Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation.

[1]  P. Collas Epigenetic states in stem cells. , 2009, Biochimica et biophysica acta.

[2]  Albert Jeltsch,et al.  Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. , 2008, RNA.

[3]  R. Hines,et al.  Differential regulation of human hepatic flavin containing monooxygenase 3 (FMO3) by CCAAT/enhancer-binding protein beta (C/EBPbeta) liver inhibitory and liver activating proteins. , 2008, Biochemical pharmacology.

[4]  F. Lyko,et al.  Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine , 2008, International journal of cancer.

[5]  G. Cimino,et al.  Epigenetic plasticity of chromatin in embryonic and hematopoietic stem/progenitor cells: therapeutic potential of cell reprogramming , 2008, Leukemia.

[6]  Z. Gong,et al.  Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish. , 2008, Developmental biology.

[7]  T. Vanhaecke,et al.  Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes. , 2008, Toxicology letters.

[8]  S. Hiebert,et al.  Liver‐specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks , 2008, The EMBO journal.

[9]  David C Hay,et al.  Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development In Vivo , 2008, Stem cells.

[10]  Y. Ohde,et al.  5‐Aza‐2′‐deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up‐regulation of the connexin 32 gene , 2008, British Journal of Pharmacology.

[11]  Albert Jeltsch,et al.  Cyclical DNA methylation of a transcriptionally active promoter , 2008, Nature.

[12]  B. Christ,et al.  Hepatocytes derived from adult stem cells. , 2008, Transplantation proceedings.

[13]  H. Mizumoto,et al.  Hepatic differentiation of embryonic stem cells in HF/organoid culture. , 2008, Transplantation proceedings.

[14]  N. Langrana,et al.  Functional Modulation of ES-Derived Hepatocyte Lineage Cells via Substrate Compliance Alteration , 2008, Annals of Biomedical Engineering.

[15]  J. Mariadason HDACs and HDAC inhibitors in colon cancer , 2008, Epigenetics.

[16]  Catharine L. Smith A shifting paradigm: histone deacetylases and transcriptional activation , 2008, BioEssays : news and reviews in molecular, cellular and developmental biology.

[17]  T. Haarmann-Stemmann,et al.  Analysis of the Transcriptional Regulation and Molecular Function of the Aryl Hydrocarbon Receptor Repressor in Human Cell Lines , 2007, Drug Metabolism and Disposition.

[18]  T. Vanhaecke,et al.  Inhibition of NF‐κB activation by the histone deacetylase inhibitor 4‐Me2N‐BAVAH induces an early G1 cell cycle arrest in primary hepatocytes , 2007 .

[19]  Yi Zhang,et al.  New Nomenclature for Chromatin-Modifying Enzymes , 2007, Cell.

[20]  I. Hisatome,et al.  A role of Wnt/β-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells , 2007 .

[21]  J. Licht,et al.  Epigenetic regulation of normal and malignant hematopoiesis , 2007, Oncogene.

[22]  J. Westendorf,et al.  Gene profile analysis of osteoblast genes differentially regulated by histone deacetylase inhibitors , 2007, BMC Genomics.

[23]  T. Vanhaecke,et al.  Inhibition of NF‐κB activation by the histone deacetylase inhibitor 4‐Me2N‐BAVAH induces an early G1 cell cycle arrest in primary hepatocytes , 2007, Cell proliferation.

[24]  Hong Wang,et al.  Downregulation of connexin 43 in nasopharyngeal carcinoma cells is related to promoter methylation. , 2007, Oral oncology.

[25]  S. Kulp,et al.  Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma , 2007, Hepatology.

[26]  J. Hengstler,et al.  Fate of extrahepatic human stem and precursor cells after transplantation into mouse livers , 2007, Hepatology.

[27]  C. Allis,et al.  Chromatin remodeling and cancer, Part I: Covalent histone modifications. , 2007, Trends in molecular medicine.

[28]  C. Boyault,et al.  HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination , 2007, Oncogene.

[29]  E. Seto,et al.  HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention , 2007, Oncogene.

[30]  Maud Martin,et al.  Class IIa histone deacetylases: regulating the regulators , 2007, Oncogene.

[31]  P. Marks,et al.  Histone deacetylase inhibitors: molecular mechanisms of action , 2007, Oncogene.

