Scholte wave generation during single tracking location shear wave elasticity imaging of engineered tissues.

The physical environment of engineered tissues can influence cellular functions that are important for tissue regeneration. Thus, there is a critical need for noninvasive technologies capable of monitoring mechanical properties of engineered tissues during fabrication and development. This work investigates the feasibility of using single tracking location shear wave elasticity imaging (STL-SWEI) for quantifying the shear moduli of tissue-mimicking phantoms and engineered tissues in tissue engineering environments. Scholte surface waves were observed when STL-SWEI was performed through a fluid standoff, and confounded shear moduli estimates leading to an underestimation of moduli in regions near the fluid-tissue interface.

[1]  D. Rubens,et al.  Imaging the elastic properties of tissue: the 20 year perspective , 2011, Physics in medicine and biology.

[2]  Mark A Anastasio,et al.  Imaging challenges in biomaterials and tissue engineering. , 2013, Biomaterials.

[3]  P. C. Vinh.  Scholte-wave velocity formulae , 2013 .

[4]  Stephen A McAleavey,et al.  Single Tracking Location Methods Suppress Speckle Noise in Shear Wave Velocity Estimation , 2013, Ultrasonic imaging.

[5]  Diane Dalecki,et al.  Estimating Cell Concentration in Three-Dimensional Engineered Tissues Using High Frequency Quantitative Ultrasound , 2014, Annals of Biomedical Engineering.

[6]  Edward D Light,et al.  New Fabrication Techniques for Ring-Array Transducers for Real-Time 3D Intravascular Ultrasound , 2009, Ultrasonic imaging.

[7]  A. Khademhosseini,et al.  BIOMIMETIC GRADIENT HYDROGELS FOR TISSUE ENGINEERING. , 2010, The Canadian journal of chemical engineering.

[8]  Stephen McAleavey,et al.  Validation of SMURF Estimation of Shear Modulus in Hydrogels , 2009, Ultrasonic imaging.

[9]  Diane Dalecki,et al.  Ultrasound Technologies for Biomaterials Fabrication and Imaging , 2014, Annals of Biomedical Engineering.

[10]  F. Schubert,et al.  Leaky Rayleigh and Scholte waves at the fluid-solid interface subjected to transient point loading , 2004 .

[11]  J. R. Doherty,et al.  Acoustic radiation force elasticity imaging in diagnostic ultrasound , 2013, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[12]  M. Helguera,et al.  Noninvasive Quantitative Imaging of Collagen Microstructure in Three-Dimensional Hydrogels Using High-Frequency Ultrasound. , 2015, Tissue engineering. Part C, Methods.

[13]  S. Emelianov,et al.  Shear wave elasticity imaging: a new ultrasonic technology of medical diagnostics. , 1998, Ultrasound in medicine & biology.

[14]  J. Greenleaf,et al.  Selected methods for imaging elastic properties of biological tissues. , 2003, Annual review of biomedical engineering.