Full skin quantitative optical coherence elastography achieved by combining vibration and surface acoustic wave methods

By combining with the phase sensitive optical coherence tomography (PhS-OCT), vibration and surface acoustic wave (SAW) methods have been reported to provide elastography of skin tissue respectively. However, neither of these two methods can provide the elastography in full skin depth in current systems. This paper presents a feasibility study on an optical coherence elastography method which combines both vibration and SAW in order to give the quantitative mechanical properties of skin tissue with full depth range, including epidermis, dermis and subcutaneous fat. Experiments are carried out on layered tissue mimicking phantoms and in vivo human forearm and palm skin. A ring actuator generates vibration while a line actuator were used to excited SAWs. A PhS-OCT system is employed to provide the ultrahigh sensitive measurement of the generated waves. The experimental results demonstrate that by the combination of vibration and SAW method the full skin bulk mechanical properties can be quantitatively measured and further the elastography can be obtained with a sensing depth from ~0mm to ~4mm. This method is promising to apply in clinics where the quantitative elasticity of localized skin diseases is needed to aid the diagnosis and treatment.

[1]  Ruikang K. Wang,et al.  OCT-based elastography for large and small deformations. , 2006, Optics express.

[2]  R. Stephenson.  A and V , 1962, The British journal of ophthalmology.

[3]  N Iftimia,et al.  OCT-based arterial elastography: robust estimation exploiting tissue biomechanics. , 2004, Optics express.

[4]  J. Schmitt,et al.  OCT elastography: imaging microscopic deformation and strain of tissue. , 1998, Optics express.

[5]  Ruikang K. Wang,et al.  Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue , 2006 .

[6]  D. Sampson,et al.  In vivo dynamic optical coherence elastography using a ring actuator. , 2009, Optics express.

[7]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[8]  M. Tilleman,et al.  The elastic properties of cancerous skin: Poisson's ratio and Young's modulus. , 2004, The Israel Medical Association journal : IMAJ.

[9]  Victor X D Yang,et al.  Optical coherence elastography: current status and future applications. , 2011, Journal of biomedical optics.

[10]  J.F. Greenleaf,et al.  Skin viscoelasticity with surface wave method , 2008, 2008 IEEE Ultrasonics Symposium.

[11]  R O Potts,et al.  The dynamic mechanical properties of human skin in vivo. , 1983, Journal of biomechanics.

[12]  Jinying Zhu,et al.  Non-Contact NDT of Concrete Structures Using Air -Coupled Sensors , 2006 .

[13]  T. Krouskop,et al.  Elastic Moduli of Breast and Prostate Tissues under Compression , 1998, Ultrasonic imaging.

[14]  Simon Fleming,et al.  Laser ultrasonic surface wave dispersion technique for non-destructive evaluation of human dental enamel. , 2009, Optics express.

[15]  P Ciarletta,et al.  The radial growth phase of malignant melanoma: multi-phase modelling, numerical simulations and linear stability analysis , 2011, Journal of The Royal Society Interface.

[16]  Ruikang K. Wang,et al.  Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography , 2012, Journal of The Royal Society Interface.

[17]  Ruikang K. Wang,et al.  Elastic properties of soft tissue-mimicking phantoms assessed by combined use of laser ultrasonics and low coherence interferometry. , 2011, Optics express.

[18]  D. Schneider,et al.  A photoacoustic method for characterising thin films , 1997 .

[19]  Ruikang K. Wang,et al.  Phase-sensitive optical coherence elastography for mapping tissue microstrains in real time , 2007 .

[20]  J. Fujimoto,et al.  Optical coherence tomographic elastography technique for measuring deformation and strain of atherosclerotic tissues , 2004, Heart.

[21]  Ruikang K. Wang,et al.  Directional blood flow imaging in volumetric optical microangiography achieved by digital frequency modulation. , 2008, Optics letters.

[22]  Ruikang K. Wang,et al.  Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography. , 2010, Optics letters.

[23]  Xing Liang,et al.  Biomechanical Properties of In Vivo Human Skin From Dynamic Optical Coherence Elastography , 2010, IEEE Transactions on Biomedical Engineering.

[24]  S. Boppart,et al.  Optical micro-scale mapping of dynamic biomechanical tissue properties. , 2008, Optics express.

[25]  Derek K. Gerstmann,et al.  In vivo three-dimensional optical coherence elastography◊ , 2011, Optics express.

[26]  M. Fink,et al.  Assessment of elastic parameters of human skin using dynamic elastography , 2004, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[27]  Ruikang K. Wang,et al.  Quantitative elastography provided by surface acoustic waves measured by phase-sensitive optical coherence tomography. , 2012, Optics letters.

[28]  S. Boppart,et al.  Optical coherence elastography of engineered and developing tissue. , 2006, Tissue engineering.

[29]  John Lambros,et al.  Digital Image Correlation for Improved Detection of Basal Cell Carcinoma , 2008 .

[30]  Michiko Nakajima,et al.  Clinical Application of Real-time Tissue Elastography on Skin Lesions , 2007 .

[31]  Ruikang K. Wang,et al.  Depth profiling of photothermal compound concentrations using phase sensitive optical coherence tomography. , 2011, Journal of biomedical optics.

[32]  Peter Hess,et al.  Laser generation and detection of surface acoustic waves: Elastic properties of surface layers , 1992 .