[32]  Janghwan Kim,et al.  Characterization of DNA methylation change in stem cell marker genes during differentiation of human embryonic stem cells. , 2007, Biochemical and biophysical research communications.

[33]  B. Christ,et al.  Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo. , 2007, Experimental cell research.

[34]  S. Gery,et al.  Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells , 2007, International journal of cancer.

[35]  T. Ekström,et al.  HDAC inhibition amplifies gap junction communication in neural progenitors: potential for cell-mediated enzyme prodrug therapy. , 2007, Experimental cell research.

[36]  T. Vanhaecke,et al.  The novel histone deacetylase inhibitor 4-Me2N-BAVAH differentially affects cell junctions between primary hepatocytes. , 2007, Toxicology.

[37]  J. Lloreta,et al.  In vitro differentiation of HT‐29 M6 mucus‐secreting colon cancer cells involves a trychostatin A and p27KIP1‐inducible transcriptional program of gene expression , 2007, Journal of cellular physiology.

[38]  Y. Maitani,et al.  Non-viral delivery of the connexin 43 gene with histone deacetylase inhibitor to human nasopharyngeal tumor cells enhances gene expression and inhibits in vivo tumor growth. , 2007, International journal of oncology.

[39]  A. Farcomeni,et al.  Valproic Acid Induces Neuroendocrine Differentiation and UGT2B7 Up-Regulation in Human Prostate Carcinoma Cell Line , 2007, Drug Metabolism And Disposition.

[40]  Oxana V. Baranova,et al.  CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells , 2007, Neurobiology of Disease.

[41]  W. Reik Stability and flexibility of epigenetic gene regulation in mammalian development , 2007, Nature.

[42]  T. Vanhaecke,et al.  Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow , 2007, BMC Developmental Biology.

[43]  R. Vento,et al.  SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib , 2007, Apoptosis.

[44]  M. Moyer,et al.  Induction of differentiation of colon cancer cells by combined inhibition of kinases and histone deacetylase. , 2007, Anticancer research.

[45]  J. Tomlinson,et al.  Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5 , 2007, Proceedings of the National Academy of Sciences.

[46]  J. Schwartz,et al.  CCAAT/enhancer-binding protein (C/EBP) beta is acetylated at multiple lysines: acetylation of C/EBPbeta at lysine 39 modulates its ability to activate transcription. , 2007, The Journal of biological chemistry.

[47]  Monte Westerfield,et al.  Multiple upstream modules regulate zebrafish myf5 expression , 2007, BMC Developmental Biology.

[48]  K. Jung,et al.  Dynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells , 2006, Experimental & Molecular Medicine.

[49]  K. Leong,et al.  Hepatic differentiation potential of commercially available human mesenchymal stem cells. , 2006, Tissue engineering.

[50]  K. Kang,et al.  In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood , 2006, Journal of veterinary science.

[51]  C. Martinez-Jimenez,et al.  Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4α Requires Coactivators Peroxisomal Proliferator Activated Receptor-γ Coactivator 1α and Steroid Receptor Coactivator 1 , 2006, Molecular Pharmacology.

[52]  T. Kondo Epigenetic alchemy for cell fate conversion. , 2006, Current opinion in genetics & development.

[53]  Jessica E. Bolden,et al.  Anticancer activities of histone deacetylase inhibitors , 2006, Nature Reviews Drug Discovery.

[54]  J. Rozga Liver support technology – an update , 2006, Xenotransplantation.

[55]  M. Capogrossi,et al.  Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. , 2006, Circulation research.

[56]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[57]  J. Hengstler,et al.  Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers , 2006, Gut.

[58]  M L Yarmush,et al.  Sodium butyrate‐treated embryonic stem cells yield hepatocyte‐like cells expressing a glycolytic phenotype , 2006, Biotechnology and bioengineering.

[59]  F. Tronche,et al.  Plasticity and expanding complexity of the hepatic transcription factor network during liver development. , 2006, Genes & development.

[60]  G. Batist,et al.  A histone deacetylation‐dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells , 2006, The Prostate.

[61]  Vera Rogiers,et al.  Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures. , 2006, Current drug metabolism.

[62]  Luke O Dannenberg,et al.  Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation , 2006, BMC Genomics.

[63]  Luke O Dannenberg,et al.  Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. , 2006, Alcoholism, clinical and experimental research.

