Neuropsychiatric Considerations in the Treatment of Hypertension

Algorithms have been developed to guide the treatment of simple hypertension. The basic algorithms are modified in the face of concurrent medical conditions, taking into account the various pharmacological effects of antihypertensive agents. This article reviews the neuropsychiatric effects of the major classes of antihypertensive agents (ganglionic blockers, centrally acting agents, diuretics, vasodilators, beta-blockers, calcium channel blockers and angiotensin converting enzyme inhibitors). The purported efficacy of some antihypertensive agents in the treatment of psychiatric conditions is also discussed. Beneficial as well as adverse neuropsychiatric effects are reviewed. In this way, guidelines for the treatment of hypertension are suggested which take into account a broad spectrum of neuropsychiatric considerations.

[1]  R. Zusman.  Alternatives to step-care therapy for hypertension , 1991 .

[2]  A. LaCroix,et al.  Thiazide Diuretic Agents and the Incidence of Hip Fracture , 1990 .

[3]  M. Jenike.  Approaches to the patient with treatment-refractory obsessive compulsive disorder. , 1990, The Journal of clinical psychiatry.

[4]  Amsterdam,et al.  Problems associated with the diagnosis of depression. Discussion , 1990 .

[5]  C. Berne,et al.  A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension. , 1989, The New England journal of medicine.

[6]  Nelson Jc,et al.  Stimulants in the treatment of depression: a critical overview. , 1989 .

[7]  J. Dimsdale,et al.  Neuropsychological side effects of beta-blockers. , 1989, Archives of internal medicine.

[8]  W. de Oliveira Júnior.  [The effects of antihypertensive therapy on the quality of life]. , 1989, Arquivos brasileiros de cardiologia.

[9]  J. Nelson,et al.  Stimulants in the treatment of depression: a critical overview. , 1989, The Journal of clinical psychiatry.

[10]  M. Lader.  Beta-adrenoceptor antagonists in neuropsychiatry: an update. , 1988, The Journal of clinical psychiatry.

[11]  F. Gengo,et al.  The Effect of ß-Blockers on Mental Performance on Older Hypertensive Patients , 1988 .

[12]  T. Uhde,et al.  Controlled study of verapamil for treatment of panic disorder. , 1988, The American journal of psychiatry.

[13]  J. Fogelman.  Verapamil caused depression, confusion, and impotence. , 1988, The American journal of psychiatry.

[14]  H. Gavras,et al.  Angiotensin Converting Enzyme Inhibitors Properties and Side Effects , 1988, Hypertension.

[15]  R. Russell,et al.  Side Effects of Calcium Channel Blockers , 1988, Hypertension.

[16]  S. Hyman,et al.  Calcium channel blockers in psychiatry. , 1987, Psychosomatics.

[17]  M. Fauman.  The relation of dominant and submissive behavior to the humoral immune response in BALB/c Mice , 1987, Biological Psychiatry.

[18]  J. Rosenbaum,et al.  Verapamil in the treatment of recurrent unipolar depression , 1987, Biological Psychiatry.

[19]  O. Wolkowitz,et al.  Clinical and biochemical effects of verapamil administration to schizophrenic patients. , 1987, Archives of general psychiatry.

[20]  Giannini Mc,et al.  Comparison of clonidine and lithium in the treatment of mania. , 1986 .

[21]  J. Cutler,et al.  The effects of drug treatment for hypertension on morbidity and mortality from cardiovascular disease: a review of randomized controlled trials. , 1986, Progress in cardiovascular diseases.

[22]  A. Giannini,et al.  Verapamil in acute psychosis. , 1986, Psychosomatics.

[23]  S. Bronheim,et al.  Calcium antagonists in the treatment of Tourette's disorder. , 1986, The American journal of psychiatry.

[24]  Y. Lecrubier,et al.  Efficacy of clonidine in 24 patients with acute mania. , 1986, The American journal of psychiatry.

[25]  P. Keck,et al.  Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital. , 1986, The American journal of psychiatry.

[26]  James R. Murphy,et al.  Calcium antagonists in mania: A double-blind study of verapamil , 1986, Psychiatry Research.

[27]  G. Klerman,et al.  The effects of antihypertensive therapy on the quality of life. , 1986, The New England journal of medicine.

[28]  R. M. Greendyke,et al.  Propranolol Treatment of Assaultive Patients with Organic Brain Disease: A Double-Blind Crossover, Placebo-Controlled Study , 1986, The Journal of nervous and mental disease.

[29]  A. Shepherd,et al.  Differential Hemodynamic and Sympathoadrenal Effects of Sodium Nitroprusside and Hydralazine in Hypertensive Subjects , 1986, Journal of cardiovascular pharmacology.

[30]  R. Byington,et al.  Effect of propranolol after acute myocardial infarction in patients with congestive heart failure. , 1986, Circulation.

[31]  M. Anscher,et al.  Randomized clinical trial of atenolol in patients with alcohol withdrawal. , 1985, The New England journal of medicine.

[32]  M. Weinberger.  Antihypertensive therapy and lipids. Evidence, mechanisms, and implications. , 1985, Archives of internal medicine.

[33]  T. Mcmahon.  Bipolar affective symptoms associated with use of captopril and abrupt withdrawal of pargyline and propranolol. , 1985, The American journal of psychiatry.

[34]  W. Kannel,et al.  Unrecognized myocardial infarction and hypertension: the Framingham Study. , 1985, American heart journal.

