CASE REPORT Treatment of refractory hand warts by isolated limb infusion with melphalan and actinomycin D

We present an immunocompetent man with extensive warts on the hands, refractory to a number of conventional treatment modalities and causing substantial morbidity and impairment of normal function. Isolated limb infusion (regional intra‐arterial chemotherapy) with melphalan and actinomycin D was performed, with substantial clearing of the warts within 2 months. Treatment‐induced morbidity was limited to mild local erythema and oedema which resolved within 3 weeks. After 9 months’ follow up, the patient had only a few residual warts and was able to resume normal activities.

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