[64]  T. Vanhaecke,et al.  Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[65]  Andrew J. Wilson,et al.  Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer* , 2006, Journal of Biological Chemistry.

[66]  Lü-sheng Si [Cancer epigenetics]. , 2006, Zhonghua bing li xue za zhi = Chinese journal of pathology.

[67]  N. Kobayashi,et al.  Differentiation of Human Embryonic Stem Cells to Hepatocytes Using Deleted Variant of HGF and Poly-amino-urethane-Coated Nonwoven Polytetrafluoroethylene Fabric , 2006, Cell transplantation.

[68]  M. Fraga,et al.  DNA methyltransferases control telomere length and telomere recombination in mammalian cells , 2006, Nature Cell Biology.

[69]  K. Moore,et al.  Stem Cells and Their Niches , 2006, Science.

[70]  G. Daley,et al.  Stem cells and their niche: a matter of fate , 2006, Cellular and Molecular Life Sciences CMLS.

[71]  Jimin Xu,et al.  Histone Deacetylase Inhibitor Depsipeptide Represses Nicotinamide N-Methyltransferase and Hepatocyte Nuclear Factor-1β Gene Expression in Human Papillary Thyroid Cancer Cells , 2006 .

[72]  E. Yu,et al.  DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. , 2006, Cancer letters.

[73]  H. Pearson Stem-cell tagging shows flaws , 2006, Nature.

[74]  R. Costa,et al.  C/EBPα and HNF6 protein complex formation stimulates HNF6‐dependent transcription by CBP coactivator recruitment in HepG2 cells , 2006, Hepatology.

[75]  A. Bird,et al.  Genomic DNA methylation: the mark and its mediators. , 2006, Trends in biochemical sciences.

[76]  N. Theise Gastrointestinal stem cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[77]  T. Vanhaecke,et al.  Histone Deacetylase Inhibition: A Differentiation Therapy for Cultured Primary Hepatocytes? , 2006 .

[78]  W. Zang,et al.  Fibroblast growth factor-4 and hepatocyte growth factor induce differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocytes. , 2005, World journal of gastroenterology.

[79]  H. Blum,et al.  Hepatocellular carcinoma: therapy and prevention. , 2005, World journal of gastroenterology.

[80]  N. Benvenisty,et al.  Study of hepatocyte differentiation using embryonic stem cells , 2005, Journal of cellular biochemistry.

[81]  S. Baylin,et al.  DNA methylation and gene silencing in cancer , 2005, Nature Clinical Practice Oncology.

[82]  V. Ambros,et al.  Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi , 2005, Nucleic acids research.

[83]  Stephan Sauer,et al.  The reorganisation of constitutive heterochromatin in differentiating muscle requires HDAC activity. , 2005, Experimental cell research.

[84]  N. Yorioka,et al.  Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus. , 2005, Cancer research.

[85]  D. Ryu,et al.  Tissue-specific and de novo promoter methylation of the mouse glucose transporter 2. , 2005, Biological & pharmaceutical bulletin.

[86]  Hyunjin Cho,et al.  Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors , 2005, Journal of cellular biochemistry.

[87]  T. Yao,et al.  Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death , 2005, The Journal of Neuroscience.

[88]  S. Seo,et al.  Histone deacetylase 1 contributes to cell cycle and apoptosis. , 2005, Biological & pharmaceutical bulletin.

[89]  J. Schwartz,et al.  Endogenous CCAAT/enhancer binding protein beta and p300 are both regulated by growth hormone to mediate transcriptional activation. , 2005, Molecular endocrinology.

[90]  Y. C. Lee,et al.  Sp1 elements in SULT2B1b promoter and 5′‐untranslated region of mRNA: Sp1/Sp2 induction and augmentation by histone deacetylase inhibition , 2005, FEBS letters.

[91]  E. Chavakis,et al.  Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells , 2005, The Journal of experimental medicine.

[92]  S. Wölfl,et al.  Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics. , 2005, Carcinogenesis.

[93]  F. Oesch,et al.  Generation of human hepatocytes by stem cell technology: definition of the hepatocyte , 2005, Expert opinion on drug metabolism & toxicology.

[94]  P. Casaccia‐Bonnefil,et al.  Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain , 2005, The Journal of cell biology.

[95]  S. Bilodeau,et al.  Rb Enhances p160/SRC Coactivator-dependent Activity of Nuclear Receptors and Hormone Responsiveness* , 2005, Journal of Biological Chemistry.