[35]  Giannini Mc,et al.  Antimanic Effects of Verapamil , 1984 .

[36]  H. Black,et al.  Essential hypertension: psychiatric aspects and use of psychotropics. , 1984, Psychosomatics.

[37]  L. Cohen.  More data on hyperprolactinemia. , 1984, The American journal of psychiatry.

[38]  J. Melby,et al.  Enalapril and hypertension. , 1984, The American journal of psychiatry.

[39]  J. Johnson.  Psychiatric Uses of Antiadrenergic and Adrenergic Blocking Drugs , 1984, The Journal of nervous and mental disease.

[40]  H. E. King,et al.  Effect of antihypertensive treatment on the behavioral consequences of elevated blood pressure. , 1984, Hypertension.

[41]  N. Kaplan.  Therapy of mild hypertension: an overview. , 1984, The American journal of cardiology.

[42]  Zubenko Gs,et al.  Mood-elevating effect of captopril in depressed patients , 1984 .

[43]  R. Nixon,et al.  Mood-elevating effect of captopril in depressed patients. , 1984, The American journal of psychiatry.

[44]  G. Oxenkrug,et al.  Use of propranolol for provoked and unprovoked episodes of rage. , 1983, The American journal of psychiatry.

[45]  Rick S. Blum,et al.  Impairment of memory function by antihypertensive medication. , 1983, Archives of general psychiatry.

[46]  P. Barreira,et al.  PROPRANOLOL IN THE TREATMENT OF NEUROLEPTIC-INDUCED AKATHISIA , 1983, The Lancet.

[47]  J. Rabkin,et al.  Hypertension and DSM-III depression in psychiatric outpatients. , 1983, The American journal of psychiatry.

[48]  D. Benson,et al.  Neuropsychiatric manifestations of antihypertensive medications. , 1983, Psychiatric medicine.

[49]  M. Weissman,et al.  Use of a structured diagnostic interview to identify bipolar disorder in adolescent inpatients: frequency and manifestations of the disorder. , 1983, The American journal of psychiatry.

[50]  M. Kuhar.  Receptors for clonidine in brain: insights into therapeutic actions. , 1982, The Journal of clinical psychiatry.

[51]  D. Harrison,et al.  Acute and Chronic Pharmacodynamic Interaction of Verapamil and Digoxin in Atrial Fibrillation , 1982, Circulation.

[52]  David John Adams,et al.  The effect of propranolol on uncontrolled rage outbursts in children and adolescents with organic brain dysfunction. , 1982, Journal of the American Academy of Child Psychiatry.

[53]  E. Paykel,et al.  Psychiatric Side Effects of Antihypertensive Drugs Other Than Reserpine , 1982, Journal of clinical psychopharmacology.

[54]  S. Cooper,et al.  Propranolol in Schizophrenia , 1981, British Journal of Psychiatry.

[55]  H. Black,et al.  Psychiatric Complications of Antihypertensive Medications , 1981, The Journal of nervous and mental disease.

[56]  D. Janowsky,et al.  Interfaces of psychopharmacology and cardiology--part one. , 1981, Journal of Clinical Psychiatry.

[57]  Flaherty Ja.  Psychiatric complications of medical drugs. , 1979 .

[58]  D. Redmond,et al.  CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS , 1978, The Lancet.

[59]  Sandifer Mg.  The hypertensive psychiatric patient: pharmacologic problems. , 1978 .

[60]  W. Bant.  Antihypertensive drugs and depression: a reappraisal , 1978, Psychological Medicine.

[61]  G. Stokes,et al.  Prazosin: the first-dose phenomenon. , 1976, British medical journal.

[62]  C. Dollery,et al.  The clinical pharmacology of beta-adrenoceptor-blocking drugs. , 1976, Progress in cardiovascular diseases.

[63]  Librach Im.  Letter: Medical manpower. , 1976 .

[64]  W. Lewis.  Iatrogenic psychotic depressive reaction in hypertensive patients. , 1971, The American journal of psychiatry.

[65]  W. Leaman,et al.  Treatment of essential hypertension. , 1970, Pennsylvania medicine.

[66]  W. M. Smith,et al.  Comparative evaluation of Rauwolfia whole root and reserpine , 1969, Clinical pharmacology and therapeutics.

[67]  Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. , 1967, JAMA.

[68]  E. Paykel.  Hallucinosis on Combined Methyldopa and Pargyline , 1966, British medical journal.

[69]  W. Lovenberg,et al.  Monoamine Oxidase Inhibitors, Tyramine, and Cheese , 1964 .

[70]  F. R. Zadik.  FRACTURE OF THE FEMORAL NECK. , 1964, Lancet.

[71]  Ayd Fj.  Drug-induced depression; fact of fallacy. , 1958 .

[72]  A. Davignon,et al.  Depressive states during Rauwolfia therapy for arterial hypertension; a report of 30 cases. , 1956, Canadian Medical Association journal.

[73]  I. Kass,et al.  Treatment of hypertensive patients with Rauwolfia compounds and reserpine; depressive and psychotic changes. , 1955 .

[74]  E. Freis.  Mental depression in hypertensive patients treated for long periods with large doses of reserpine. , 1954, The New England journal of medicine.

[75]  H. Perry,et al.  Syndrome simulating collagen disease caused by hydralazine (Apresoline). , 1954, Journal of the American Medical Association.