Proteomic analysis identifies HMGA2 as a novel biomarker of overall survival in papillary renal cell carcinoma

Although papillary renal cell carcinoma (PRCC) has a relatively favorable prognosis, a small number of patients with lymph node or distant metastasis have a poor prognosis. Owing to the complex typing and heterogeneity of PRCC, it remains difficult to provide risk stratification. The objective of our research was to identify potential markers of PRCC prognosis.

[1]  Junshik Hong,et al.  Transcriptional signatures of the BCL2 family for individualized acute myeloid leukaemia treatment , 2022, Genome Medicine.

[2]  Jared C Malke,et al.  Obesity is associated with altered tumor metabolism in metastatic melanoma. , 2022, Clinical cancer research : an official journal of the American Association for Cancer Research.

[3]  Hanmei Xu,et al.  Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma , 2022, Molecular Cancer.

[4]  W. P. Galej,et al.  Structural studies of the spliceosome: Bridging the gaps , 2022, Current opinion in structural biology.

[5]  Xin Ma,et al.  Histological features suggestive of survival in patients with renal cell carcinoma and tumor thrombus: A single-center experience , 2022, Frontiers in Oncology.

[6]  W. Linehan,et al.  Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma , 2022, Journal of Experimental & Clinical Cancer Research.

[7]  W. Linehan,et al.  Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma , 2022, Journal of Experimental & Clinical Cancer Research.

[8]  M. Rubin,et al.  WHO 2022 landscape of papillary and chromophobe renal cell carcinoma , 2022, Histopathology.

[9]  R. Vago,et al.  Long Non-Coding RNAs as Novel Biomarkers in the Clinical Management of Papillary Renal Cell Carcinoma Patients: A Promise or a Pledge? , 2022, Cells.

[10]  Jing Wang,et al.  LncRNA SNHG1 promotes renal cell carcinoma progression through regulation of HMGA2 via sponging miR‐103a , 2022, Journal of clinical laboratory analysis.

[11]  G. Shi,et al.  A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population , 2022, Nature Communications.

[12]  Shijie Li,et al.  Association between preoperative serum Cystatin‐C levels and postsurgical oncological prognosis in patients with PRCC: A retrospective cohort study , 2022, Cancer medicine.

[13]  F. Fernandez-Lima,et al.  AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes , 2022, Nucleic acids research.

[14]  Ran Wang,et al.  Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney , 2022, The Journal of pathology.

[15]  M. Gross,et al.  Mass Spectrometry-Based Structural Proteomics for Metal Ion/Protein Binding Studies , 2022, Biomolecules.

[16]  Jian Wang,et al.  HMGA2 facilitates colorectal cancer progression via STAT3-mediated tumor-associated macrophage recruitment , 2022, Theranostics.

[17]  P. Russo,et al.  Papillary Renal Cell Carcinoma: A Single Institutional Study of 199 Cases Addressing Classification, Clinicopathologic and Molecular Features, and Treatment Outcome , 2021, Modern Pathology.

[18]  Jiaqiao Zhang,et al.  Clinicopathological Features and Prognostic Outcomes of Papillary Renal Cell Carcinoma , 2021, International journal of general medicine.

[19]  Wei Hu,et al.  A novel prognostic cancer-related lncRNA signature in papillary renal cell carcinoma , 2021, Cancer cell international.

[20]  Guoxi Zhang,et al.  A Review of Recent Research on the Role of MicroRNAs in Renal Cancer , 2021, Medical science monitor : international medical journal of experimental and clinical research.

[21]  H. Ditzel,et al.  HMGA2 as a Critical Regulator in Cancer Development , 2021, Genes.

[22]  A. Iwama,et al.  Overexpression of Hmga2 activates Igf2bp2 and remodels transcriptional program of Tet2-deficient stem cells in myeloid transformation , 2021, Oncogene.

[23]  Min Liu,et al.  Overexpression of enolase 2 is associated with worsened prognosis and increased glycikolysis in papillary renal cell carcinoma , 2020, Journal of cellular physiology.

[24]  M. Gleave,et al.  LIN28B promotes the development of neuroendocrine prostate cancer. , 2020, The Journal of clinical investigation.

[25]  Junming Xu,et al.  Integrative Proteomic Characterization of Human Lung Adenocarcinoma , 2020, Cell.

[26]  Yue Wu,et al.  The regulation of acetylation and stability of HMGA2 via the HBXIP-activated Akt–PCAF pathway in promotion of esophageal squamous cell carcinoma growth , 2020, Nucleic acids research.

[27]  K. Preissner,et al.  Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation , 2020, Nature Communications.

[28]  Z. Dong,et al.  MiR-497 inhibits cell proliferation and invasion ability by targeting HMGA2 in pancreatic ductal adenocarcinoma. , 2020, European review for medical and pharmacological sciences.

[29]  C. Porta,et al.  Drug resistance in papillary RCC: from putative mechanisms to clinical practicalities , 2019, Nature Reviews Urology.

[30]  Shizhen Zhang,et al.  Oncological role of HMGA2 (Review). , 2019, International journal of oncology.

[31]  M. Attimonelli,et al.  Papillary Renal Cell Carcinomas Rewire Glutathione Metabolism and Are Deficient in Both Anabolic Glucose Synthesis and Oxidative Phosphorylation , 2019, Cancers.

[32]  M. Bilen,et al.  A Review of Papillary Renal Cell Carcinoma and MET Inhibitors , 2019, Kidney cancer.

[33]  T. Choueiri,et al.  Cabozantinib in advanced non-clear-cell renal cell carcinoma: a multicentre, retrospective, cohort study. , 2019, The Lancet. Oncology.

[34]  T. A. Al Hussain,et al.  Papillary Renal Cell Carcinoma (PRCC): An Update. , 2019, Advances in anatomic pathology.

[35]  X. Hua,et al.  The genomic and epigenomic evolutionary history of papillary renal cell carcinomas , 2018, Nature Communications.

[36]  Mingwei Liu,et al.  A proteomic landscape of diffuse-type gastric cancer , 2018, Nature Communications.

[37]  Da Li,et al.  miR-302a-5p/367-3p-HMGA2 axis regulates malignant processes during endometrial cancer development , 2018, Journal of Experimental & Clinical Cancer Research.

[38]  H. Moch,et al.  WHO-ISUP-Graduierungssystem für Nierenkarzinome , 2016, Der Pathologe.

[39]  Yuhong Wang,et al.  Transcriptional activation of FN1 and IL11 by HMGA2 promotes the malignant behavior of colorectal cancer. , 2016, Carcinogenesis.

[40]  Steven J. M. Jones,et al.  Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. , 2016, The New England journal of medicine.

[41]  J. Pous,et al.  Crystal Structure of a Complex of DNA with One AT-Hook of HMGA1 , 2012, PloS one.

[42]  T. Glasz,et al.  [Papillary renal cell carcinoma]. , 2001, Orvosi hetilap.

[43]  Z. Cao,et al.  Mass Spectrometry-Based Proteomics for Biomarker Discovery. , 2022, Methods in molecular biology.

[44]  H. Moch.  [The WHO/ISUP grading system for renal carcinoma]. , 2016, Der Pathologe.