[96]  Dong Hoon Kim,et al.  Hepatic steatosis in transgenic mice overexpressing human histone deacetylase 1. , 2005, Biochemical and biophysical research communications.

[97]  Moshe Szyf,et al.  DNA Methylation and Demethylation as Targets for Anticancer Therapy , 2005, Biochemistry (Moscow).

[98]  L. Sung,et al.  Methylation and Acetylation Characteristics of Cloned Bovine Embryos from Donor Cells Treated with 5-aza-2′-Deoxycytidine1 , 2005, Biology of reproduction.

[99]  Xiang-Jiao Yang,et al.  Class II Histone Deacetylases: from Sequence to Function, Regulation, and Clinical Implication , 2005, Molecular and Cellular Biology.

[100]  Min-Jeong Seo,et al.  Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo. , 2005, Biochemical and biophysical research communications.

[101]  L. Altucci,et al.  Molecular pathways involved in neural in vitro differentiation of marrow stromal stem cells , 2005, Journal of cellular biochemistry.

[102]  S. Amin,et al.  Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells. , 2005, Bioorganic & medicinal chemistry letters.

[103]  A. Jauch,et al.  In vivo haematopoietic activity is induced in neurosphere cells by chromatin‐modifying agents , 2005, The EMBO journal.

[104]  B. Turner,et al.  Reading signals on the nucleosome with a new nomenclature for modified histones , 2005, Nature Structural &Molecular Biology.

[105]  M. Gregor,et al.  Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357. , 2005, Journal of hepatology.

[106]  T. Vanhaecke,et al.  Differential Effects of Histone Deacetylase Inhibitors in Tumor and Normal Cells—What Is the Toxicological Relevance? , 2005, Critical reviews in toxicology.

[107]  F. Gage,et al.  Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[108]  John M. Shelton,et al.  Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis , 2004, Cell.

[109]  T. Ekström,et al.  HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells. , 2004, Biochemical and biophysical research communications.

[110]  W. Richardson,et al.  A Dynamic Switch in the Replication Timing of Key Regulator Genes in Embryonic Stem Cells upon Neural Induction , 2004, Cell cycle.

[111]  Frank Lyko,et al.  DNA methyltransferase inhibitors: old and new drugs for an epigenetic cancer therapy. , 2004, Trends in pharmacological sciences.

[112]  P. Jones,et al.  Zebularine: a new drug for epigenetic therapy. , 2004, Biochemical Society transactions.

[113]  Y. Yen,et al.  Hypermethylation of growth arrest DNA damage-inducible gene 45 beta promoter in human hepatocellular carcinoma. , 2004, The American journal of pathology.

[114]  J. Westendorf,et al.  Histone Deacetylase 3 Interacts with Runx2 to Repress the Osteocalcin Promoter and Regulate Osteoblast Differentiation* , 2004, Journal of Biological Chemistry.

[115]  Y. Maehara,et al.  cDNA Microarray Analysis in Hepatocyte Differentiation in Huh 7 Cells , 2004, Cell transplantation.

[116]  M. Kamihira,et al.  Transcriptional coactivators CBP and p300 cooperatively enhance HNF-1alpha-mediated expression of the albumin gene in hepatocytes. , 2004, Journal of biochemistry.

[117]  D. Ryu,et al.  CpG methylation of the mouse CYP1A2 promoter. , 2004, Toxicology letters.

[118]  T. Vanhaecke,et al.  Effect of the histone deacetylase inhibitor trichostatin A on spontaneous apoptosis in various types of adult rat hepatocyte cultures. , 2004, Biochemical pharmacology.

[119]  M. Merville,et al.  Modulation of the HSV-TK/ganciclovir bystander effect by n-butyrate in glioblastoma: correlation with gap-junction intercellular communication. , 2004, International journal of oncology.

[120]  I. Suetake,et al.  DNMT3L Stimulates the DNA Methylation Activity of Dnmt3a and Dnmt3b through a Direct Interaction* , 2004, Journal of Biological Chemistry.

[121]  N. Mahmud,et al.  Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A. , 2004, Blood.

[122]  J. Castell,et al.  Role of hepatocyte nuclear factor 3γ in the expression of human CYP2C genes , 2004 .

