Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Tom R. Gaunt | Nicholette D. Palmer | Y. J. Kim | Benjamin J. Wright | Audrey Y. Chu | S. R. Kulkarni | Yong Li | M. Jarvelin | J. Danesh | R. Collins | J. Murabito | S. Bandinelli | C. Gieger | F. Kronenberg | M. Waldenberger | D. Absher | T. Assimes | L. Wain | N. Shrine | P. Deloukas | M. Tobin | S. Gabriel | G. Abecasis | T. Lumley | T. Lehtimäki | U. Thorsteinsdóttir | A. Kong | K. Stefánsson | H. Hakonarson | D. Altshuler | E. Boerwinkle | E. Halperin | V. Salomaa | M. Perola | A. Adeyemo | J. Hirschhorn | M. Laakso | J. O’Connell | W. Goessling | S. Bergmann | M. Boehnke | C. Loley | I. König | Y. Okada | P. Ridker | D. Chasman | N. Samani | W. McArdle | A. Balmforth | P. Braund | M. Mangino | J. Thompson | P. Munroe | M. Caulfield | M. Farrall | T. Frayling | Y. Teo | V. Gudnason | V. Emilsson | R. Wilensky | J. Viikari | D. Shriner | R. Vasan | J. Haerting | I. Borecki | A. Chakravarti | S. Eyheramendy | M. Imboden | A. Hingorani | A. Zonderman | M. Evans | D. Couper | J. Whitfield | Stefan Enroth | G. Zhai | E. Lakatta | A. Dehghan | Shih-Jen Hwang | W. Kao | F. Rivadeneira | Daniel Levy | J. Witteman | C. Fox | G. Thorleifsson | J. Beilby | L. Palmer | M. Reilly | G. Malerba | G. Thorgeirsson | S. Kardia | J. Erdmann | C. Hengstenberg | T. Meitinger | W. Lieb | F. Cambien | A. Corsi | M. Uda | K. Lohman | D. Siscovick | P. Talmud | D. Arking | D. Grobbee | J. Peden | P. Whincup | A. Metspalu | T. Esko | A. Doumatey | G. Montgomery | H. Snieder | D. Ruderfer | E. Ingelsson | P. Linsel-Nitschke | C. Perret | Michael H. Preuss | C. Meisinger | K. Stark | L. Tiret | L. Scott | K. Mohlke | L. Bonnycastle | H. Stringham | A. Swift | B. Voight | S. Kathiresan | O. Melander | C. Guiducci | P. Froguel | S. Coassin | N. Klopp | B. Paulweber | T. Illig | D. Hadley | J. Staessen | M. Blettner | I. Heid | B. Hedblad | M. Lathrop | D. Zélénika | I. Rudan | H. Ongen | J. Gottdiener | W. Rosamond | C. Langefeld | J. Karjalainen | A. Isaacs | C. Willenborg | H. Grallert | T. Pers | L. Franke | I. Prokopenko | H. Hólm | Jong-Young Lee | B. Han | L. Cupples | F. Ricceri | N. Soranzo | Xiuqing Guo | I. Kullo | M. Bots | H. Schmidt | G. Matullo | R. Biffar | G. Homuth | A. Teumer | G. Curhan | R. McPherson | D. Saleheen | J. Bis | M. Larson | J. Kooner | O. Gottesman | E. Bottinger | I. Barroso | S. Shaw-Hawkins | T. Johnson | E. Albrecht | N. Amin | C. Hayward | I. Kolčić | O. Polašek | V. Vitart | M. de Andrade | G. Eiriksdottir | J. Faul | M. Garcia | E. Holliday | L. Launer | P. Vollenweider | T. Aspelund | S. Heckbert | D. Arnett | V. Chouraki | T. Mosley | S. Seshadri | M. Feitosa | X. Sim | J. Divers | J. Luan | I. Nolte | A. Robino | A. Stančáková | F. Takeuchi | B. Tayo | Jinghua Zhao | T. Katsuya | J. Kuusisto | Y. Milaneschi | L. Raffel | J. Chambers | B. Freedman | N. Kato | P. van der Harst | L. Wagenknecht | E. Fox | W. Palmas | A. Morrison | N. Bouatia-Naji | A. Scuteri | P. Meneton | A. Shuldiner | R. Laaksonen | G. Verwoert | N. Glazer | E. Sijbrands | S. Ganesh | N. Steinle | A. Parsa | A. Weder | M. Go | L. Yengo | M. Cornelis | R. Lawrence | Carl G. P. Platou | K. Khaw | K. Hveem | J. Bragg-Gresham | A. Demirkan | Å. Johansson | M. Kleber | L. Lyytikäinen | K. Volcik | A. Wong | M. Burnett | M. Kumari | H. Scharnagl | M. Bochud | M. Kivimaki | D. Kuh | P. Pramstaller | T. Quertermous | Guo Li | W. Renner | E. Rochtchina | M. Denniff | I. Tzoulaki | D. Ellinghaus | T. Haritunians | A. Takahashi | K. Kent | A. Pichard | V. Nicaud | J. Jukema | R. Katz | C. Fuchsberger | A. Parker | Shufeng Chen | J. Hixson | A. Doering | J. Gaspoz | I. Guessous | T. Jafar | K. Musunuru | N. Friedrich | M. Nauck | M. Dörr | R. Rettig | H. Kroemer | Ming-Huei Chen | P. Hamet | F. Ernst | E. Salvi | W. Igl | J. Laitinen | P. Zitting | D. Cusi | D. Waterworth | P. Muntner | I. M. Leach | S. Trompet | T. Grammer | Yingchang Lu | J. Sehmi | N. Verweij | M. Cocca | A. Rasheed | B. Ludwig | N. Lee | Pankaj Sharma | S. Guarrera | M. McEvoy | T. Zeller | A. Schillert | C. Proust | C. Sinning | K. Lackner | P. Diemert | Y. Tabara | H. Ueshima | Y. Kita | T. Miki | Y. T. van der Schouw | N. Onland-Moret | G. Lucas | E. Org | C. Uiterwaal | M. Laan | B. Stengel | N. Kamatani | Peng Chen | G. Chandak | Mark Seielstad | B. Winkelmann | M. Metzger | J. Hopewell | R. Rodeheffer | J. Liu | Christian Müller | O. Devuyst | C. Peralta | M. Pruijm | Jiang He | B. Stricker | F. Murgia | C. Pattaro | T. Okamura | D. Czamara | D. Toniolo | T. Stojaković | K. Marciante | J. Willerson | K. Greiser | M. Viigimaa | R. Zweiker | M. Redfield | M. Sale | Chien-Hsiun Chen | M. Isono | Jer-Yuarn Wu | T. Zemunik | G. Pistis | D. Taliun | A. Tin | S. Sedaghat | J. Felix | B. Ponte | M. Rheinberger | K. Suszták | S. Maeda | Neil Risch | Katja Butterbach | H. Mei | A. Dreisbach | M. Boban | Andrew A. Hicks | S. Stracke | M. Pirastu | M. Adam | J. Palmen | Anke Tonjes | A. K. Dieffenbach | C. Sala | M. Ikram | M. Rudock | L. Qu | Man Li | T. Wong | Lyudmyla Kedenko | Sonny Dandona | J. Stritzke | W. V. van Gilst | A. Tomaschitz | M. Haun | B. Kollerits | M. Ciullo | L. Portas | D. Ruggiero | Aude Saint-Pierre | R. Sorice | P. D'Adamo | K. Wiggins | J. Meschia | L. Loehr | M. Barbalić | A. Meinitzer | Keith L. Keene | P. Bruse | J. Aragam | M. Cavalieri | S. Kloiber | J. Stafford | Yoon Shin Cho | T. Salako | Vladan Mijatovic | Maija Garnaas | D. Ackermann | G. Thun | G. Jacobs | M. Struchalin | Stephen J Hancock | T. Nikopensius | Z. Aherrahrou | A. Wagner | Anja Medack | C. Knouff | C. Bickel | S. Kinra | C. Yajnik | S. Sõber | D. Vinay | Santosh Dahgam | M. Tomaszewski | S. Brand | G. Veldre | C. S. Janipalli | K. R. Mani | E. Zukowska-szczechowska | H. Wichmann | O. Jarinova | I. Chen | Lowell Satler | W. Matthai | H. Dobnig | Annette Peters | Philip J Howard | N. Watzinger | N. Smith | Peter J. van der Most | Megan E. Rudock | E. Tai | Rita P. S. Middelberg | Ying A Wang | Samer Najjar | H. Brenner | J. Attia | J. Chalmers | Dag S. Thelle | Frank Hu | J. Yao | U. Gyllensten | Serkalem Demissie-Banjaw | Steve E. Humphries | M. Sjögren | O. Raitakari | Johanne Tremblay | G. D. Smith | Stephen E. Epstein | Harry Campbell | N. Probst-Hensch | Yali Li | Li Chang | Kenneth M. Rice | Linda S. Adair | K. Endlich | Wei-Min Chen | L. Lind | R. Clarke | Winfried März | Richard S. Cooper | Elizabeth J. Atkinson | Yuanfang Chen | Hua Tang | Josh C. Denny | Robert Roberts | Toshihiro Tanaka | R. Schmidt | J. P. Casas | Xiaofeng Zhu | P. Gasparini | U. Völker | S. Gretarsdottir | Holly B. Kramer | I. Ford | F. Tsai | Khanh-dung Nguyen | M. Olden | T. Spector | Goncalo R. Linda S. Myriam David Najaf Dan E. Pankaj Yurii Abecasis Adair Alexander Altshuler Amin A | Y. Aulchenko | H. Kim | Yukinori Jer-Yuarn Dongfeng Fumihiko Atsushi Shiro Tatsuhik Okada Wu Gu Takeuchi Takahashi Maeda Tsu | S. Fann | Muredach P Heribert Themistocles L. Alistair Christian Inke Reilly Schunkert Assimes Hall Hengstenbe | Andreas Ziegler | Laura R. Wayne D. Emelia Talin David Joanne Ying A. Brun Loehr Rosamond Benjamin Haritunians Couper | Stephan B. Norbert Jayashri Robert Lars Richard J. Karin H Felix Watzinger Aragam Zweiker Lind Rodeh | Carsten A. Böger | T. Tsunoda | Pilar Galan | James F. Wilson | S. Bornstein | K. Werdan | M. Orrù | A. Franke | Peter Kovacs | R. Carroll | Rodney J. Scott | Terrence Forrester | Bernhard K. Krämer | A. Smith | A. Grosshennig | M. Artigas | M. Stumvoll | Toshiko Tanaka | L. Rose | H. Watkins | Weihua Zhang | J. Scott | M. Kähönen | Toshihiro Tanaka | J. Coresh | Mathias Gorski | A. Uitterlinden | Sheila Ulivi | Feng Zhang | C. McKenzie | Narisu Narisu | Vasyl Pihur | T. Harris | Reedik Mägi | Anna-Liisa Hartikainen | Dongfeng Gu | A. Goel | M. Kubo | Toshiko Tanaka | B. Oostra | C. V. van Duijn | B. Psaty | S. Kardia | M. Morken | Paul Mitchell | F. Collins | Christopher J. O'Donnell | Mingyao Li | Stephan B. Felix | C. Nelson | R. F. Loos | Vincent Mooser | A. Köttgen | S. Pilz | Paolo Vineis | Anders Hamsten | Xiaoling Wang | Michael A. Nalls | F. G. R. Fowkes | Fadi J. Charchar | Peter E. H. Schwarz | Andrew D. Johnson | Mingyao Li | Heribert Schunkert | Karl Andersen | Joseph M Devaney | Marcus Fischer | George A. Wells | Charles N. Rotimi | Roberto Elosua | H. Völzke | Fredrik Nyberg | Richard W. Morris | Jerome