Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium.

OVERVIEW 649 FEATURES OF CHEMOTACTIC BEHAVIOR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 650 HOW DO CELLS ACCOMPLISH CHEMOTAXIS? 652 Critical Questions . 652 Hypothetical Schemes for Chemotaxis 652 RESPONSES INDUCED BY ADDITION OF CHEMOATTRACTANTS . . . . . . . . . . . . . . . . . . . ....... . . . . . . . 656 Physiological Responses 656 Underlying Biochemistry .659 CHEMOATTRACTANT-INDUCED DESENSITIZATION ......... 669 Receptor Alterations 669 Additional Desensitization Mechanisms 670 CURRENT VIEW OF EUKARYOTIC CHEMOTAXIS . . . . . . . . . . ......... . . . . . . . . . .. ...... . ........ . . . . . . ...... . . . . . . . . 672 Biochemical Events Essential for Chemotaxis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 672 Working Modelfor Chemotaxis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 672

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