[123]  J. Trosko,et al.  Epigenetics and cancer: implications for drug discovery and safety assessment. , 2004, Toxicology and applied pharmacology.

[124]  T. Ekström,et al.  Histone deacetylase inhibitor 4-phenylbutyrate modulates glial fibrillary acidic protein and connexin 43 expression, and enhances gap-junction communication, in human glioblastoma cells. , 2004, European journal of cancer.

[125]  M. Nachtigal,et al.  Inhibition of Histone Deacetylase Activity by Valproic Acid Blocks Adipogenesis* , 2004, Journal of Biological Chemistry.

[126]  Y. Sheen,et al.  Histone deacetylase inhibitor stimulateCYP3A4 proximal promoter activity in hepg2 cells , 2004, Archives of pharmacal research.

[127]  Anirvan Ghosh,et al.  FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation , 2004, Nature Neuroscience.

[128]  D. Skalnik,et al.  Histone deacetylase activity is required for embryonic stem cell differentiation , 2004, Genesis.

[129]  R. Costa,et al.  Transcription factors in liver development, differentiation, and regeneration , 2003, Hepatology.

[130]  J. Herman,et al.  Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. , 2003, Cancer research.

[131]  F. Bone,et al.  Regulation of Glucose-6-phosphatase Gene Expression in Cultured Hepatocytes and H4IIE Cells by Short-chain Fatty Acids , 2003, Journal of Biological Chemistry.

[132]  S. Pradhan,et al.  Mammalian DNA (cytosine-5) methyltransferases and their expression. , 2003, Clinical immunology.

[133]  Wilbert,et al.  Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate. , 2003, Carcinogenesis.

[134]  M. Nakajima,et al.  Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells. , 2003, Toxicology letters.

[135]  T. Vanhaecke,et al.  Trichostatin A induces differential cell cycle arrests but does not induce apoptosis in primary cultures of mitogen-stimulated rat hepatocytes. , 2003, Journal of hepatology.

[136]  Manel Esteller,et al.  Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. , 2003, Cancer research.

[137]  M. Makuuchi,et al.  Sera from liver failure patients and a demethylating agent stimulate transdifferentiation of murine bone marrow cells into hepatocytes in coculture with nonparenchymal liver cells. , 2003, Journal of hepatology.

[138]  G. Otterson,et al.  The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells. , 2003, Current medicinal chemistry. Anti-cancer agents.

[139]  M. Ingelman-Sundberg,et al.  Transcriptional Regulation of Human CYP3A4 Basal Expression by CCAAT Enhancer-Binding Protein α and Hepatocyte Nuclear Factor-3γ , 2003 .

[140]  K. Bair,et al.  Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase. , 2003, The Journal of organic chemistry.

[141]  H. Yamasaki,et al.  Down-Regulation of Connexin 32 Gene Expression through DNA Methylation in a Human Renal Cell Carcinoma Cell , 2003, American Journal of Nephrology.

[142]  M. Torres-Padilla,et al.  Effects of interactions of hepatocyte nuclear factor 4α isoforms with coactivators and corepressors are promoter‐specific , 2003, FEBS letters.

[143]  K. Sugimachi,et al.  Histone deacetylase inhibitor trichostatin a induces cell‐cycle arrest/apoptosis and hepatocyte differentiation in human hepatoma cells , 2003, International journal of cancer.

[144]  F. Gonzalez,et al.  Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. , 2003, Biochimica et biophysica acta.

[145]  H. Yamasaki,et al.  The expression of the tumor suppressor gene connexin 26 is not mediated by methylation in human esophageal cancer cells , 2003, Molecular carcinogenesis.

[146]  M. Grever,et al.  Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells , 2003, Leukemia.

[147]  Pratima Kundu,et al.  Generation of Hepatocyte-Like Cells from Human Embryonic Stem Cells , 2003, Cell transplantation.

[148]  R. Costa,et al.  Association between Hepatocyte Nuclear Factor 6 (HNF-6) and FoxA2 DNA Binding Domains Stimulates FoxA2 Transcriptional Activity but Inhibits HNF-6 DNA Binding , 2003, Molecular and Cellular Biology.

[149]  M. Muggironi,et al.  Histone Deacetylase Activity Is Necessary for Oligodendrocyte Lineage Progression , 2002, The Journal of Neuroscience.