I. Rotter | Alan F. Wright | Albert Hofman | Johannes H. Smit | B.W.J.H. Penninx | Stephen Fortmann | Carlos Iribarren | Richard Myers | Steven Sidney | Yan V. Sun | Paul R. Burton | Debbie A. Lawlor | Stephan J. L. Bakker | Mark Woodward | Wolfgang Koenig | Olli T. Raitakari | Jacques S. Beckmann | C. Shaffer | Erkki Vartiainen | Oscar H. Franco | Yusuke Nakamura | A. Jackson | Stephen G. Ball | Morris J. Brown | S. Blankenberg | Honghuang Lin | Qiong Yang | Meredith C. Foster | Sarah H. Wild | Catherine Helmer | Alistair S. Hall | S. Schreiber | H. Wallaschofski | Ville Aalto | Yi-An Ko | Antonio Lupo | Belen Ponte | George B. Ehret | Ivana Persico | Jean-Charles Lambert | Jyotika K. Fernandes | Nick Hastie | Myriam Alexander | Pankaj Arora | Eva Brand | Yen-Pei C. Chang | Nish Chaturvedi | Matthew N. Cooper | Ian N. M. Day | Yanbin Dong | Cristiano Fava | Jürgen Grässler | Gina Hilton | Steven C. Hunt | Naoharu Iwai | Tatiana Kuznetsova | Francesco U. S. Mattace-Raso | Peter Nilsson | Toshio Ogihara | RickTwee-Hee Ong | Paul F. O’Reilly | Andrew S. Plump | Annika Rosengren | Steven M. Schwartz | Gang Shi | Andrew B. Singleton | Andrew Taylor | Vikal Tripathy | Satoshi Umemura | Xiaoling Wang | Thomas J. Wang | Ying Wu | J. H. Young | Haidong Zhu | Su-Chi Lim | Terri L. Young | Daehee Kang | Li Chen | Alexandre F. R. Stewart | Hans-Jürgen Rupprecht | Thomas F. Münzel | Janja Nahrstedt | Bernhard O. Böhm | Michael M. Hoffmann | Karl Winkler | William Matthai | Joseph M. Lindsay | Max C. Walker | Patricia P. Chang | Jaap W. Deckers | Gary F. Mitchell | Stephen J. Hancock | Sylvia E. Rosas | Yongmei Liu | Ian H. de Boer | Madhumathi Rao | Muhammad Islam | K. Taylor | N. Wareham | G. Navis | M. Hlatky | Jeffrey R. Gulcher | Daniel J. Rader | Dena G. Hernandez | V. Mooser | J. Tuomilehto | Braxton D. Mitchell | P. Elliott | Tin Aung | J. Terzić | A. Dominiczak | R. Waksman | Daniel Taliun | Thorsten Reffelmann | J. Connell | Man Li | A. Folsom | S. Hercberg | R. Bergman | S. Heath | L. Peltonen | N. Burtt | Emelia J. Benjamin | B. Buckley | G. Gambaro | J. Wang | Jingzhong Ding | M. V. K. Kumar | W. T. Longstreth | M. Marmot | D. Prabhakaran | A. Rosengren | L. Chen | R. Schnabel | Stephen T. Turner | Joshua W. Knowles | C. Newton‐Cheh | Alan S. Go | Jennifer A. Smith | David P. Strachan | L. Groop | D. Rao | Nicholas G. Martin | Jackie A. Cooper | L. Ferrucci | Philipp S Wild | Yong Li | R. Hardy | J. A. H. Bolton | Yali Li | T. Ohkubo | Kazuhiko Yamamoto | Toshiko Tanaka | C. Iribarren | Antonio Lupo | K. Taylor | Sarah H Wild | W. Longstreth | Toshiko Tanaka | B. Penninx | Yong Li | S. Felix | Paolo Gasparini | Fadi J Charchar | Gary F Mitchell | Roberto Elosúa | S. Umemura | Haidong Zhu | R. Mägi | Carole Proust | F. J. Charchar | E. Atkinson

