Phospholipase Activity Is Enhanced in Liver Microsomes from Chronic Alcoholic Rats a

Chronic ethanol intake is known to give rise to a resistance in cell membranes to the disordering effect of the lipids, in-vitro addition of other hydrophobic agents as well as by ethanol itself (for reviews see REFS. 1, 2). Also alterations in the fatty acid profiles of the phospholipids have been demonstrated to occur. We have therefore initiated studies on the enzymes involved in the re-tailoring of the membrane phospholipid fatty acid profiles and here report on studies on phospholipase activities in rat liver microsomes.