[150]  F. Sladek,et al.  Developmentally Regulated N-terminal Variants of the Nuclear Receptor Hepatocyte Nuclear Factor 4α Mediate Multiple Interactions through Coactivator and Corepressor-Histone Deacetylase Complexes* , 2002, The Journal of Biological Chemistry.

[151]  E. Olson,et al.  Association of Class II Histone Deacetylases with Heterochromatin Protein 1: Potential Role for Histone Methylation in Control of Muscle Differentiation , 2002, Molecular and Cellular Biology.

[152]  R. Johnstone The evolution of inaccurate mimics , 2002, Nature.

[153]  N. Wright,et al.  Gastrointestinal stem cells , 2002, The Journal of pathology.

[154]  W. Nelson,et al.  Methyl-CpG Binding Domain Protein 2 Represses Transcription from Hypermethylated π-Class Glutathione S-Transferase Gene Promoters in Hepatocellular Carcinoma Cells* , 2002, The Journal of Biological Chemistry.

[155]  S. Toyokuni,et al.  Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. , 2002, Diabetes.

[156]  B. Hinnebusch,et al.  The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. , 2002, The Journal of nutrition.

[157]  Toru Kita,et al.  Differentiation of embryonic stem cells into cardiac myocytes , 2002 .

[158]  F. Sladek,et al.  Competitive Cofactor Recruitment by Orphan Receptor Hepatocyte Nuclear Factor 4α1: Modulation by the F Domain , 2002, Molecular and Cellular Biology.

[159]  H. Schrem,et al.  Liver-Enriched Transcription Factors in Liver Function and Development. Part I: The Hepatocyte Nuclear Factor Network and Liver-Specific Gene Expression , 2002, Pharmacological Reviews.

[160]  Shawn D Seidel,et al.  Repression of hepatocyte nuclear factor 4alpha tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity. , 2002, Molecular endocrinology.

[161]  Alexander Dobrovic,et al.  Variable promoter region CpG island methylation of the putative tumor suppressor gene Connexin 26 in breast cancer. , 2002, Carcinogenesis.

[162]  Frank R. Lin,et al.  Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. , 2002, Molecular cell.

[163]  D. Schuppan,et al.  The histone-deacetylase inhibitor Trichostatin A blocks proliferation and triggers apoptotic programs in hepatoma cells. , 2002, Journal of hepatology.

[164]  Gangning Liang,et al.  Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements , 2002, Molecular and Cellular Biology.

[165]  R. Edwards,et al.  Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells , 2002, Xenobiotica; the fate of foreign compounds in biological systems.

[166]  S. Piantadosi,et al.  Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide. , 2001, Cancer research.

[167]  N. Rosen,et al.  The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells. , 2001, Cancer research.

[168]  T. Hayamizu,et al.  Transcription Factor FoxA (HNF3) on a Nucleosome at an Enhancer Complex in Liver Chromatin* , 2001, The Journal of Biological Chemistry.

[169]  L. Kedes,et al.  Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis. , 2001, Molecular cell.

[170]  M. Jung,et al.  Inhibitors of histone deacetylase as new anticancer agents. , 2001, Current medicinal chemistry.

[171]  Z. Kmieć,et al.  Cooperation of Liver Cells in Health and Disease , 2001, Advances in Anatomy Embryology and Cell Biology.

[172]  F. Kadlubar,et al.  Specific site methylation in the 5'-flanking region of CYP1A2 interindividual differences in human livers. , 2001, Life sciences.

[173]  E. Falvey,et al.  The activation function-1 of hepatocyte nuclear factor-4 is an acidic activator that mediates interactions through bulky hydrophobic residues. , 2001, The Biochemical journal.

[174]  O. MacDougald,et al.  p300 Coactivates the Adipogenic Transcription Factor CCAAT/Enhancer-binding Protein α* , 2001, The Journal of Biological Chemistry.

[175]  D. Kaufman,et al.  Multilineage Differentiation from Human Embryonic Stem Cell Lines , 2001, Stem cells.

[176]  C. Plass,et al.  Methylation matters , 2001, Journal of medical genetics.

[177]  B. Viollet,et al.  Transcription factor‐dependent regulation of CBP and P/CAF histone acetyltransferase activity , 2001, The EMBO journal.

[178]  T. Ekström,et al.  The human histone deacetylase family. , 2001, Experimental cell research.

