High Serum IGFBP‐2 Is Predictive of Increased Bone Turnover in Aging Men and Women

Elevated serum IGFBP‐2 is associated with lower BMD in men and women. It is unknown whether IGFBP‐2 serves as a negative regulator of bone metabolism by decreasing bone formation or increasing bone resorption. Studying an age‐stratified community‐based sample of 344 men and 276 women, IGFBP‐2 was the strongest predictor of increased bone resorption among the IGF/IGFBPs studied.

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