Journal of Biological Chemistry.
[223] A. Takeshita,et al. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium. , 2000, Circulation research.
[224] S. Neubauer,et al. [Cardiac energy metabolism in heart valve diseases with 31P MR spectroscopy]. , 2000, Der Radiologe.
[225] S. Yusuf,et al. Vitamin E supplementation and cardiovascular events in high-risk patients. , 2000, The New England journal of medicine.
[226] Catherine Communal,et al. Opposing Effects of β1- and β2-Adrenergic Receptors on Cardiac Myocyte Apoptosis Role of a Pertussis Toxin–Sensitive G Protein , 1999 .
[227] GerdHasenfuss,et al. Downregulation of the Na+-Creatine Cotransporter in Failing Human Myocardium and in Experimental Heart Failure , 1999 .
[228] S. Neubauer,et al. Downregulation of the Na(+)-creatine cotransporter in failing human myocardium and in experimental heart failure. , 1999, Circulation.
[229] M. Crompton,et al. The mitochondrial permeability transition pore. , 1999, Biochemical Society symposium.
[230] A. Takeshita,et al. Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium. , 1999, Circulation research.
[231] B. Stoel,et al. Diastolic dysfunction in hypertensive heart disease is associated with altered myocardial metabolism. , 1999, Circulation.
[232] R. Winslow,et al. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. , 1999, Circulation research.
[233] D. Sawyer,et al. Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein. , 1999, Circulation.
[234] D. Kass,et al. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies. , 1999, Circulation research.
[235] Lionel H. Opie,et al. Heart Physiology: From Cell to Circulation , 2003 .
[236] O. Lutz,et al. 31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy. , 1998, Circulation.
[237] B. Rajagopalan,et al. Mitral regurgitation: impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humans. , 1998, Circulation.
[238] S. Neubauer,et al. Cardiac high-energy phosphate metabolism in patients with aortic valve disease assessed by 31P-magnetic resonance spectroscopy. , 1997, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.
[239] D. Kelly,et al. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. , 1996, Circulation.
[240] S. Neubauer,et al. Contributions of 31P-magnetic resonance spectroscopy to the understanding of dilated heart muscle disease. , 1995, European heart journal.
[241] T. Inubushi,et al. Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by 31P magnetic resonance spectroscopy. , 1995, Circulation.
[242] 矢部 隆宏. Detection of myocardial ischemia by [31]P magnetic resonance spectroscopy during handgrip exercise , 1995 .
[243] S. Morikawa,et al. Detection of myocardial ischemia by 31P magnetic resonance spectroscopy during handgrip exercise. , 1994, Circulation.
[244] J. Cohn,et al. Plasma Norepinephrine, Plasma Renin Activity, and Congestive Heart Failure Relations to Survival and the Effects of Therapy in V‐HeFT II , 1993, Circulation.
[245] K. Takeda,et al. 31P MR spectroscopy in hypertrophic cardiomyopathy: comparison with Tl-201 myocardial perfusion imaging. , 1993, American heart journal.
[246] S. Neubauer,et al. 31P Magnetic Resonance Spectroscopy in Dilated Cardiomyopathy and Coronary Artery Disease: Altered Cardiac High‐Energy Phosphate Metabolism in Heart Failure , 1992, Circulation.
[247] M. Lesch,et al. Mitochondrial abnormalities in myocardium of dogs with chronic heart failure. , 1992, Journal of molecular and cellular cardiology.
[248] E. E. van der Wall,et al. Cardiac metabolism in patients with dilated and hypertrophic cardio‐myopathy: Assessment with proton‐decoupled P‐31 MR spectroscopy , 1992, Journal of Magnetic Resonance Imaging.
[249] J. Schaper,et al. Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man. , 1992, Journal of molecular and cellular cardiology.
[250] E. Fleck,et al. Myocardial adenine nucleotide concentrations and myocardial norepinephrine content in patients with heart failure secondary to idiopathic dilated or ischemic cardiomyopathy. , 1992, The American journal of cardiology.
[251] M W Weiner,et al. Metabolic response of the human heart to inotropic stimulation: In vivo phosphorus‐31 studies of normal and cardiomyopathic myocardium , 1992, Magnetic resonance in medicine.
[252] G. Radda,et al. Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy , 1991, The Lancet.
[253] C. Hardy,et al. Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy. , 1991, American heart journal.
[254] M. Weiner,et al. In vivo phosphorus-31 spectroscopic imaging in patients with global myocardial disease. , 1990, The American journal of cardiology.
[255] J. Schaper,et al. Ultrastructural Morphometric Analysis of Myocardium from Dogs, Rats, Hamsters, Mice, and from Human Hearts , 1985, Circulation research.
[256] L. Opie,et al. Adrenaline-induced "oxygen-wastage" and enzyme release from working rat heart. Effects of calcium antagonism, beta-blockade, nicotinic acid and coronary artery ligation. , 1979, Journal of molecular and cellular cardiology.
[257] L Margulis,et al. Symbiotic theory of the origin of eukaryotic organelles; criteria for proof. , 1975, Symposia of the Society for Experimental Biology.
[258] E. J. Battersby,et al. Effect of pressure development on oxygen consumption by isolated rat heart. , 1967, The American journal of physiology.
[259] P. Mitchell. Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism , 1961, Nature.
[260] A. Patz. Experimental studies. , 1955, American journal of ophthalmology.
[261] F. Rosenfeldt,et al. The Effect of Coenzyme Q 10 on Morbidity and Mortality in Chronic Heart Failure Results From Q-SYMBIO : A Randomized Double-Blind Trial , 2022 .