[179]  G. Blobel,et al.  Stimulation of CREB Binding Protein Nucleosomal Histone Acetyltransferase Activity by a Class of Transcriptional Activators , 2001, Molecular and Cellular Biology.

[180]  T. Bestor,et al.  The DNA methyltransferases of mammals. , 2000, Human molecular genetics.

[181]  E. Seidman,et al.  Inhibition by deacetylase inhibitors of IL-1-dependent induction of haptoglobin involves CCAAT/Enhancer-binding protein isoforms in intestinal epithelial cells. , 2000, Biochemical and biophysical research communications.

[182]  U. Weidle,et al.  Inhibition of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment. , 2000, Anticancer research.

[183]  I. Talianidis,et al.  Transcriptional Activation by Hepatocyte Nuclear Factor-1 Requires Synergism between Multiple Coactivator Proteins* , 2000, The Journal of Biological Chemistry.

[184]  A. Wolffe,et al.  Review: chromatin structural features and targets that regulate transcription. , 2000, Journal of structural biology.

[185]  J. Bertram,et al.  Correlation between growth control, neoplastic potential and endogenous connexin43 expression in HeLa cell lines: implications for tumor progression. , 2000, Carcinogenesis.

[186]  Guillaume Adelmant,et al.  Activation of PPARγ coactivator-1 through transcription factor docking , 1999 .

[187]  F. Sladek,et al.  Modulation of Transcriptional Activation and Coactivator Interaction by a Splicing Variation in the F Domain of Nuclear Receptor Hepatocyte Nuclear Factor 4α1 , 1999, Molecular and Cellular Biology.

[188]  P. Marks,et al.  Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors , 1999, Nature.

[189]  S. Schreiber,et al.  Three proteins define a class of human histone deacetylases related to yeast Hda1p. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[190]  M. Hadzopoulou-Cladaras,et al.  CREB-binding Protein Is a Transcriptional Coactivator for Hepatocyte Nuclear Factor-4 and Enhances Apolipoprotein Gene Expression* , 1999, The Journal of Biological Chemistry.

[191]  R. Burk,et al.  Regulation of connexin32 and connexin43 gene expression by DNA methylation in rat liver cells. , 1999, Carcinogenesis.

[192]  D. Granner,et al.  SRC-1 and GRIP1 Coactivate Transcription with Hepatocyte Nuclear Factor 4* , 1998, The Journal of Biological Chemistry.

[193]  E. Kokkotou,et al.  Critical Structural Elements and Multitarget Protein Interactions of the Transcriptional Activator AF-1 of Hepatocyte Nuclear Factor 4* , 1998, The Journal of Biological Chemistry.

[194]  A. Fukamizu,et al.  Functional association between CBP and HNF4 in trans-activation. , 1997, Biochemical and biophysical research communications.

[195]  K. Klempnauer,et al.  Interaction and functional collaboration of p300 and C/EBPbeta , 1997, Molecular and cellular biology.

[196]  M. Grunstein Histone acetylation in chromatin structure and transcription , 1997, Nature.

[197]  M. Negishi,et al.  Transcriptional regulation by HNF-4 of the steroid 15α-hydroxylase P450 (Cyp2a-4) gene in mouse liver , 1997, Journal of Steroid Biochemistry and Molecular Biology.

[198]  Y. Oshika,et al.  P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo. , 1996, British Journal of Cancer.

[199]  Y. Chen,et al.  Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. , 1996, Genes & development.

[200]  T. Cresteil,et al.  Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period. , 1996, European journal of biochemistry.

[201]  R. Kobayashi,et al.  A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP , 1995, Molecular and cellular biology.

[202]  V. Rogiers,et al.  Effects of the anticonvulsant, valproate, on the expression of components of the cytochrome-P-450-mediated monooxygenase system and glutathione S-transferases. , 1995, European journal of biochemistry.

[203]  X. Wang,et al.  Alteration of transcription factor mRNAs during the isolation and culture of rat hepatocytes suggests the activation of a proliferative mode underlies their de-differentiation. , 1993, Biochemical and biophysical research communications.

[204]  K. Zaret,et al.  Hepatocyte differentiation initiates during endodermal-mesenchymal interactions prior to liver formation. , 1991, Development.

[205]  F. Gonzalez,et al.  Specific cytosine demethylations within the first exons of the rat CYP2D3 and CYP2D5 genes are associated with activation of hepatic gene expression during development. , 1990, DNA and cell biology.