[1]  J. Hirschhorn,et al.  Biological interpretation of genome-wide association studies using predicted gene functions , 2015, Nature Communications.

[2]  Peggy Hall,et al.  The NHGRI GWAS Catalog, a curated resource of SNP-trait associations , 2013, Nucleic Acids Res..

[3]  Matteo Trudu,et al.  Common noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expression , 2013, Nature Medicine.

[4]  John P A Ioannidis,et al.  The power of meta-analysis in genome-wide association studies. , 2013, Annual review of genomics and human genetics.

[5]  U. Simeoni,et al.  Developmental Origins of Chronic Renal Disease: An Integrative Hypothesis , 2013, International journal of nephrology.

[6]  Kai-Uwe Eckardt,et al.  Evolving importance of kidney disease: from subspecialty to global health burden , 2013, The Lancet.

[7]  Y. Teo,et al.  Comparing methods for performing trans-ethnic meta-analysis of genome-wide association studies. , 2013, Human molecular genetics.

[8]  B. Stranger,et al.  Chromatin marks identify critical cell types for fine mapping complex trait variants , 2012, Nature Genetics.

[9]  Sylvia Stracke,et al.  Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. , 2012, Human molecular genetics.

[10]  M. Woodward,et al.  Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis , 2012, The Lancet.

[11]  M. Woodward,et al.  Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without hypertension: a meta-analysis , 2012, The Lancet.

[12]  Shane J. Neph,et al.  Systematic Localization of Common Disease-Associated Variation in Regulatory DNA , 2012, Science.

[13]  Y. J. Kim,et al.  Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations , 2012, Nature Genetics.

[14]  Raymond K. Auerbach,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[15]  A. Morris,et al.  Transethnic Meta-Analysis of Genomewide Association Studies , 2011, Genetic epidemiology.

[16]  M. Nalls,et al.  Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function , 2011, PLoS genetics.

[17]  Neil Powe,et al.  Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD , 2011, PLoS genetics.

[18]  Thomas W. Mühleisen,et al.  Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease , 2011, Nature Genetics.

[19]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[20]  Eric Boerwinkle,et al.  Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry: A Prospective Meta-Analysis From the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium , 2010, Circulation. Cardiovascular genetics.

[21]  Mark N. Wass,et al.  Genetic loci influencing kidney function and chronic kidney disease , 2010, Nature Genetics.

[22]  Uwe Völker,et al.  New loci associated with kidney function and chronic kidney disease , 2010, Nature Genetics.

[23]  Thomas Meitinger,et al.  A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level , 2010, BMC Medical Genetics.

[24]  Christian Gieger,et al.  New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , 2010, Nature Genetics.

[25]  C. Meisinger,et al.  Effect of Chronic Kidney Disease and Comorbid Conditions on Health Care Costs: A 10-Year Observational Study in a General Population , 2009, American Journal of Nephrology.

[26]  M. Daly,et al.  Identifying Relationships among Genomic Disease Regions: Predicting Genes at Pathogenic SNP Associations and Rare Deletions , 2009, PLoS genetics.

[27]  Yurii S. Aulchenko,et al.  Multiple loci associated with indices of renal function and chronic kidney disease , 2009, Nature Genetics.

[28]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[29]  A. Boyles,et al.  National Institute of Environmental Health Sciences , 2008 .

[30]  C. Schmid,et al.  Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. , 2008, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[31]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[32]  G. Abecasis,et al.  Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies , 2006, Nature Genetics.

[33]  Daniel Levy,et al.  Predictors of new-onset kidney disease in a community-based population. , 2004, JAMA.

[34]  John D. Storey,et al.  Strong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach , 2004 .

[35]  John D. Storey.  A direct approach to false discovery rates , 2002 .

[36]  Tom Greene,et al.  Calibration and random variation of the serum creatinine assay as critical elements of using equations to estimate glomerular filtration rate. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[37]  W James Gauderman,et al.  Sample size requirements for matched case‐control studies of gene–environment interaction , 2002, Statistics in medicine.

[38]  D. Barker.  Fetal and infant origins of adult disease , 2001, Monatsschrift Kinderheilkunde.

[39]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[40]  Christine Imms.  is the Institutional Repository of The University of Melbourne , 2016 .

[41]  J. Himmelfarb,et al.  New therapies for diabetic kidney disease. , 2013, The New England journal of medicine.

[42]  J. Stockman.  Genetic Variants Associated With Cardiac Structure and Function: A Meta-analysis and Replication of Genome-wide Association Data , 2011 .

[43]  M. El Nahas,et al.  The global challenge of chronic kidney disease. , 2005, Kidney international.

[44]  Audrey Y. Chu,et al.  Genome-wide association and functional follow-up reveals new loci for kidney function , 2012 .