[206]  F. Tronche,et al.  The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation , 1989, Molecular and cellular biology.

[207]  C. Petropoulos,et al.  Methylation of the alphafetoprotein gene in cell populations isolated from rat livers during carcinogenesis. , 1985, Nucleic acids research.

[208]  N. Shiojiri Enzymo- and immunocytochemical analyses of the differentiation of liver cells in the prenatal mouse. , 1981, Journal of embryology and experimental morphology.

[209]  Jian Xu,et al.  Pioneer factors, genetic competence, and inductive signaling: programming liver and pancreas progenitors from the endoderm. , 2008, Cold Spring Harbor symposia on quantitative biology.

[210]  I. Hisatome,et al.  A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[211]  T. Vanhaecke,et al.  Trichostatin A, a critical factor in maintaining the functional differentiation of primary cultured rat hepatocytes. , 2007, Toxicology and applied pharmacology.

[212]  U. Akavia,et al.  Differentiation of bone marrow stroma-derived mesenchymal cells. , 2007, Current medicinal chemistry.

[213]  Li-Xin Xiang,et al.  In vitro differentiation of hepatic progenitor cells from mouse embryonic stem cells induced by sodium butyrate , 2007, Journal of cellular biochemistry.

[214]  Stuart P. Atkinson,et al.  Epigenetics in embryonic stem cells: regulation of pluripotency and differentiation , 2007, Cell and Tissue Research.

[215]  T. Vanhaecke,et al.  Chromatin remodelling , a novel strategy to expedite the hepatic differentiation of adult bone marrow stem cells in vitro , 2006 .

[216]  T. Vanhaecke,et al.  Hepatocyte cultures in drug metabolism and toxicological research and testing. , 2006, Methods in molecular biology.

[217]  S. Kim,et al.  Epigenetic silencing of the sulfotransferase 1A1 gene by hypermethylation in breast tissue. , 2006, Oncology reports.

[218]  Jimin Xu,et al.  Histone deacetylase inhibitor depsipeptide represses nicotinamide N-methyltransferase and hepatocyte nuclear factor-1beta gene expression in human papillary thyroid cancer cells. , 2006, Thyroid.

[219]  C. Martinez-Jimenez,et al.  Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1. , 2006, Molecular Pharmacology.

[220]  S. Minucci,et al.  Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer , 2006, Nature Reviews Cancer.

[221]  M. Pacyna‐Gengelbach,et al.  Downregulation of connexin 26 in human lung cancer is related to promoter methylation , 2005, International journal of cancer.

[222]  P. Jagodziński,et al.  The role of mammalian DNA methyltransferases in the regulation of gene expression. , 2005, Cellular & molecular biology letters.

[223]  A. Trounson,et al.  Human embryonic stem cells and their spontaneous differentiation. , 2005, Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia.

[224]  P. Laird Cancer epigenetics. , 2005, Human molecular genetics.

[225]  C. Rödel,et al.  What is the role of radiotherapy in bladder-preserving cancer therapy? , 2005, Nature Clinical Practice Oncology.

[226]  T. Hibi,et al.  Gene expression associated with the decrease in malignant phenotype of human liver cancer cells following stimulation with a histone deacetylase inhibitor. , 2005, International journal of oncology.

[227]  D. Ryu,et al.  Regulation of CYP1A2 by histone deacetylase inhibitors in mouse hepatocytes , 2004, Journal of biochemical and molecular toxicology.

[228]  J. Castell,et al.  Role of hepatocyte nuclear factor 3 gamma in the expression of human CYP2C genes. , 2004, Archives of biochemistry and biophysics.

[229]  M. Ingelman-Sundberg,et al.  Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. , 2003, Molecular pharmacology.

[230]  J. Brody,et al.  Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP‐mediated transcription * , 2001, Journal of cellular biochemistry.

[231]  R. Singal,et al.  Modulation of the connexin26 tumor suppressor gene expression through methylation in human mammary epithelial cell lines. , 2000, Anticancer research.

[232]  P. Puigserver,et al.  Activation of PPARgamma coactivator-1 through transcription factor docking. , 1999, Science.

[233]  C. Woodcock,et al.  Nucleosome positioning by the winged helix transcription factor HNF3. , 1998, Genes & development.